Indications
Asacol HD (active ingredient: mesalamine) is a prescription medication indicated for:
- Treatment of Ulcerative Colitis: Asacol HD is indicated to treat mildly to moderately active ulcerative colitis (UC), an inflammatory bowel disease (IBD) that affects the colon and rectum. It is also prescribed for the maintenance of remission of ulcerative colitis.
Asacol HD belongs to the drug class known as aminosalicylates, which are thought to work by reducing inflammation in the colon.
Use and Dosage
Asacol HD comes in the form of delayed-release (enteric-coated) tablets that should be taken orally as directed by your healthcare provider, usually three times a day with or without food. Here are some important guidelines to follow:
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How to Take the Tablets:
- Swallow the tablets whole with a glass of water.
- Do not crush, break, or chew the tablets.
- For best results, take the tablet on an empty stomach, at least 1 hour before or 2 hours after a meal.
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Dosage:
- The typical dose is 1600 mg taken orally three times a day with or without food.
- Always follow your doctor's instructions regarding the dosage and administration of Asacol HD.
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Consult Your Healthcare Provider:
- Do not change your dosage or stop taking Asacol HD without first consulting your doctor.
- If you have any questions about how to use Asacol HD, talk to your doctor or pharmacist.
Side Effects
Common Side Effects of Asacol HD (Mesalamine):
- Nausea
- Vomiting
- Stomach pain
- Diarrhea
- Indigestion
- Gas
- Headache
- Rash
- Abnormal liver function tests
Serious Side Effects of Asacol HD (Mesalamine):
- Hives
- Difficulty breathing
- Swelling of your face lips tongue or throat
- Severe stomach pain
- Stomach cramping
- Bloody diarrhea
- Fever
- Headache
- Skin rash
- Bloody or tarry stools
- Coughing up blood
- Vomit that looks like coffee grounds
- Little or no urination
- Painful or difficult urination
- Swelling in your feet or ankles
- Tiredness
- Shortness of breath
- Loss of appetite
- Upper stomach pain
- Tiredness
- Easy bruising or bleeding
- Dark urine
- Clay-colored stools and
- Yellowing of the skin or eyes (jaundice)
Forms and Strength
Asacol HD (Mesalamine) is available in the following forms and strength:
Asacol HD: Delayed Release Tablet
- 800 mg
Mesalamine: Delayed Release Tablet (Enteric Coated)
- 800 mg
Warnings and Precautions
Important Safety Information for Asacol HD:
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Kidney Problems:
- Asacol HD may cause or worsen kidney issues.
- Your healthcare provider may check your kidney function before and during treatment.
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Blood Disorders:
- Asacol HD can affect blood cells, leading to decreased blood cell counts.
- Your blood may be monitored while you are taking this medication.
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Mesalamine-Induced Acute Intolerance Syndrome:
- Some people may experience worsening colitis symptoms or allergic reactions to mesalamine products like Asacol HD.
- If this occurs, stop taking the medication and inform your healthcare provider immediately.
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Drug Interactions:
- Asacol HD may interact with other medications, such as blood thinners or immunosuppressants, affecting their effectiveness.
- Inform your healthcare provider about all medications you are taking, including over-the-counter drugs and supplements.
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Liver Disease:
- Asacol HD may cause or worsen liver problems.
- Inform your healthcare provider if you have liver disease or a history of liver problems.
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Allergic Reactions:
- Some individuals may have allergic reactions to Asacol HD, including hives, difficulty breathing, or swelling of the face, lips, tongue, or throat.
- Seek emergency medical attention if you experience these symptoms.
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Pregnancy and Breastfeeding:
- Use Asacol HD during pregnancy or breastfeeding only if clearly needed.
- Discuss the risks and benefits with your healthcare provider.
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Impaired Renal Function:
- Asacol HD can cause renal impairment in patients with pre-existing kidney dysfunction.
- Close monitoring of renal function is recommended for these patients.
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Rare Gastrointestinal Side Effects:
- Rare cases of ischemic colitis and exacerbation of Crohn's disease have been reported.
- Inform your healthcare provider if you have a history of Crohn's disease or experience severe abdominal pain, bloody diarrhea, or fever while taking Asacol HD.
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Frequently Asked Questions (FAQ)
Can Asacol HD be used to treat Crohn's disease?
Asacol HD is not typically used to treat Crohn's disease because it primarily works in the colon. However, in some cases, it may be prescribed for patients with Crohn's disease who have inflammation in the colon.
Can Asacol HD be taken with other medications?
Asacol HD can interact with other medications. You should talk to your doctor about any other medications you are taking before starting Asacol HD.
How long does it take for Asacol HD to start working?
Asacol HD may take several weeks to start working. Continue taking the medication as prescribed, even if you do not notice improvement right away.
Can Asacol HD be taken with food?
Yes, Asacol HD should be taken with food to help improve absorption and reduce the risk of stomach upset.
How should Asacol HD be stored?
Asacol HD should be stored at room temperature and protected from moisture and light.
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