Colazal (Balsalazide)

Indications

Colazal (generic name balsalazide) is a medication used to treat mildly to moderately active ulcerative colitis in patients 5 years of age and older. It can be used alone or with other medications to reduce symptoms of ulcerative colitis such as diarrhea, rectal bleeding, and stomach pain. Balsalazide belongs to a class of drugs called 5-Amniosalicylic Acid Derivatives. It works by reducing inflammation in the colon.

Uses and Dosage

Colazal (Balsalazide) is available in capsule form and should be taken orally with or without food, as directed by a healthcare provider, usually three times a day. Drink plenty of fluids during treatment with the capsules, unless otherwise directed by a healthcare provider, to help prevent kidney stones. If someone has difficulty swallowing the capsules, they may open them and sprinkle the contents onto a spoonful of applesauce and consume the mixture immediately.

The typical dosing for Colazal (Balsalazide) is based on age, medical condition, and response to treatment.

• In adults, the recommended dose is 2.25 grams (three 750 mg capsules) taken orally, three times daily for up to 12 weeks; the maximum dose should not exceed 6.75 grams (nine 750-mg capsules) per day.
• For children ages 5 to 17, the typical dosage is either 2.25 grams (three 750-mg capsules) taken orally, three times daily for up to 8 weeks; the maximum dose should not exceed 6.75 grams per day, or 750 mg (one capsule) taken orally, three times daily for up to 8 weeks.
• The maximum daily dose is 2.25 grams (or 3 capsules) per day.

Side effect

Common Side Effects of Colazal (Balsalazide):

• Diarrhea
• Fever
• Headache
• Joint pain
• Mild or occasional nausea
• Sneezing
• Sore throat
• Stomach pain
• Stuffy nose
• Vomiting

Serious Side Effects of Colazal (Balsalazide):

• Bloody diarrhea
• clay-colored stools
• Cold hands and feet
• Cramps
• Dark urine
• Difficulty breathing
• Fever
• Hives
• lightheadedness
• Little or no urination
• Loss of appetite
• Pain or burning when you urinate
• Pale skin
• Rapid weight gain
• Shortness of breath
• Stomach pain
• Swelling
• Swelling of your face, lips, tongue, or throat
• Unusual tiredness
• Upper stomach pain
• Yellowing of the skin or eyes (jaundice)

Form and Strength

Colazal (Balsalazide) is available in the following forms and strength:

Colazal: Capsule

• 750 mg

Balsalazide: Capsule

• 750 mg

Caution

• Some people may experience an allergic reaction to balsalazide, which can cause symptoms such as rash, itching, swelling, or difficulty breathing. Seek medical attention immediately if you experience any of these symptoms.
• Colazal can affect liver function in rare cases. If you experience symptoms such as fatigue, abdominal pain, or yellowing of the skin or eyes, contact your doctor immediately.
• Colazal can also affect kidney function in rare cases. If you experience symptoms such as decreased urine output or swelling in the legs or feet, contact your doctor immediately.
• In rare cases, Colazal may cause blood disorders such as anemia or low platelet count. Contact your doctor if you experience symptoms such as fatigue, pale skin, or easy bruising or bleeding.
• Colazal can interact with other medications, talk to your doctor or pharmacist before starting any new medications while taking Colazal.

Frequently Asked Questions (FAQ)

Can I drink alcohol while taking Colazal?

Drink alcohol while taking Colazal. Alcohol can irritate the stomach and interfere with the absorption of the medication.

Can I take other medications while taking Colazal?

There are many medications that can interact with Colazal, talk to your doctor or pharmacist before starting any new medications while taking Colazal.

What should I do if I miss a dose of Colazal?

If you miss a dose of Colazal, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule.

How long does it take for Colazal to start working?

Colazal may take several weeks to start working effectively. Continue taking the medication as prescribed, even if you do not feel immediate relief from your symptoms.

Can Colazal be taken with food?

Yes, Colazal should be taken with food to reduce the risk of stomach upset.

Can Colazal be crushed or split?

Do not crush or split Colazal tablets, as they are designed to release the medication slowly over time.

How should Colazal be stored?

Colazal should be stored at room temperature, away from heat, moisture, and light. The medication should be kept out of reach of children.

Resources

• https://www.mayoclinic.org/drugs-supplements/balsalazide-oral-route/side-effects/drg-20062119?p=1
• https://www.goodrx.com/balsalazide/what-is
• https://www.drugs.com/mtm/colazal.html
• https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/020610s017lbl.pdf
• https://www.webmd.com/drugs/2/drug-20259/colazal-oral/details
• https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=22f41e83-b9fb-4c9e-8cc3-f457034191a8