Allergic Reactions and Angioedema
Do not take Aceon if you are allergic to perindopril or another ACE inhibitor.
Aceon can rarely cause angioedema, a serious allergic-type reaction that may cause swelling of the:
Seek emergency medical attention if you develop swelling or have trouble breathing or swallowing.
Pregnancy
Do not use Aceon during pregnancy.
ACE inhibitors such as perindopril can cause serious harm or death to a developing baby, especially later in pregnancy.
If you become pregnant while taking Aceon, contact your healthcare provider right away. Aceon should generally be stopped as soon as pregnancy is detected.
Breastfeeding
Tell your healthcare provider if you are breastfeeding.
It is not known whether perindopril passes into human breast milk. Your healthcare provider will consider the benefits of treatment and the possible risks to your baby before deciding whether Aceon is appropriate.
Low Blood Pressure and Dizziness
Aceon can lower your blood pressure too much, especially when you first start treatment or after your dose is increased.
You may experience:
- Dizziness
- Lightheadedness
- Weakness
- Fainting
Stand up slowly from a sitting or lying position.
The risk may be higher if you are dehydrated, taking a diuretic, or losing fluids from vomiting or diarrhea.
Kidney Problems
Aceon can affect kidney function.
Tell your healthcare provider if you already have kidney disease or take medications that can affect your kidneys.
Your healthcare provider may check your kidney function before and during treatment.
High Potassium Levels
Aceon can increase the amount of potassium in your blood.
The risk is higher if you:
- Have kidney problems
- Have diabetes
- Take potassium supplements
- Use potassium-containing salt substitutes
- Take potassium-sparing diuretics
Your healthcare provider may check your potassium level with blood tests.
Persistent Dry Cough
ACE inhibitors such as Aceon can cause a persistent dry cough.
The cough usually improves after the medication is stopped, although it may take some time to completely disappear.
Tell your healthcare provider if you develop a cough that becomes bothersome or does not go away.
Drug Interactions
Tell your healthcare provider about all prescription medications, over-the-counter products, vitamins, and supplements you take.
Aceon may interact with:
- Diuretics
- Potassium supplements
- Potassium-sparing diuretics
- Potassium-containing salt substitutes
- NSAIDs such as ibuprofen or naproxen
- Lithium
- Aliskiren
- Other medications that affect the renin-angiotensin system
Some combinations can increase the risk of low blood pressure, kidney problems, or high potassium levels.
NSAIDs
Regular use of NSAIDs such as ibuprofen or naproxen may reduce the blood-pressure-lowering effect of Aceon.
They may also increase the risk of kidney problems, particularly in older adults, people who are dehydrated, or people who already have kidney impairment.
Liver Problems
Rarely, ACE inhibitors have been associated with serious liver problems.
Contact your healthcare provider right away if you develop:
- Yellowing of the skin or eyes
- Dark urine
- Severe abdominal pain
- Unusual tiredness
These may be signs of a liver problem.
Driving and Operating Machinery
Aceon may cause dizziness or lightheadedness.
Avoid driving, operating machinery, or performing other activities that require alertness until you know how the medication affects you.
Heart, Kidney, Liver, or Diabetes History
Tell your healthcare provider if you have heart disease, kidney problems, liver problems, diabetes, or another serious medical condition.
These conditions do not always prevent you from taking Aceon, but you may need a lower dose or closer monitoring.
Take Aceon Exactly as Prescribed
Take Aceon exactly as directed by your healthcare provider.
Do not take extra doses if you miss one, and do not change or stop your treatment without medical advice.
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