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Sumatriptan

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Imitrex Nasal Spray (sumatriptan) is a prescription medication used to treat acute migraine attacks with or without aura in adults.

Migraine is a neurological condition that causes recurring headaches, often accompanied by nausea, vomiting, and sensitivity to light or sound. Migraine pain may be moderate to severe and can interfere with everyday activities.

Imitrex Nasal Spray contains sumatriptan, an active ingredient belonging to a class of medications called triptans, also known as selective serotonin receptor agonists.

Sumatriptan works by activating specific serotonin receptors involved in migraine attacks. This helps narrow certain blood vessels and reduce the release of substances that contribute to migraine pain.

Imitrex Nasal Spray is administered through the nose, making it an option for people who have difficulty swallowing tablets or experience nausea during a migraine attack.

The medication is intended to treat migraine symptoms after an attack begins. It does not prevent future migraines or reduce how often they occur.

Treatment of Acute Migraine Attacks

Imitrex Nasal Spray is indicated for the acute treatment of migraine headaches with or without aura in adults.

A migraine attack involves changes in nerve signaling and the activation of pain pathways in the head. These processes can trigger the release of inflammatory substances and cause moderate-to-severe headache pain.

Migraine symptoms vary between individuals. Some people experience throbbing pain on one side of the head, while others may have pain affecting both sides.

Common migraine symptoms include:

  • Moderate to Severe Headache: Throbbing or pulsating pain that may become worse during physical activity.
  • Nausea: Feeling sick to your stomach during a migraine attack.
  • Vomiting: Some people experience vomiting, making oral medications difficult to take.
  • Sensitivity to Light: Bright lights may increase headache discomfort.
  • Sensitivity to Sound: Everyday noises may become uncomfortable or painful.
  • Visual Disturbances: Some people experience flashing lights, blind spots, or zigzag patterns before or during a migraine.
  • Difficulty Concentrating: Migraine pain and associated symptoms may make normal activities more difficult.

Imitrex Nasal Spray helps relieve migraine symptoms by acting on serotonin receptors involved in migraine pain pathways.

Treatment may provide several benefits:

  • Relieves Migraine Headache Pain: Helps reduce headache severity after an attack begins.
  • Reduces Associated Symptoms: May improve nausea and sensitivity to light or sound.
  • Provides a Non-Oral Treatment Option: Allows medication to be administered through the nose instead of swallowing a tablet.
  • Helps Restore Daily Function: Successful migraine relief may make it easier to return to normal activities.

Imitrex Nasal Spray may be particularly useful for people who experience nausea or vomiting during migraines.

However, not everyone responds to sumatriptan, and some migraine attacks may require a different treatment.

Your healthcare provider will determine whether Imitrex Nasal Spray is appropriate based on your migraine symptoms, medical history, and other medications.

Migraine With Aura

Imitrex Nasal Spray may be used to treat migraine attacks that occur with aura.

Migraine aura involves temporary neurological symptoms that develop before or during a migraine attack.

These symptoms may affect vision, sensation, or speech.

Common examples include seeing flashing lights, zigzag lines, shimmering spots, or temporary blind spots.

Some people may also experience tingling or numbness affecting the face or hands.

Aura symptoms typically develop gradually and often last between five and 60 minutes.

Imitrex Nasal Spray is used to treat the headache phase of a migraine attack. It is generally recommended when migraine headache pain begins rather than during aura alone.

The medication does not specifically prevent aura symptoms from occurring.

Tell your healthcare provider if you experience new, unusual, or changing neurological symptoms, particularly weakness, difficulty speaking, or sudden vision loss, because these may require urgent medical evaluation.

Migraine Without Aura

Imitrex Nasal Spray is also indicated for migraine attacks that occur without aura.

Migraine without aura is characterized by recurring headache episodes that may involve throbbing pain, nausea, and sensitivity to light or sound.

The pain may affect one or both sides of the head and can become worse during routine physical activity.

Unlike migraine with aura, these attacks do not involve the typical temporary neurological warning symptoms.

Imitrex Nasal Spray helps relieve the headache and associated symptoms after the migraine begins.

For best results, follow your healthcare provider’s instructions about when to administer the nasal spray during an attack.

Can Imitrex Nasal Spray Treat Cluster Headaches?

Imitrex Nasal Spray is not specifically approved for treating cluster headaches under its U.S. prescribing information.

Cluster headaches are a type of severe headache that usually causes intense pain around one eye or on one side of the head.

The attacks often occur in groups or cycles and may involve tearing, nasal congestion, eyelid swelling, or restlessness.

