Kidney Problems
Boniva Injection is removed from the body through the kidneys.
It should be used carefully in people with reduced kidney function. Your healthcare provider may check your kidney function before each dose.
Boniva Injection is generally not recommended in people with severe kidney impairment.
Low Calcium Levels
Boniva can lower calcium levels in the blood.
Any low calcium level should be corrected before treatment begins. Your healthcare provider may also recommend calcium and vitamin D supplements.
Tell your healthcare provider if you develop muscle cramps, tingling, numbness, or muscle spasms.
Dental Problems and Jaw Bone Damage
Bisphosphonates such as Boniva have been linked to a rare condition called osteonecrosis of the jaw.
The risk may be higher in people who:
- Need major dental procedures
- Have poor oral health
- Have cancer
- Use corticosteroids
- Receive certain cancer treatments
Tell your healthcare provider and dentist that you receive Boniva before having dental work.
Unusual Thigh Bone Fractures
Rarely, long-term bisphosphonate treatment can cause unusual fractures of the thigh bone.
Tell your healthcare provider if you develop new or unexplained pain in your thigh, hip, or groin.
Severe Bone, Joint, or Muscle Pain
Boniva can sometimes cause severe bone, joint, or muscle pain.
Symptoms may begin within days or may occur months after starting treatment.
Contact your healthcare provider if you develop severe or persistent pain.
Pregnancy and Breastfeeding
Boniva Injection is intended for postmenopausal women.
Tell your healthcare provider if you are pregnant, may become pregnant, or are breastfeeding. Boniva is generally not used during pregnancy.
Allergic Reactions
Do not use Boniva Injection if you are allergic to ibandronate or any ingredient in the medication.
Seek emergency medical attention if you develop swelling of the face, lips, tongue, or throat, severe rash, or trouble breathing.
Other Medications and Supplements
Tell your healthcare provider about all prescription medications, over-the-counter products, vitamins, and supplements you take.
Extra care may be needed with medications that can also affect the kidneys or calcium levels.
Regular Monitoring
Your healthcare provider may periodically review your kidney function, calcium and vitamin D levels, dental health, and overall fracture risk.
Long-term bisphosphonate treatment should be reviewed regularly to make sure the benefits continue to outweigh the risks.
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