Indications
Leucovorin (active ingredient: calcium folinate) is a prescription medication indicated for the following:
- Methotrexate Rescue: Leucovorin is used as a rescue agent in high-dose methotrexate therapy to diminish the toxicity and counteract the effects of methotrexate in patients with osteosarcoma, leukemia, and other malignancies.
- Folinic Acid Deficiency: It is also indicated for the treatment of folinic acid deficiency, which may occur as a result of certain medications, such as methotrexate, or in conditions associated with impaired folate metabolism.
Leucovorin belongs to a class of drugs known as folic acid derivatives, which work by providing a source of folate, a B vitamin essential for DNA synthesis, cell growth, and repair, thereby supporting normal cell function and mitigating the adverse effects of certain chemotherapy drugs like methotrexate.
Uses and Dosage
Leucovorin comes in the form of a tablet and is typically taken by mouth as a tablet, with or without food, as directed by your doctor. Do not increase or decrease the dosage on your own, as this can lead to unwanted side effects or reduced effectiveness of the medication.
The specific dosage and usage instructions for Leucovorin tablets depend on the patient's individual needs and medical history, as well as the condition being treated. Follow the instructions of a qualified healthcare professional when using this medication. They will be able to provide detailed instructions on how to use it properly.
The dosage and frequency of the medication will depend on the condition being treated and the patient's response to treatment. Doses above 25 milligrams are not recommended. Use the Leucovorin tablet regularly to get the most benefit from it. To help you remember, take it at the same time each day.
Side Effects
Common Side Effects of Leucovorin
- Facial flushing
- Nausea
- Vomiting
Serious Side Effects of Calcium Folinate:
- Hives
- Difficulty breathing
- Swelling of your face, lips, tongue, or throat
- Severe dizziness
Form and Strength
Leucovorin (Calcium Folinate) is available in the following forms and strengths:
Leucovorin: Tablet
- 5 mg
Caution
- If you are planning to take Leucovorin, it is important to inform your doctor or pharmacist if you are allergic to the medication, levoleucovorin, folic acid, or folinic acid, or if you have any other allergies. To obtain more details about the medication, you can consult your pharmacist.
- Elderly patients receiving weekly leucovorin and fluorouracil may experience severe enterocolitis, diarrhea, and dehydration, which may be fatal. Some patients also experience concomitant granulocytopenia and fever. Additionally, the use of Leucovorin may enhance the toxicity of fluorouracil.
- If you are planning to use Leucovorin, inform your doctor or pharmacist of your medical history, especially if you have certain types of anemia caused by vitamin B12 deficiency. This is because Leucovorin may have interactions or effects specific to these conditions.
- If you are pregnant or planning to become pregnant and you have been prescribed Leucovorin, discuss the potential risks and benefits of its use with your doctor.
- Leucovorin should be given as soon as possible in the treatment of accidental overdosage of folic acid antagonists, such as methotrexate (MTX). The effectiveness of leucovorin in counteracting hematologic toxicity decreases as the time interval between antifolate administration and leucovorin rescue increases.
Frequently Asked Questions (FAQ)
How is Leucovorin administered?
Leucovorin can be administered as an injection, either intravenously or intramuscularly, or as an oral tablet.
Can Leucovorin be taken with other medications?
It can interact with certain medications, and inform your doctor about all medications, vitamins, and supplements you are taking.
How should Leucovorin be stored?
It should be stored at room temperature, away from moisture and heat.
Is Leucovorin safe for use during pregnancy?
Leucovorin is classified as a pregnancy category C drug, which means that its safety during pregnancy has not been established.
How often is Leucovorin administered?
The frequency of Leucovorin administration will depend on the specific treatment regimen being used.
Resources
- https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=33663425-4731-4977-9127-9e59b6b91497&type=display
- https://reference.medscape.com/drug/leucovorin-343736
- https://www.medicinenet.com/leucovorin-oral/article.htm
- https://www.rxlist.com/leucovorin-drug.htm#indications
- https://www.drugs.com/pro/leucovorin-tablets.html
REVIEWS