Although intranasal sumatriptan has shown benefits in clinical studies and is recommended in some international cluster headache guidelines, its safety and effectiveness for this condition have not been established under the U.S. Imitrex Nasal Spray product indication.

Imitrex Injection, a different formulation containing sumatriptan, is approved for the acute treatment of cluster headaches in adults.

Your healthcare provider may recommend an appropriate treatment based on the type and severity of your headaches.

Do not assume that different sumatriptan formulations have the same approved uses. 

How Does Imitrex Nasal Spray Work?

Imitrex Nasal Spray contains sumatriptan, a selective serotonin receptor agonist that targets specific receptors involved in migraine attacks.

Serotonin is a chemical messenger that helps regulate several functions in the nervous system, including pain signaling and blood vessel activity.

Sumatriptan primarily activates serotonin 5-HT1B and 5-HT1D receptors.

These receptors are found on certain blood vessels and nerve endings involved in migraine.

By activating these receptors, sumatriptan helps interrupt processes that contribute to migraine headache pain.

Activates Serotonin Receptors

Sumatriptan binds to specific serotonin receptors known as 5-HT1B and 5-HT1D receptors.

These receptors help regulate blood vessel activity and the release of pain-related chemicals.

When sumatriptan activates these receptors, it produces effects that help relieve an acute migraine attack.

This action distinguishes triptans from ordinary pain relievers such as acetaminophen or ibuprofen.

Narrows Certain Blood Vessels

During migraine attacks, changes in blood vessel activity can contribute to the activation of headache pain pathways.

Sumatriptan activates receptors that cause certain blood vessels to narrow.

This effect, called vasoconstriction, is one of the ways sumatriptan helps relieve migraine pain.

However, migraine is a complex neurological condition, and changes in blood vessel size are only one part of the process.

Because sumatriptan can narrow blood vessels, it is not appropriate for people with certain cardiovascular conditions, including coronary artery disease, a history of stroke, or uncontrolled high blood pressure.

Reduces the Release of Pain-Related Substances

During a migraine attack, nerve endings in the trigeminal system may release substances that contribute to pain signaling.

One important substance is calcitonin gene-related peptide (CGRP), which is involved in migraine-related nerve and blood vessel activity.

Sumatriptan helps reduce the release of certain neuropeptides from trigeminal nerve endings.

This may decrease the activation of pain pathways and help relieve migraine symptoms.

Reduces Migraine Pain Signaling

The trigeminal nerve plays an important role in transmitting pain signals from structures in the head to the brain.

During a migraine attack, this pain system becomes activated.

Sumatriptan helps reduce signalling within these pathways, contributing to headache relief.

As migraine activity decreases, symptoms such as headache pain, nausea, and sensitivity to light or sound may improve.

How Long Does Imitrex Nasal Spray Take to Work?

Imitrex Nasal Spray may begin relieving migraine symptoms within approximately 15 to 30 minutes in some people.

However, the time needed to experience noticeable improvement varies.

Clinical studies commonly assess headache relief two hours after treatment, and not everyone experiences complete pain relief.

The effectiveness of treatment may depend on migraine severity, medication dose, and individual response.

Imitrex Nasal Spray is available in 5 mg and 20 mg single-use nasal spray devices under U.S. prescribing information.

The usual recommended adult dose is 5 mg, 10 mg, or 20 mg, depending on the prescribed treatment.

If migraine symptoms do not resolve or return after initial improvement, your healthcare provider may recommend a second dose, provided at least two hours have passed.

The maximum recommended nasal spray dose is 40 mg within 24 hours.

Do not use more than the prescribed amount. 

Important Information About Imitrex Nasal Spray

Imitrex Nasal Spray is intended for treating acute migraine attacks and should not be used to prevent future migraines.

The medication should only be used when a healthcare provider has established a clear migraine diagnosis.

Do not use Imitrex Nasal Spray if you have certain cardiovascular conditions, including coronary artery disease, uncontrolled hypertension, a history of stroke, or specific blood vessel disorders.

Tell your healthcare provider about all prescription medications, over-the-counter drugs, and supplements you take.

Imitrex Nasal Spray should not be used within 24 hours of another triptan or an ergot-containing migraine medication.

It is also contraindicated with monoamine oxidase-A (MAO-A) inhibitors and within two weeks of stopping them.

Using migraine medications too frequently may cause medication-overuse headaches, making headaches more frequent or difficult to manage.

Seek emergency medical attention if you experience chest pain, sudden weakness, difficulty speaking, or symptoms suggesting a stroke or serious heart problem.

Imitrex Nasal Spray helps relieve acute migraine attacks by activating serotonin receptors, reducing certain pain-related signals, and narrowing specific blood vessels. It is intended for migraine relief rather than headache prevention, and the nasal spray is not specifically approved in the United States for cluster headaches.

