Clenpiq (Sodium Picosulfate/Magnesium Oxide/Citric Acid)

Indications

Clenpiq is a prescription medicine used to cleanse the bowel prior to diagnostic tests of the colon/ before a colonoscopy. It consists of sodium picosulfate, magnesium oxide, and citric acid which work together to provide relief from uncomfortable symptoms associated with constipation. It works by increasing the amount of water in the intestines and helps break up any stool present in the colon.

Clenpiq is a powerful combination of active ingredients used to treat constipation and bowel cleansing prior to medical procedures. Sodium picosulfate belongs to a class of medications known as stimulant laxatives. When combined with magnesium oxide and anhydrous citric acid, it forms a medication called magnesium citrate, which belongs to a class of medications called osmotic laxatives.

Uses and Dosage

Clenpiq is available in the form of Powder for Oral Solution to be used orally through the mouth. To ensure that Clenpiq Powder for Oral Solution provides the best possible results, it is important to follow the instructions carefully. Start by mixing the powder with 4 ounces of clear liquids such as water, apple juice, clear broth, white cranberry juice, white grape juice, or ginger ale. Immediately after mixing, drink the mixture.

You will need two doses of this medicine. Drink the additional prescribed amount of clear fluids before and after every dose of this medicine, and until at least two hours before your colonoscopy. Additionally, for the best results, do not eat any solid foods or drink any dairy or anything colored red or purple while taking this medicine.

The recommended dosage of Clenpiq Powder for Oral Solution is 10 mg of sodium picosulfate, 3.5 grams of magnesium oxide, and 12 grams of anhydrous citric acid per 16.1 g of powder. For adults and pediatric patients 9 years or older, the Split-Dose regimen is the preferred dosing method and consists of two doses, each provided by 1 bottle (160 mL) of ready-to-drink solution.

Side Effects

Serious Side Effects of Clenpiq

• Allergic reactions
  • Hives
  • Itching
  • Skin rash
  • Swelling of the face, lips, tongue, or throat
• Dehydration
  • Dark yellow or brown urine
  • Dry mouth
  • Feeling faint or lightheaded
  • Headache
  • Increased thirst
• Fast or irregular heartbeat
• Kidney injury
  • Decrease in the amount of urine
  • Swelling of the ankles
• Seizures
• Sudden or severe stomach pain, bloody diarrhea, fever, nausea, vomiting

Common Side Effects of Clenpiq

• Dizziness
• Headache
• Nausea
• Stomach pain

Form and Strength

Clenpiq (Sodium Picosulfate/Magnesium Oxide/Citric Acid) is available in the following forms and strengths:

Clenpiq: Powder for Oral Solution

• 10mg/3.5g/12g

Caution

• Do not take any other laxatives during your treatment with sodium picosulfate, magnesium oxide, and anhydrous citric acid. Doing so may decrease the efficacy of the treatment and increase the risk of side effects. Make sure to follow the instructions given by your doctor or pharmacist and ask any questions if you are unsure.
• If you have ever had any of the conditions associated with inflammatory bowel disease such as Crohn's disease or ulcerative colitis, be sure to mention this to your doctor as these can cause swelling and irritation in the intestine and may increase your risk of heart-related complications.
• Tell your doctor if you have recently had a heart attack, heart failure, an irregular heartbeat, an enlarged heart, a prolonged QT interval, seizures, a low level of sodium in your blood, inflammatory bowel disease, difficulty swallowing, or gastric reflux.
• Inform your doctor if you have been drinking excessive amounts of alcohol or taking medications for anxiety or seizures and are now decreasing your use of these substances.
• Tell your doctor if you have any of these conditions: a blockage in your stomach or intestine, an opening in the wall of your stomach or intestine, toxic megacolon, a condition that stops food and fluid from being emptied from the stomach normally, or kidney disease. Your doctor may advise you not to take sodium picosulfate, magnesium oxide, and anhydrous citric acid.
• Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding, as some medications can pass through breast milk and may cause harm to your baby. some medications may be unsafe to take during pregnancy.

Frequently Asked Questions (FAQ)

How long after taking Clenpiq can I drink?

Drink the first 5.4 oz. bottle of preparation solution. Then drink at least 40 oz. of clear liquids within 5 hours of completion of the Clenpiq solution.

When can you eat after a colonoscopy?

You can start eating regular foods the next day. Keep eating light meals if you are not able to pass gas and still feel bloated. For the first 24 hours after your procedure: Do not drink alcohol.

What is the recommended dosage for Powder for Oral Solution?

The recommended dosage of Powder for Oral Solution will depend on the specific treatment and the patient’s age. Generally, it is recommended to follow the dosage instructions that are provided with the medication.

What should I do if I miss a dose of Powder for Oral Solution?

If you miss a dose of Powder for Oral Solution, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Resources

• https://medlineplus.gov/druginfo/meds/a613020.html
• https://my.clevelandclinic.org/health/drugs/21319-sodium-picosulfate-magnesium-oxide-anhydrous-citric-acid-solution
• https://www.mayoclinic.org/drugs-supplements/sodium-picosulfate-magnesium-and-citric-acid-oral-route/precautions/drg-20075687
• https://www.webmd.com/drugs/2/drug-161661/sodium-picosulfate-magnesium-oxide-citric-acid-oral/details
• https://www.ferring.com/fda-approves-ferrings-clenpiq-sodium-picosulfate-magnesium-oxide-and-anhydrous-citric-acid-oral-solution-for-colonoscopy-prep/