Monovisc (Sodium Hyaluronate) Shopper Approved

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Prescription Prescription Required FormationFormulation:

Sodium Hyaluronate

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Monovisc is a prescription medicine used to treat the symptoms of osteoarthritis of the knee. It contains sodium hyaluronate, which is a natural substance found in the body that helps lubricate and cushion joints.

Monovisc is made up of highly purified, partially cross-linked sodium hyaluronate in a phosphate-buffered saline solution. By supplementing the joint's natural hyaluronic acid, Monovisc aims to provide long-lasting relief of knee pain due to OA.

Uses and Dosage

The administration method and dosage of Monovisc may vary depending on the patient's individual needs and medical history.

Monovisc is typically administered as a single injection directly into the affected knee joint by a healthcare provider. The injection should strictly follow sterile technique and the dosage and frequency of administration should be determined by the healthcare provider according to the patient's individual needs. The patients receiving Monovisc injections should avoid strenuous activities and sports or prolonged weight-bearing activities for at least 48 hours after the injection.

Monovisc is usually administered as a single injection directly into the knee joint. However, in some cases, a second injection may be given one week after the first injection to provide additional pain relief. Do not receive more than two injections of Monovisc within a six-month period. The exact frequency of injections can vary depending on the individual's response to the treatment and the severity of their knee osteoarthritis.

Side effect

Common Side Effects of Monovisc (Sodium Hyaluronate):

  • Chills
  • Dizziness
  • General feeling of being unwell
  • Headache
  • Hives
  • Injection site reactions
  • Itching
  • Joint pain
  • Muscle cramps
  • Nausea
  • Rash
  • Swelling of the legs and feet
  • Swelling

Serious Side Effects of Monovisc (Sodium Hyaluronate):

  • Bleeding
  • Difficulty breathing
  • Hives
  • Increased knee pain
  • Swelling of your face, tongue, or throat
  • Warmth, swelling, or redness around the knee

Form and strength

Monovisc (Sodium Hyaluronate) is available in the following forms and strength:

Monovisc: Injection

  • 22 mg /mL


  • Monovisc should not be used if you are allergic to hyaluronate preparations or if you have infections or skin disease around the area of injection.
  • Some patients may experience mild-to-moderate knee pain, warmth and/or swelling after an injection with Monovisc. These symptoms usually resolve within a few days, but patients should contact their doctor if their symptoms persist or become severe.
  • Monovisc should be used with caution in patients with known hypersensitivity to avian proteins, feathers, or egg products, as it is derived from avian sources.
  • Patients should avoid strenuous or weight-bearing activities for 48 hours after receiving the injection to minimize the risk of damage to the knee joint.
  • Patients who are pregnant or breastfeeding should consult with their healthcare provider before receiving Monovisc.
  • Do not concomitantly use disinfectants containing quaternary ammonium salts for skin preparation as hyaluronan can precipitate in their presence.

Frequently Asked Questions (FAQ)

How does Monovisc compare to other osteoarthritis knee pain treatments?

Monovisc may provide comparable pain relief to other intra-articular hyaluronic acid injections, such as Synvisc and Hyalgan.

How long does Monovisc provide pain relief?

Monovisc injections have been shown to provide pain relief for up to six months in some patients.

How long does it take for Monovisc to start working?

Monovisc injections usually start providing relief of osteoarthritis knee pain at two weeks after injection.


Additional information

Generic name:

Sodium Hyaluronate




20mg/mL, 22mg/mL

Quantities Available:



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Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Monovisc (Sodium Hyaluronate). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Monovisc (Sodium Hyaluronate).