Imitrex Nasal Spray is a prescription medication used to treat acute migraine attacks with or without aura in adults.

Imitrex contains sumatriptan, a medication belonging to a class of drugs called triptans, or selective serotonin receptor agonists. It works by activating certain serotonin receptors involved in migraine pain, helping relieve headaches and associated symptoms such as nausea and sensitivity to light or sound.

Imitrex Nasal Spray is administered directly into the nose using a single-use spray device. This provides a treatment option for people who have difficulty swallowing tablets or experience nausea and vomiting during migraine attacks.

The medication should be used when a migraine headache begins, following the dosage prescribed by your healthcare provider.

Imitrex Nasal Spray is intended to treat existing migraine attacks. It does not prevent future migraines and should not be used as a daily preventive medication.

How to Apply Imitrex Nasal Spray

Follow these steps to use Imitrex Nasal Spray correctly and safely:

  1. Prepare the nasal spray: Keep the spray device in its sealed packaging until you are ready to use it. Remove it only when you are prepared to administer the medication.
  2. Gently blow your nose: Clear your nostrils before using the spray. Avoid blowing too forcefully, as this may irritate the inside of your nose.
  3. Sit or stand upright: Keep your head in a comfortable, upright position. You may tilt your head back slightly while positioning the device, but avoid leaning your head too far backward.
  4. Close one nostril: Use your finger to gently press against one side of your nose, closing that nostril.
  5. Insert the spray nozzle: Carefully place the tip of the nasal spray device into your open nostril. Avoid pushing the nozzle too far inside.
  6. Breathe in gently: Begin breathing in through your nose while pressing the plunger firmly to release the full prescribed dose.
  7. Remove the spray nozzle: After administering the medication, remove the nozzle from your nostril and keep your head upright.
  8. Breathe normally: Gently breathe in through your nose and out through your mouth for approximately 10 to 20 seconds.
  9. Avoid blowing your nose immediately: Allow the medication to remain inside your nose. Follow your product instructions about when you can blow your nose again.
  10. Discard the used device: Each Imitrex Nasal Spray device contains one dose and is intended for single use only. Dispose of it safely after administration.

You may notice a slight wet feeling inside your nose or an unusual taste in your mouth after using the spray.

These effects are generally temporary and do not necessarily mean the medication was administered incorrectly.

Do not test, prime, or press the spray plunger before use. The device contains only one dose, and testing it may cause you to lose some or all of the medication.

Recommended Dosage of Imitrex Nasal Spray

The recommended dosage depends on the severity of your migraine symptoms, previous response to treatment, and the instructions provided by your healthcare provider.

Imitrex Nasal Spray is available in 5 mg and 20 mg single-use devices under U.S. prescribing information.

Dosage information General instructions
Medication Imitrex Nasal Spray (sumatriptan)
Dosage form Single-use nasal spray
Available strengths 5 mg and 20 mg
Recommended adult dose 5 mg, 10 mg, or 20 mg
Administration route Intranasal
Second dose At least 2 hours after the first dose, when appropriate
Maximum daily dosage 40 mg within 24 hours
Treatment purpose Acute migraine attacks

A 10 mg dose may require one 5 mg spray in each nostril, according to the prescribed product instructions.

A 20 mg dose is generally administered using one 20 mg nasal spray device in a single nostril.

If your migraine returns after initially improving, a second dose may be taken at least two hours after the first dose, within the prescribed daily limit.

If your migraine does not improve at all after the first dose, do not automatically take a second dose for the same attack. Contact your healthcare provider for advice.

Do not exceed the maximum prescribed dosage or use the medication more frequently than recommended.

Important Tips When Using Imitrex Nasal Spray

Use Imitrex When Migraine Headache Begins

Imitrex Nasal Spray is intended to relieve an existing migraine attack.

For best results, use the medication as directed when you recognize the start of a migraine headache.

Migraine symptoms may include throbbing head pain, nausea, sensitivity to light, and sensitivity to sound.

Some people experience an aura before the headache begins. This may involve flashing lights, zigzag patterns, or temporary visual disturbances.

Imitrex Nasal Spray is generally used during the headache phase rather than to prevent an attack during aura alone.

Do not use the medication for ordinary tension headaches or other headache conditions unless your healthcare provider has confirmed that it is appropriate.

Do Not Prime the Nasal Spray

Imitrex Nasal Spray comes in a premeasured, single-use device.

Unlike some nasal sprays that require priming, Imitrex is designed to deliver its dose with one activation.

Do not press the plunger before placing the nozzle inside your nostril.

Testing or priming the device may release the medication before it reaches your nose.

