Indications
Motegrity (active ingredient: prucalopride) is a prescription medication indicated for:
- Chronic Idiopathic Constipation (CIC): Motegrity is used to treat chronic idiopathic constipation in adults by enhancing bowel movements and alleviating associated symptoms.
Motegrity belongs to a class of drugs known as serotonin-4 (5-HT4) receptor agonists, which work by stimulating the muscles in the gastrointestinal tract to promote bowel motility and improve bowel function.
Uses and Dosage
Motegrity is available in tablet form and should be taken orally with or without food, as directed by a doctor. Typically, the medication should be taken once a day, and the dosage will depend on several factors such as age, medical condition, and response to treatment. The recommended dosage is usually around 2 milligrams per day. For optimal results, it is important to take Motegrity regularly and at the same time each day.
The recommended dosage for Motegrity is typically 2 milligrams per day for the treatment of chronic idiopathic constipation (CIC) in adults. The typical dose is 2 mg by mouth once daily. If you have severe kidney problems, your dose may be adjusted to 1 mg by mouth once daily. However, the dosage may be adjusted based on factors such as age, medical condition, and response to treatment.
Side Effect
Common Side Effects of Motegrity (Prucalopride Succinate):
- Diarrhea
- Dizziness
- Fatigue
- Gas
- Headache
- Nausea
- Stomach area (abdominal) pain or bloating
- Vomiting
Serious Side Effects of Motegrity (Prucalopride Succinate):
- Unusual changes in mood or behavior
- Thoughts of hurting yourself
- Trying to hurt yourself
- You feel sad
- Hopeless or begin to have thoughts of suicide
Form and Strength
Motegrity (Prucalopride Succinate) is available in the following forms and strengths:
Motegrity: Film-Coated Tablet
- 1 mg
- 2 mg
Prucalopride Succinate: Film-Coated Tablet
- 2 mg
Caution
- Inform your healthcare provider (HCP) about any medical conditions, especially if you have or have had depression, suicidal thoughts or actions, or mood problems, before taking Motegrity or any other medication.
- If you have kidney problems, it may be necessary for your healthcare provider to adjust the dosage of Motegrity and prescribe a lower dose. Inform your HCP about any such medical conditions before taking Motegrity or any other medication.
- To ensure your safety, do not take Motegrity if you have a tear in your stomach or intestinal wall (bowel perforation), a bowel blockage (intestinal obstruction), or if you have serious conditions affecting the intestinal wall, such as Crohn's disease or ulcerative colitis.
- Inform your healthcare provider if you are pregnant or planning to become pregnant before taking Motegrity. If this medication can harm an unborn baby, your HCP may need to adjust your dosage or recommend an alternative treatment.
- To ensure your safety, do not take Motegrity if you have an allergy to it. Allergic reactions can cause symptoms such as difficulty breathing, skin rash, itching, and swelling of the face, lips, tongue, or throat. If you experience any of these symptoms, seek medical attention immediately.
- During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.
- Motegrity may cause dizziness as a side effect. Avoid driving, using machinery, or engaging in activities that require alertness until you can safely do so. Drinking alcohol or using marijuana (cannabis) can increase the risk of dizziness, so limit alcohol consumption and talk to your healthcare provider if you are using marijuana.
Frequently Asked Questions (FAQ)
How long does it take for Motegrity (prucalopride) to work?
Motegrity (prucalopride) does not work very quickly the way some laxatives do, so it should be taken regularly, not as needed. The typical time to first bowel movement after dosing of Motegrity (prucalopride) on day 1 ranged from 1 to 5 days.
Is Motegrity (prucalopride) safe to take while pregnant?
There is not enough information to determine whether taking Motegrity (prucalopride) is safe during pregnancy. There is a registry that monitors pregnancy outcomes in women exposed to Motegrity (prucalopride) during pregnancy.
How should I take Motegrity?
Motegrity should be taken orally with or without food, as directed by a doctor. The recommended dosage is typically 2 milligrams per day, but this may vary based on factors such as age, medical condition, and response to treatment.
What should I do if I miss a dose?
If you miss a dose of Motegrity, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Can I take Motegrity if I am pregnant or breastfeeding?
If you are pregnant or breastfeeding, the effects on a developing fetus or infant are not yet known. Talk to your doctor if you are pregnant, planning to become pregnant, or breastfeeding before taking Motegrity.
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