Indications
Glyset (generically known as miglitol) is an oral medication used in the management of non-insulin-dependent diabetes mellitus (NIDDM or type 2 diabetes). It works as an alpha-glucosidase inhibitor, delaying the digestion of carbohydrates in the body and reducing the amount of sugar that passes into the bloodstream after a meal.
Glyset is meant to be used in conjunction with proper diet and exercise to control high blood sugar levels. Glyset is not intended for use in patients with type 1 diabetes or diabetic ketoacidosis, nor is it a substitute for insulin or other diabetes medications.
Use and Dosage
Glyset comes as a tablet to take by mouth as directed by your doctor, usually three times daily with the first bite of a meal. The dosage is based on your medical condition, kidney function, and response to treatment.
The recommended starting dosage of Miglitol is 25 mg, given orally three times daily at the start of each main meal. However, some patients may benefit by starting at a lower dose and titrating up as needed to minimize gastrointestinal side effects. It is important to follow your doctor's instructions carefully and not take more or less than the prescribed dosage.
Follow your doctor's instructions carefully and do not take more or less of the medication than prescribed. Additionally, it is important to continue monitoring your blood sugar levels regularly as directed by your doctor while taking Glyset. If you have any questions or concerns about using this medication, please speak with your doctor or pharmacist.
Side Effects
Common Side Effects of Glyset (Miglitol):
- Bloated full feeling
- Diarrhea
- Excess air or gas in the stomach or intestines
- Increase in bowel movements
- Loose stools
- Mild rash
- Passing gas
- Soft stools
- Stomach discomfort
Serious Side Effects of Glyset (Miglitol):
- Bloody or tarry stools
- Constipation
- Diarrhea that contains blood or mucus
- Difficulty breathing
- Hives
- Rectal bleeding
- Severe diarrhea
- Severe diarrhea or constipation
- Stomach or abdomen pain
- Swelling of your face, lips, tongue, or throat
Forms and Strength
Glyset (Miglitol) is available in the following forms and strength:
Miglitol: Tablet
- 25 mg
- 50 mg
Cautions
- Allergic reactions: Patients should not take Glyset if they have a known allergy to miglitol or any of its inactive ingredients.
- Digestive problems: Glyset can cause digestive problems such as abdominal pain, diarrhea, flatulence, and bloating. Patients who have severe digestive problems, particularly colonic ulceration, should use Glyset with caution.
- Kidney or liver problems: Patients who have kidney or liver problems should use Glyset with caution.
- Low blood sugar: Glyset may cause hypoglycemia (low blood sugar) when used in combination with other oral anti-diabetic agents or insulin. Patients who are at increased risk for hypoglycemia should use Glyset with caution.
- Pregnancy and breastfeeding: Glyset may not be safe to use during pregnancy or breastfeeding. Women who are pregnant or breastfeeding should speak with their healthcare provider before taking Glyset.
- Diabetic ketoacidosis: Glyset is not recommended for use in patients with type 1 diabetes or diabetic ketoacidosis.
- Surgery and other medical procedures: Glyset can cause digestive problems that may interfere with certain medical procedures, such as colonoscopy. Patients who are scheduled to undergo surgery or other medical procedures should inform their healthcare provider that they are taking Glyset.
- Interactions with other medications: Glyset may interact with other medications, including digoxin, dalteparin, and other medications used to treat diabetes. Patients should inform their healthcare provider of all medications they are currently taking before starting Glyset.
- Dehydration: Patients who are taking Glyset should ensure they remain well hydrated to minimize the risk of dehydration.
- Elderly patients: Elderly patients may be more sensitive to the effects of Glyset and may need to use it with caution.
Frequently Asked Questions (FAQ)
How long does it typically take for Glyset (miglitol) to start working?
Glyset (miglitol) typically starts working immediately upon taking it with a meal by slowing down the digestion and absorption of carbohydrates. However, it may take several weeks for the medication to have its full effect in helping to control blood glucose levels.
Is Glyset (miglitol) effective in treating type 1 diabetes?
Glyset (miglitol) is not effective in treating type 1 diabetes as it works by reducing the digestion and absorption of carbohydrates in the small intestine. Type 1 diabetes involves a lack of insulin production by the pancreas, and typically requires insulin injections for management.
Can Glyset (miglitol) be used in combination with other diabetes medications?
Glyset (miglitol) can be used in combination with other diabetes medications, such as metformin or insulin, to help control blood glucose levels. Your healthcare provider can advise you on the best treatment plan for your individual needs.
What should I do if I miss a dose of Glyset (miglitol)?
If you miss a dose of Glyset (miglitol), take it with the next meal or as soon as possible, unless it is almost time for your next dose. Do not double the dose to make up for the missed one.
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