Once the spray has been activated, the device cannot be reused.

Always open a new device for each prescribed dose.

Use the Correct Breathing Technique

Proper breathing helps administer the medication into the nasal passage.

Before applying the spray, gently clear your nostrils and position the nozzle comfortably.

Close the opposite nostril and breathe in gently while pressing the plunger.

Avoid sniffing forcefully because this may cause more medication to travel toward the throat.

After administration, keep your head upright and breathe gently through your nose and mouth for approximately 10 to 20 seconds.

A bitter or unusual taste may occur if some medication reaches the back of your throat. This is a known effect of intranasal sumatriptan.

Avoid Taking Extra Doses Without Medical Advice

Using more Imitrex Nasal Spray than prescribed may increase your risk of serious side effects.

Sumatriptan can affect blood vessels and may cause unwanted effects involving the heart, blood pressure, or nervous system.

Do not use extra doses because your migraine is particularly painful.

If the first dose provides no improvement, contact your healthcare provider before using another dose for the same attack.

If your headache improves and later returns, your healthcare provider may allow another dose after at least two hours.

Do not exceed 40 mg within 24 hours under the U.S. dosing instructions.

Avoid Medication-Overuse Headaches

Using migraine medications too frequently may cause medication-overuse headaches, also called rebound headaches.

Medication-overuse headaches can develop when certain migraine treatments, including triptans such as sumatriptan, are used on 10 or more days per month for an extended period.

Instead of improving migraine control, frequent medication use may cause headaches to become more common or difficult to manage.

Possible warning signs include headaches occurring more frequently, needing migraine medication more often, or noticing that your usual treatment is becoming less effective.

Keep track of how many days each month you use Imitrex Nasal Spray.

If you need migraine medication frequently, contact your healthcare provider. You may benefit from a preventive migraine treatment rather than relying on additional doses of medication for individual attacks.

The safety of treating an average of more than four headaches within a 30-day period with Imitrex Nasal Spray has not been established. 

What Should I Do If Imitrex Nasal Spray Does Not Work?

If Imitrex Nasal Spray does not provide any relief after your first dose, do not automatically take another dose for the same migraine attack.

A second dose should only be considered when there has been some response to the first dose, and at least two hours have passed.

If your migraine remains severe or does not improve, contact your healthcare provider for advice.

Your healthcare provider may review your symptoms, confirm your migraine diagnosis, or recommend a different treatment.

Do not use additional sumatriptan or combine it with another triptan or ergot-containing migraine medication within 24 hours.

When to Contact Your Healthcare Provider

Contact your healthcare provider if your migraine symptoms do not improve, your headaches become more frequent, or you need Imitrex Nasal Spray more often than prescribed.

You should also report persistent nasal irritation, severe dizziness, unusual weakness, or other symptoms that develop after treatment.

Seek emergency medical attention if you experience severe chest pain, sudden weakness on one side of your body, difficulty speaking, or sudden vision changes.

Imitrex Nasal Spray works best when used correctly at the beginning of a migraine headache. Following the prescribed dose, using the nasal spray device properly, and avoiding frequent medication use can help relieve migraine symptoms while reducing the risk of complications.

Common Side Effects of Imitrex Nasal Spray (Sumatriptan):

  • Dizziness
  • Drowsiness
  • Feeling hot or cold
  • Numbness or tingling
  • Pain, burning, numbness, or tingling in your nose or throat after using the nasal medicine and
  • Pain or tightness in your chest, throat, or jaw
  • Pressure in any part of your body
  • Runny or congested nose after using the nasal medicine
  • Unpleasant taste after using the nasal medicine
  • Weakness

Serious Side Effects of Imitrex Nasal Spray (Sumatriptan):

  • Agitation
  • Burning pain in your legs or feet
  • Cold feeling in your legs or feet
  • Color changes in your legs or feet
  • Diarrhea with or without the presence of blood
  • Difficulty seeing
  • Fever
  • Hallucinations
  • Hip pain
  • Irregular heartbeats
  • Leg cramps
  • Loss of coordination
  • Muscle stiffness
  • Nausea
  • Numbness or tingling in your legs or feet
  • Pain in your jaw or shoulder
  • Poor balance and
  • Seizure (convulsions)
  • Severe chest pain
  • Shortness of breath
  • Slurred speech
  • Sudden numbness or weakness on one side of the body
  • Sudden severe headache
  • Sudden severe stomach pain
  • Sweating or shivering
  • Vomiting

Imitrex Nasal Spray (Sumatriptan) is available in the following forms and strength:

Imitrex Nasal Spray: Nasal Spray

  • 5 mg
  • 20 mg

Before using Imitrex Nasal Spray, tell your healthcare provider about any medical conditions, allergies, or medications you are taking.

