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Prescription Required
Formulation: Tablet
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Leucovorin (active ingredient: calcium folinate) is a prescription medication that helps protect healthy cells from the harmful effects of certain medications and treats conditions caused by low folate levels. It is commonly used during cancer treatment and in situations where the body cannot use folic acid normally.
Leucovorin is prescribed for the following uses:
Leucovorin is most commonly used as a rescue medication after high-dose methotrexate therapy. Methotrexate is a chemotherapy medication used to treat certain cancers, including osteosarcoma, leukemia, and other malignancies. While methotrexate is effective at destroying cancer cells, it can also damage healthy cells, leading to serious side effects.
When given after methotrexate, leucovorin helps reduce the medication’s harmful effects on healthy tissues without significantly decreasing its ability to fight cancer. This treatment, known as methotrexate rescue, helps lower the risk of severe side effects such as bone marrow suppression, mouth sores, and damage to the digestive tract.
Leucovorin is also used to treat folinic acid deficiency, a condition in which the body does not have enough active folate to support normal cell function.
Folinic acid deficiency may occur:
By restoring active folate levels, leucovorin helps support normal blood cell production, tissue repair, and other important cellular functions.
Leucovorin belongs to a class of medications known as folic acid derivatives. Unlike folic acid, leucovorin is an active form of folate that does not require the same metabolic conversion before the body can use it.
Folate is an essential B vitamin needed for:
During high-dose methotrexate therapy, leucovorin supplies healthy cells with the folate they need to continue functioning normally. This helps protect normal tissues from the toxic effects of methotrexate while allowing the chemotherapy to continue targeting cancer cells.
By restoring active folate, leucovorin also helps correct folate deficiency caused by medications or conditions that impair normal folate metabolism, supporting healthy cell function throughout the body.
Leucovorin is available as an oral tablet that should be taken exactly as prescribed by your healthcare provider. It may be taken with or without food. Taking the medication at the same time each day can help you remember your dose and maintain consistent levels of the medication in your body.
Always follow your healthcare provider’s instructions carefully. Do not increase, decrease, or stop taking Leucovorin on your own, as doing so may reduce the medication’s effectiveness or increase the risk of side effects. If you have any questions about your treatment schedule, speak with your healthcare provider or pharmacist.
The appropriate dosage of Leucovorin depends on several factors, including:
Because dosing is individualized, your healthcare provider will determine the dose and treatment schedule that is most appropriate for your specific situation.
In general, oral doses greater than 25 mg are not recommended, as absorption of Leucovorin decreases at higher doses. If a larger dose is needed, your healthcare provider may recommend an alternative route of administration.
To help ensure the medication works as intended:
If you miss a dose, contact your healthcare provider or pharmacist for guidance. Do not take two doses at the same time to make up for a missed dose unless you have been specifically instructed to do so.
Regular follow-up appointments may be necessary during treatment, especially if Leucovorin is being used with chemotherapy or other medications. Your healthcare provider may monitor your response to treatment and adjust your dosage if needed to ensure the medication is working safely and effectively.
Leucovorin (Calcium Folinate) is available in the following forms and strengths:
Before taking Leucovorin, tell your healthcare provider about your complete medical history, any allergies you have, and all prescription medications, over-the-counter medicines, vitamins, and herbal supplements you are taking. This information helps your healthcare provider determine whether Leucovorin is appropriate for you and whether any special precautions are needed during treatment.
Do not take Leucovorin if you have had an allergic reaction to:
Tell your healthcare provider or pharmacist if you have a history of medication allergies or other severe allergic reactions. Seek immediate medical attention if you develop symptoms of an allergic reaction, such as a rash, itching, swelling of the face or throat, severe dizziness, or difficulty breathing.
Leucovorin is sometimes given together with fluorouracil (5-FU) to improve the effectiveness of cancer treatment. However, this combination can also increase the risk of serious side effects because Leucovorin enhances the effects of fluorouracil.
Older adults may be especially sensitive to this combination and have a higher risk of developing severe or life-threatening complications, including:
Contact your healthcare provider immediately if you experience severe diarrhea, persistent vomiting, fever, signs of dehydration, or symptoms of infection while receiving Leucovorin with fluorouracil.
Tell your healthcare provider if you have anemia caused by vitamin B12 deficiency, such as pernicious anemia, before taking Leucovorin.
