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Glucovance is a medication used to treat type 2 diabetes in adults. Proper control of diabetes may also lessen your risk of a heart attack or stroke. It is a combination of two drugs, glyburide, and metformin, that work together to help control blood glucose levels. Glyburide belongs to the class of drugs known as sulfonylureas.

Glyburide stimulates insulin release from the pancreas and decreases glucose production by the liver, while metformin reduces glucose production by the liver and improves insulin sensitivity. Together, these actions help control blood glucose levels in people with type 2 diabetes.

Uses and Dosage

Glucovance is an oral tablet medication that is taken with meals as directed by your doctor, usually once or twice daily. Drink plenty of fluids while taking this medication, unless otherwise directed by your doctor. If you are taking colesevelam, take the Glucovance tablet at least 4 hours before taking colesevelam.

The dosage of Glucovance is based on your medical condition and how well you respond to treatment. Your doctor may start you with a low dose and gradually increase it to reduce the risk of side effects, such as upset stomach and low blood sugar. Your doctor will monitor your blood sugar levels and adjust your dose accordingly.

To ensure that you get the maximum benefit from Glucovance, take it regularly and at the same time(s) each day. It may take up to 2 weeks before you experience the full benefits of the tablet. If your condition does not improve or worsens, such as having an abnormally high or low blood sugar, notify your doctor.

Side effect

Common Side Effects of Glucovance (Glyburide/Metformin):

  • Diarrhea
  • Headache
  • Low blood sugar
  • Nausea
  • Upset stomach

Serious Side Effects of Glucovance (Glyburide/Metformin):

  • Blurred vision
  • Confusion
  • Difficulty breathing
  • Dizziness
  • Extreme weakness
  • Feeling cold
  • Hives
  • Irregular heart rate
  • Rapid weight gain
  • Seizures
  • Shortness of breath
  • Stomach pain
  • Sweating
  • Swelling (especially of your face, lips, tongue, or throat)
  • Tiredness
  • Tremors
  • Trouble breathing
  • Trouble speaking
  • Unusual muscle pain
  • Vomiting
  • Weakness

Form and Strength

Glucovance (Glyburide/Metformin) is available in the following forms and strength:

Glucovance: Tablet 

  • 2.5/500mg
  • 5/500mg

Glyburide/Metformin: Tablet

  • 2.5/500mg
  • 5/500mg


  • Glucovance is not recommended during pregnancy. If you are pregnant or planning to become pregnant, you should talk to your healthcare provider about alternative treatment options for managing your diabetes.
  • Glucovance should be used with caution in patients with impaired kidney function, as both glyburide and metformin can affect kidney function. Regular monitoring of kidney function is recommended in such patients.
  • Both glyburide and metformin can cause low blood sugar or hypoglycemia. Patients taking Glucovance should be advised to monitor their blood sugar regularly, especially during the first few weeks of treatment, when the medication dose is being adjusted.
  • Glucovance should be used with caution in patients with a history of heart disease, as it can cause changes in heart rhythm. Patients should be advised to report any irregular heartbeat, chest pain, or shortness of breath to their doctor.
  • Glyburide and metformin can affect liver function and should be used with caution in patients with liver disease. Liver function tests may be recommended in such patients.
  • Avoid drinking alcohol. It lowers blood sugar and may increase your risk of lactic acidosis.

Frequently Asked Questions (FAQ)

How should I take Glucovance?

Glucovance should be taken with meals to reduce the risk of stomach upset. The dosage and frequency of the medication will depend on your individual needs and should be determined by your healthcare provider.

Are there any drug interactions with Glucovance?

Yes, there are many drugs that can interact with Glucovance. You should make sure to inform your healthcare provider of any medications you are currently taking before starting Glucovance.

Is Glucovance safe for everyone with type 2 diabetes?

Glucovance may not be safe for everyone with type 2 diabetes. Discuss your medical history and any other medications you are taking with your healthcare provider before starting treatment with Glucovance.

Can Glucovance be used to treat type 1 diabetes?

No, Glucovance is not effective in treating type 1 diabetes. It is only recommended for use in adults with type 2 diabetes.

Can Glucovance be used in children?

Glucovance is not recommended for use in children. Its safety and effectiveness in this population have not been established.

How long does it take for Glucovance to start working?

The onset of action for Glucovance is typically within 2 hours of taking the medication with a meal.


Additional information

Generic name:

Glyburide/Metformin, Gyburide/Metformin




2.5/500mg, 5/500mg

Quantities Available:

90, 100


Additional Information Book

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Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Glucovance (Glyburide/Metformin). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Glucovance (Glyburide/Metformin).