Imitrex Nasal Spray is a prescription medication used to treat acute migraine attacks with or without aura in adults. It belongs to a class of medications called triptans, also known as selective serotonin receptor agonists.

Sumatriptan works by activating specific serotonin receptors involved in migraine attacks. This helps reduce migraine-related pain signals and narrows certain blood vessels.

Although Imitrex Nasal Spray can help relieve migraine symptoms, it may cause serious side effects in people with certain medical conditions.

People with heart disease, blood circulation problems, uncontrolled high blood pressure, or a history of stroke should not use this medication.

Your healthcare provider will review your medical history and determine whether Imitrex Nasal Spray is appropriate for you.

Seizures and Epilepsy

Imitrex Nasal Spray should be used with caution in people with epilepsy or a history of seizures.

A seizure occurs when abnormal electrical activity in the brain causes temporary changes in movement, awareness, sensation, or behavior.

Seizures have been reported in some people taking sumatriptan, including individuals with a history of epilepsy and those without known seizure disorders.

People with a lowered seizure threshold may be more likely to experience seizures. A lowered seizure threshold means that the brain is more susceptible to abnormal electrical activity.

Tell your healthcare provider if you have epilepsy, a history of seizures, or another neurological condition before using Imitrex Nasal Spray.

Your healthcare provider will assess whether the potential benefits of migraine treatment outweigh the risks.

Do not stop taking your prescribed seizure medications without medical advice.

Seek emergency medical attention if you experience a seizure lasting five minutes or longer, repeated seizures without recovery, or a first-time seizure.

High Blood Pressure (Hypertension)

Imitrex Nasal Spray may increase blood pressure in some individuals.

Sumatriptan works partly by narrowing certain blood vessels. This action can affect blood pressure and may increase the workload on the heart.

People with hypertension should tell their healthcare provider before using this medication.

If your blood pressure is well controlled, your healthcare provider may determine that Imitrex Nasal Spray is appropriate after assessing your cardiovascular health.

However, Imitrex Nasal Spray must not be used by people with uncontrolled high blood pressure.

In rare cases, sumatriptan may cause a serious increase in blood pressure, including a hypertensive crisis.

Possible symptoms of severely elevated blood pressure include:

  • Severe Headache: A sudden or unusually intense headache.
  • Blurred Vision: Changes in eyesight or difficulty seeing clearly.
  • Chest Pain: Pressure, tightness, or discomfort in the chest.
  • Shortness of Breath: Difficulty breathing normally.
  • Confusion: Sudden difficulty thinking clearly or remaining alert.

Your healthcare provider may recommend monitoring your blood pressure before and during treatment.

Seek emergency medical attention if you experience symptoms of a hypertensive emergency, particularly severe chest pain, neurological changes, or significant breathing difficulties.

Coronary Artery Disease and Other Heart Conditions

Imitrex Nasal Spray should not be used by people with certain cardiovascular conditions, including ischemic coronary artery disease or coronary artery vasospasm.

Coronary artery disease occurs when the blood vessels supplying the heart become narrowed or blocked, reducing blood flow to the heart muscle.

Because sumatriptan can narrow blood vessels, it may worsen reduced blood flow in people with coronary artery disease.

This can increase the risk of serious complications, including chest pain, abnormal heart rhythms, or a heart attack.

Imitrex Nasal Spray is contraindicated in people with:

  • Coronary Artery Disease: Narrowing or blockage of the arteries supplying blood to the heart.
  • History of Heart Attack: Previous damage to the heart muscle caused by reduced blood flow.
  • Prinzmetal’s Angina: A condition involving spasms of the coronary arteries that can cause sudden chest pain.
  • Certain Heart Rhythm Disorders: Including Wolff-Parkinson-White syndrome and arrhythmias associated with accessory electrical pathways.

If you have multiple cardiovascular risk factors, such as diabetes, smoking, high blood pressure, high cholesterol, obesity, or a strong family history of heart disease, your healthcare provider may recommend a cardiovascular evaluation before prescribing sumatriptan.

Some people experience temporary pressure or tightness in the chest, throat, neck, or jaw after taking sumatriptan. Although these sensations are often not caused by heart disease, they should not automatically be considered harmless.

Seek emergency medical attention if you develop severe or persistent chest pain, shortness of breath, fainting, or an irregular heartbeat.

For more information about chest pain caused by reduced blood flow to the heart, see angina. 

Peripheral Vascular Disease

Imitrex Nasal Spray should not be used by people with peripheral vascular disease.