Although Leucovorin can improve some blood test results associated with folate deficiency, it does not treat vitamin B12 deficiency and may mask the blood-related signs of the condition while allowing nerve damage to continue. Your healthcare provider may perform additional testing to ensure you receive the appropriate treatment.
If you are pregnant, planning to become pregnant, or think you may be pregnant, discuss the potential benefits and risks of Leucovorin with your healthcare provider before starting treatment.
Leucovorin is often used as part of chemotherapy treatment or to reduce the toxic effects of methotrexate. Your healthcare provider will carefully weigh the expected benefits against any potential risks to you and your developing baby before recommending treatment during pregnancy.
Leucovorin is used as a rescue medication following high-dose methotrexate therapy and is also the standard treatment for accidental methotrexate overdose.
For Leucovorin to be most effective, it must be administered as soon as possible after excessive exposure to methotrexate or other folic acid antagonists. Delaying treatment reduces Leucovorin’s ability to protect healthy cells from methotrexate toxicity, increasing the risk of serious complications such as bone marrow suppression, severe mouth sores, and damage to the digestive tract.
Always follow your healthcare provider’s instructions carefully regarding the timing and dosing of Leucovorin, especially when it is prescribed as part of methotrexate treatment.
Depending on why you are taking Leucovorin, your healthcare provider may monitor your blood cell counts, kidney function, liver function, and response to treatment throughout therapy. Attend all scheduled follow-up appointments so your healthcare provider can ensure the medication is working safely and effectively.
Leucovorin is available in both oral tablet and injectable forms. Depending on the condition being treated, it may be taken by mouth or administered by a healthcare professional as an intravenous (IV) or intramuscular (IM) injection. Your healthcare provider will determine the most appropriate form based on your medical condition and treatment plan.
Leucovorin can interact with certain medications, including some chemotherapy drugs and medications that affect folate metabolism. Before starting treatment, tell your healthcare provider about all prescription medications, over-the-counter medicines, vitamins, herbal products, and dietary supplements you are taking. This helps your healthcare provider identify potential drug interactions and ensure your treatment is as safe and effective as possible.
Store Leucovorin tablets at room temperature, away from excessive heat, moisture, and direct light. Keep the medication in its original container and out of the reach of children and pets. Do not use the medication after its expiration date, and dispose of any unused medication according to your pharmacist’s instructions.
If you are pregnant, planning to become pregnant, or think you may be pregnant, talk to your healthcare provider before taking Leucovorin. The decision to use Leucovorin during pregnancy depends on your medical condition and the reason it has been prescribed. Your healthcare provider will carefully weigh the potential benefits of treatment against any possible risks before recommending its use.
The frequency of Leucovorin treatment depends on the condition being treated and your individual treatment plan. For example, when used as methotrexate rescue, it is given according to a carefully timed schedule after methotrexate therapy. In other situations, such as treating folate deficiency, the dosing schedule may be different. Always follow your healthcare provider’s instructions and take Leucovorin exactly as prescribed.
| Generic name: | Calcium Folinate |
|---|---|
| Formulation: | Tablet |
| Strength(s): | 5mg |
| Quantities Available: | 24, 48 |
Our online Canadian Pharmacy is known for high standards of quality, safety, and efficiency when it comes to medications.
Our pharmacy offers lower prices on prescription drugs compared to traditional pharmacies.
When ordering Leucovorin (calcium folinate) from a Canadian pharmacy, you can typically purchase up to a 90-day supply at one time, which is common for prescription medications to ensure adequate management without frequent refills.
Here’s what you need to know:
Dosage and Quantity: Leucovorin is available in 5 mg tablets. The dosage and quantity required for a 90-day supply will depend on your prescribed regimen, which your healthcare provider will determine based on your medical condition and treatment plan.
For example, if you are prescribed to take 1 tablet once daily, for a 90-day supply, you would order 90 tablets (90 days x 1 tablet per day).
No, we don’t sell calcium folinate, but you can still enjoy low prices on Leucovorin, which contains calcium folinate as an active ingredient. To order Leucovorin from our website, you will need a valid prescription from your healthcare provider. We require this to dispense the medication safely and accurately. You can submit your prescription by mail, fax, or by uploading it through your online account during the ordering process.
Yes, we ship Leucovorin (calcium folinate) to both the United States and Puerto Rico.
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Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Leucovorin (Calcium Folinate). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Leucovorin (Calcium Folinate).
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