Indications
CeeNU (generically known as Lomustine Capsules) is a cancer medication used to treat brain tumors and Hodgkin's disease. Lomustine belongs to a class of drugs known as alkylating agents. It works by slowing or stopping the growth of cancer cells by interfering with the DNA within the cells.
The dosage adjustment of CeeNU must be considered based on nadir blood counts from prior doses as the bone marrow toxicity of CeeNU is cumulative. The drug is potent and should be used only by physicians experienced with cancer chemotherapeutic drugs.
Use and Dosage
CeeNU is available in capsule form to be taken orally as a single dose by following your doctor's instructions, usually once every 6 weeks. Swallow the capsules whole, don’t chaw, crush it down. Your dose may consist of capsules of 2 or more different strengths/colors. Take the medication on an empty stomach at least 1 hour before or 2 to 3 hours after a meal, with a full glass of water unless directed otherwise by your doctor, to avoid nausea and vomiting.
The dosage of CeeNU is based on numerous factors including your medical condition, response to treatment, body size, and lab tests. Do not increase your dose or use CeeNU more often or for longer than prescribed, as it may increase the risk of side effects and will not improve your condition any faster.
Make sure to wear rubber or latex gloves while handling the capsules, as CeeNU capsules can be absorbed through the skin and lungs. Pregnant women or women who may become pregnant should avoid handling CeeNU or breathing the dust from the capsules, as it may harm the unborn baby.
Side Effects
Common Side Effects of CeeNU (Lomustine):
- Diarrhea
- Loss of appetite
- Mouth/lip sores
- Nausea/vomiting (may be severe
- Temporary hair loss
- Vision problems
- Weakness or tiredness
Serious Side Effects of CeeNU (Lomustine):
- Blisters or ulcers in your mouth
- Chest pain
- Chills
- Difficulty breathing
- Easy bruising
- Fever
- Hives
- Little or no urination
- New or worsening cough
- Purple or red pinpoint sports under the skin
- Red or swollen gums
- Shortness of breath (may develop as long as 6 months or later after taking the medication)
- Sore throat
- Swelling in your feet or ankles
- Swelling of your face lips, tongue, or throat
- Tiredness
- Trouble swallowing
- Unusual bleeding (nose mouth vagina or rectum)
- Yellowing of the skin or eyes (jaundice)
- Serious eye symptoms such as: sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights
- Serious heart symptoms such as: fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheadedness, or passing out
- Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors
Forms and Strength
CeeNU (Lomustine) is available in the following forms and strength:
CeeNU: Capsule
- 10 mg
- 40 mg
Cautions
- CeeNU should not be used during pregnancy as it can harm the unborn baby.
- CeeNU may cause a decrease in bone marrow function leading to anemia, bleeding, and increased risk of infection.
- CeeNU may cause liver damage or liver failure. Patients should have regular liver function tests while taking this medication.
- CeeNU may cause lung damage or lung fibrosis. Symptoms of lung damage include coughing or difficulty breathing.
- CeeNU may increase the risk of developing secondary cancers.
- Patients should not receive live vaccines while taking CeeNU as it may reduce the effectiveness of the vaccine.
- CeeNU may cause kidney damage or kidney failure. Patients should have regular kidney function tests while taking this medication.
- CeeNU may cause seizures. Patients with a history of seizures should be closely monitored while taking this medication.
- Patients with impaired lung function may be at increased risk of lung toxicity while taking CeeNU.
- CeeNU may cause gastrointestinal side effects such as nausea, vomiting, and diarrhea.
- Patients with a history of liver or kidney disease may be at increased risk of liver or kidney toxicity while taking CeeNU.
- Since CeeNU may decrease bone marrow function, patients with a history of bone marrow suppression or blood disorders should be closely monitored.
Frequently Asked Questions (FAQ)
How should patients take CeeNU?
Patients should take CeeNU exactly as directed by their healthcare provider. The dose and frequency of administration may vary depending on the patient's condition and other factors.
What should patients do if they miss a dose of CeeNU?
Patients should contact their healthcare provider if they miss a dose of CeeNU. Do not take a double dose to make up for a missed dose.
How long do the effects of CeeNU last?
The effects of CeeNU can vary depending on the patient's condition and other factors. Patients should consult with their healthcare provider for more information.
Can CeeNU be used to treat other types of cancer besides brain tumors and Hodgkin's lymphoma?
CeeNU may be used to treat other types of cancer, but this should be determined by a healthcare provider based on the patient's condition and other factors.
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