Peripheral vascular disease affects blood vessels outside the heart and brain, particularly those supplying the arms and legs.

The condition may reduce blood circulation and cause pain, numbness, or weakness in the affected areas.

Sumatriptan can narrow certain blood vessels, potentially worsening existing circulation problems.

Possible symptoms of reduced blood flow include:

  • Leg Pain: Pain or cramping during walking.
  • Cold Hands or Feet: Reduced circulation may cause the extremities to feel unusually cold.
  • Numbness or Tingling: Changes in blood supply may affect sensation.
  • Skin Color Changes: Fingers or toes may appear unusually pale or bluish.
  • Poor Wound Healing: Cuts or sores may take longer than expected to heal.

Imitrex Nasal Spray is also contraindicated in people with ischemic bowel disease, a condition caused by reduced blood flow to the intestines.

Contact your healthcare provider immediately if you develop new circulation-related symptoms after using sumatriptan.

Seek urgent medical attention if you experience severe abdominal pain with bloody diarrhea or sudden pain and color changes in a limb.

Hemiplegic and Basilar Migraine

Imitrex Nasal Spray should not be used by people with a history of hemiplegic or basilar migraine, according to its prescribing information.

These are uncommon forms of migraine associated with specific neurological symptoms.

Hemiplegic migraine may cause temporary weakness affecting one side of the body.

Basilar migraine, now commonly called migraine with brainstem aura, may involve symptoms such as dizziness, double vision, difficulty speaking, or problems with balance.

These symptoms can resemble those of a stroke.

Because sumatriptan can narrow blood vessels, its use is contraindicated in people with these migraine types under current product labeling.

The medication is also contraindicated in people who have previously experienced a stroke or transient ischemic attack (TIA), sometimes called a mini-stroke.

Possible warning signs of a stroke include sudden weakness on one side of the body, facial drooping, difficulty speaking, loss of balance, or changes in vision.

Seek emergency medical attention immediately if you experience sudden neurological symptoms, even if you believe they are related to a migraine.

Your healthcare provider may recommend a different acute migraine treatment that does not cause blood vessel narrowing. 

Liver Problems (Hepatic Impairment)

Tell your healthcare provider if you have liver disease or a history of reduced liver function before using Imitrex Nasal Spray.

The liver helps process sumatriptan after it enters the bloodstream.

When liver function is impaired, the body may process the medication differently, potentially increasing medication exposure.

People with mild or moderate liver impairment may require additional precautions.

However, Imitrex Nasal Spray should not be used by people with severe hepatic impairment.

Your healthcare provider will assess your liver condition and determine whether another migraine treatment is more appropriate.

Tell your healthcare provider if you have cirrhosis, chronic hepatitis, or another significant liver disorder.

Do not increase your prescribed sumatriptan dosage without medical advice.

Kidney Problems (Renal Impairment)

Tell your healthcare provider if you have kidney disease or reduced kidney function before using Imitrex Nasal Spray.

The kidneys help eliminate some sumatriptan and its metabolites from the body.

Although kidney impairment is not a listed contraindication for Imitrex Nasal Spray, information about its use in people with significant kidney disease is limited.

Your healthcare provider may consider your overall medical condition, other medications, and cardiovascular risk factors when deciding whether treatment is appropriate.

Kidney disease can also occur alongside high blood pressure, diabetes, or vascular disorders, which may affect the safety of sumatriptan.

Do not change your dosage without consulting your healthcare provider.

Serotonin Syndrome

Imitrex Nasal Spray may rarely contribute to serotonin syndrome, a potentially serious condition caused by excessive serotonin activity in the nervous system.

Serotonin is a chemical messenger involved in several body functions, including mood regulation, digestion, and pain signalling.

Sumatriptan activates certain serotonin receptors to relieve migraine symptoms.

The risk of serotonin syndrome may increase when sumatriptan is combined with medications that affect serotonin levels.

These may include:

  • Selective Serotonin Reuptake Inhibitors (SSRIs): Such as sertraline, fluoxetine, and escitalopram.
  • Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs): Such as venlafaxine and duloxetine.
  • Tricyclic Antidepressants: Certain medications used to treat depression or chronic pain.
  • Other Serotonergic Medications: Certain pain medications and other drugs that affect serotonin activity.

Possible symptoms of serotonin syndrome include:

  • Agitation: Unusual restlessness, confusion, or irritability.
  • Rapid Heartbeat: A faster-than-normal heart rate.
  • High Body Temperature: Fever or excessive sweating.
  • Muscle Twitching: Involuntary muscle movements or tremors.
  • Muscle Stiffness: Unusual tightness or rigidity.
  • Diarrhea: Frequent loose bowel movements.
  • Changes in Blood Pressure: Blood pressure may increase or become unstable.

Symptoms may develop within minutes to hours after starting or increasing a serotonergic medication.

Using an SSRI or SNRI does not automatically mean you cannot take Imitrex. Your healthcare provider will assess your individual risk and determine whether the combination is appropriate.

Stop using Imitrex Nasal Spray and seek urgent medical attention if you develop symptoms suggesting serotonin syndrome.

Severe symptoms, including high fever, confusion, or seizures, require emergency medical care. 

Use in Older Adults

Older adults may require additional precautions when using Imitrex Nasal Spray.

Although age alone does not automatically prevent sumatriptan use, older individuals are more likely to have cardiovascular disease, high blood pressure, or other conditions that may increase treatment risks.

Sumatriptan can affect blood vessels and blood pressure, making cardiovascular health an important consideration.

People aged 65 years and older may also take several medications, increasing the possibility of drug interactions.

The safety and effectiveness of Imitrex Nasal Spray have not been adequately established in older adults.

Your healthcare provider may recommend a cardiovascular evaluation before prescribing sumatriptan, particularly if you have risk factors for heart disease.

Your medical history, other medications, and general health will help determine whether Imitrex Nasal Spray is appropriate.

Allergic Reactions and Hypersensitivity

Do not use Imitrex Nasal Spray if you have a known allergy to sumatriptan or any other ingredient in the medication.

Allergic reactions to sumatriptan may range from mild skin symptoms to severe, potentially life-threatening reactions.

Possible symptoms include:

  • Skin Rash: Red or irritated patches on the skin.
  • Itching: Persistent itching or discomfort.
  • Hives: Raised, itchy bumps that may appear suddenly.
  • Facial Swelling: Swelling of the lips, eyelids, or face.
  • Throat Tightness: Difficulty swallowing or breathing.
  • Wheezing: Noisy breathing caused by narrowed airways.

Severe allergic reactions, including anaphylaxis, have been reported with sumatriptan.

Tell your healthcare provider if you have previously experienced allergic reactions to sumatriptan or other migraine medications.

Stop using Imitrex Nasal Spray and seek emergency medical attention if you develop difficulty breathing, swelling of your tongue or throat, or signs of anaphylaxis.

Other Medication Interactions

Certain medications should not be taken close to Imitrex Nasal Spray because they may increase the risk of serious side effects.

Do not use Imitrex Nasal Spray within 24 hours of another triptan, such as rizatriptan or zolmitriptan, or an ergot-containing migraine medication, such as ergotamine or dihydroergotamine.

Combining these medications may increase blood vessel narrowing and raise the risk of cardiovascular complications.

Imitrex Nasal Spray must also not be used while taking a monoamine oxidase-A (MAO-A) inhibitor or within two weeks after stopping one.

These medications can increase sumatriptan exposure and the risk of adverse reactions.

Before starting Imitrex Nasal Spray, tell your healthcare provider or pharmacist about all prescription medications, over-the-counter drugs, and supplements you take.

Do not combine migraine medications or adjust their timing without medical advice. 

When to Contact Your Healthcare Provider

Contact your healthcare provider if you experience persistent dizziness, unusual weakness, frequent palpitations, worsening migraines, or other unexpected symptoms after using Imitrex Nasal Spray.

Tell your healthcare provider if you develop high blood pressure, new heart problems, liver disease, kidney problems, or changes in your seizure condition.

Seek emergency medical attention if you experience severe chest pain, sudden weakness affecting one side of your body, difficulty speaking, significant vision changes, or symptoms of a serious allergic reaction.

Imitrex Nasal Spray can help relieve acute migraine attacks, but it is not suitable for everyone. Understanding the risks associated with cardiovascular disease, certain migraine types, seizures, and medication interactions can help support safer treatment.

How Quickly Does Imitrex Nasal Spray Work for Migraines or Cluster Headaches?

Imitrex Nasal Spray may begin relieving migraine symptoms within approximately 15 to 30 minutes after administration. However, the time needed to experience noticeable improvement varies from person to person. Imitrex belongs to a class of medications called triptans, which work by activating specific serotonin receptors involved in migraine attacks. This helps reduce migraine-related pain signals and relieve symptoms such as headache, nausea, and sensitivity to light or sound. Some people may notice improvement shortly after using the spray, while others may require up to two hours to experience significant headache relief. The effectiveness of treatment depends on factors such as migraine severity, the prescribed dose, and your individual response. Although sumatriptan is also used to treat cluster headaches, Imitrex Nasal Spray is not specifically approved for cluster headaches in the United States. Imitrex Injection is a different formulation that is approved for this condition. If your migraine does not improve after the first dose, contact your healthcare provider before taking another dose. 

How Often Can I Use Imitrex Nasal Spray for Acute Migraines or Cluster Headaches?

Imitrex Nasal Spray should only be used when needed to treat an acute migraine attack and according to your healthcare provider’s instructions. The recommended adult dose is 5 mg, 10 mg, or 20 mg, depending on your prescribed treatment. If your migraine improves but later returns, or you experience only partial relief, your healthcare provider may recommend a second dose. Wait at least two hours between doses and do not exceed 40 mg within 24 hours. If the first dose provides no relief, contact your healthcare provider before taking another dose for the same migraine attack. The safety of treating an average of more than four headaches within a 30-day period with Imitrex Nasal Spray has not been established. Using triptans on 10 or more days per month for an extended period may also increase the risk of medication-overuse headaches, sometimes called rebound headaches. Medication-overuse headaches occur when frequent use of acute headache medications contributes to more frequent or persistent headaches. If you need Imitrex Nasal Spray frequently or notice that your migraines are becoming more common, contact your healthcare provider. You may benefit from a preventive migraine treatment. Do not increase the dosage or frequency without medical advice. 

Can I Drive or Operate Heavy Machinery After Taking Imitrex Nasal Spray?

Imitrex Nasal Spray may cause dizziness, drowsiness, weakness, or tiredness in some people. These side effects may affect your ability to concentrate, react quickly, or perform tasks that require coordination and alertness. Migraine attacks themselves can also cause dizziness, visual disturbances, and difficulty concentrating, which may make driving unsafe. Avoid driving, operating heavy machinery, or performing potentially dangerous activities if you experience these symptoms. If you are using Imitrex Nasal Spray for the first time, pay attention to how your body responds before performing activities that require full alertness. Do not drive until your symptoms have resolved and you feel fully alert. If dizziness or drowsiness becomes severe, persistent, or occurs with chest discomfort or fainting, seek medical attention. Tell your healthcare provider if these effects interfere with your normal activities or occur repeatedly after treatment. 

How Should I Store Imitrex Nasal Spray?

Imitrex Nasal Spray should be stored in a cool, dry place away from excessive heat and direct sunlight. According to the U.S. prescribing information, the recommended storage temperature is between 2°C and 30°C (36°F and 86°F). Keep the medication in its original packaging to protect it from light and prevent accidental activation. Avoid storing Imitrex Nasal Spray in places exposed to high humidity or frequent temperature changes, such as bathrooms. Each nasal spray device contains a single premeasured dose of sumatriptan and is intended for one-time use only. Do not remove the device from its packaging until you are ready to use it. Do not test or prime the spray before administration because this may release the medication and cause you to lose the dose. After using the spray, dispose of the device safely according to the manufacturer’s instructions. Do not attempt to refill or reuse it. Keep Imitrex Nasal Spray out of the reach of children and pets, and do not use it after the expiration date printed on the packaging. Proper storage helps maintain the medication’s quality and ensures the nasal spray is ready when you need treatment for a migraine attack. 

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Additional Information Book
Generic name:

Sumatriptan

Formulation:

Nasal Spray, Nasal spray

Strength(s):

5mg, 20mg

Quantities Available:

2doses, 4doses

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Our online Canadian Pharmacy is known for high standards of quality, safety, and efficiency when it comes to medications.

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How to Order

How much Imitrex Nasal Spray can I order at once from a Canadian pharmacy?

When ordering Imitrex Nasal Spray (sumatriptan) from a Canadian pharmacy, you can typically purchase up to a 90-day supply at one time, which is common for prescription medications to ensure adequate management of chronic conditions without frequent refills.

Here’s what you need to know:

Dosage and Quantity: Imitrex Nasal Spray is commonly prescribed in 5 mg or 20 mg dosage per spray. For a 90-day supply, if the maximum recommended dosage is one spray up to twice a day, this means you would order up to 180 sprays (90 days x 2 sprays per day).

Do you sell sumatriptan?

No, we do not sell sumatriptan directly on our website. However, you can still enjoy low prices on Imitrex Nasal Spray, which contains sumatriptan as an active ingredient. To purchase Imitrex Nasal Spray, you will need a valid prescription from your healthcare provider. We require this prescription to dispense the medication safely and appropriately. You can submit your prescription by mailing it to us, faxing it, or uploading it through your online account.

Do you offer shipping of Imitrex Nasal Spray (sumatriptan) to the United States?

Yes, we ship Imitrex Nasal Spray (sumatriptan) to both the United States and Puerto Rico.

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Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Imitrex Nasal Spray (Sumatriptan). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Imitrex Nasal Spray (Sumatriptan).