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Zyloprim (active ingredient: allopurinol) is a prescription medication used to lower high uric acid levels in the body. It is commonly prescribed for the long-term prevention of gout attacks and for managing high uric acid levels caused by certain medical conditions or cancer treatments.
Uric acid is a waste product created when the body breaks down substances called purines. Purines are found naturally in the body and in certain foods. The kidneys normally remove uric acid through the urine. However, uric acid can build up when the body produces too much or when the kidneys cannot remove enough.
Zyloprim reduces the amount of uric acid the body produces. This helps prevent uric acid crystals from forming in the joints, kidneys, and other tissues.
Gout is a form of inflammatory arthritis caused by a buildup of uric acid crystals inside a joint. It often affects the big toe, but it may also occur in the ankles, knees, wrists, fingers, or elbows.
A gout attack may cause:
Gout attacks may begin suddenly and can last for several days. Without proper treatment, attacks may become more frequent and cause lasting joint damage.
Zyloprim is mainly used to prevent future gout attacks. It gradually lowers uric acid levels, reducing the likelihood that new crystals will form.
Over time, treatment may:
Tophi are firm lumps of uric acid crystals that may form under the skin around the fingers, toes, elbows, ears, or other joints after long-term uncontrolled gout.
Zyloprim does not provide immediate relief from the pain and inflammation of an active gout attack. Other medications, such as anti-inflammatory treatments, may be prescribed to manage sudden symptoms.
Gout attacks may temporarily become more frequent when Zyloprim is first started because changing uric acid levels can disturb existing crystals. A healthcare provider may prescribe another medication during the first few months to help prevent these early attacks.
Do not stop taking Zyloprim during a gout attack unless a healthcare provider tells you to do so. Stopping and restarting the medication may cause uric acid levels to fluctuate and increase the risk of further attacks.
Hyperuricaemia means that the level of uric acid in the blood is higher than normal. It does not always cause symptoms, but persistently high levels can increase the risk of gout, kidney stones, and kidney damage.
High uric acid levels may develop because of:
Zyloprim is not usually prescribed for every person with an elevated uric acid level. A healthcare provider will consider the cause, symptoms, medical history, and risk of complications before recommending treatment.
Some cancer treatments destroy large numbers of cancer cells quickly. When these cells break down, they release substances that the body converts into uric acid.
A sudden rise in uric acid may occur as part of a condition called tumour lysis syndrome. This can lead to crystals forming in the kidneys and may cause serious kidney damage.
Zyloprim may be given before or during chemotherapy to reduce uric acid production. This helps lower the risk of complications while the body processes the substances released from damaged cancer cells.
High uric acid levels can contribute to the development of certain kidney stones. Zyloprim may be prescribed when a person repeatedly develops uric acid stones or certain calcium-containing stones linked to excess uric acid.
By reducing uric acid production, Zyloprim may help prevent new stones from forming. Drinking enough fluids may also support kidney function and reduce stone formation unless a healthcare provider has advised fluid restriction.
Zyloprim belongs to a class of medications called xanthine oxidase inhibitors.
Xanthine oxidase is an enzyme that helps convert purines into uric acid. Zyloprim blocks this enzyme, which decreases the amount of uric acid produced by the body.
As uric acid levels fall:
The full benefits develop gradually and may take several weeks or months.
The correct dose of Zyloprim varies from person to person. A healthcare provider may consider:
Treatment usually begins with a low dose. The dose may then be increased gradually until the uric acid level reaches the desired range.
People with reduced kidney function may require a lower dose or slower dose adjustments.
A healthcare provider may order blood tests before and during treatment. These tests may monitor:
Regular monitoring helps determine whether the dose is effective and whether Zyloprim is being tolerated safely.
Zyloprim is often used as a long-term medication. It controls uric acid levels while it is being taken, but it does not permanently cure the underlying cause of gout.
Continue taking Zyloprim exactly as directed, even when you feel well or have not experienced a recent gout attack. Uric acid levels may rise again if treatment is stopped.
Do not change the dose or stop taking Zyloprim without speaking with a healthcare provider.
Zyloprim may be used as part of a broader uric acid management plan. This may include:
Medication and lifestyle measures can work together to reduce gout attacks, protect the joints and kidneys, and maintain healthier uric acid levels.
Take Zyloprim exactly as prescribed by your healthcare provider. The medication is taken by mouth and may be prescribed once daily or in several divided doses.
Zyloprim is generally better tolerated when taken after a meal. Taking it with food may help reduce nausea, stomach discomfort, or digestive upset.
Swallow each tablet with water. Try to take the medication at approximately the same time each day to help maintain consistent uric acid control.
Drink enough fluids while taking Zyloprim unless your healthcare provider has told you to limit your fluid intake.
Adequate hydration helps the kidneys remove uric acid and may reduce the risk of kidney stones. The prescribing information generally recommends enough fluid to produce at least 2 litres of urine per day in adults, but the appropriate fluid intake depends on your health and kidney or heart function.
Daily doses of 300 mg or less may usually be taken as a single dose. If the prescribed daily dose is more than 300 mg, it should generally be divided into two or more smaller doses.
Dividing larger doses may improve tolerability and reduce stomach-related side effects. Follow the exact schedule provided by your healthcare provider.
For adults with normal kidney function, the usual starting dose for gout is 100 mg once daily.
Starting with a low dose and increasing it gradually can reduce the risk of gout flares and serious medication reactions. A healthcare provider may increase the dose by 100 mg each week until the blood uric acid level reaches 6 mg/dL or lower.
People with kidney impairment may begin with a lower dose, such as 50 mg daily or less frequently, depending on kidney function. Dose increases are generally smaller and made more slowly in these patients.
The maintenance dose depends on the severity of gout and the response to treatment.
People with mild gout may require approximately 200 mg to 300 mg per day. People with moderate to severe tophaceous gout may require approximately 400 mg to 600 mg per day.
The maximum recommended dose is 800 mg per day. The goal is to use the lowest dose that keeps the uric acid level within the target range and prevents gout complications.
Gout attacks may temporarily become more frequent when Zyloprim is first started. This happens because changing uric acid levels can disturb crystals that are already present in the joints.
A healthcare provider may prescribe colchicine or another anti-inflammatory medication during the first few months of treatment to help prevent these attacks.
Do not stop taking Zyloprim if a gout attack occurs unless your healthcare provider tells you to stop. The gout attack can usually be treated while you continue taking Zyloprim.
For adults with high uric acid caused by cancer therapy, the recommended dose may range from 300 mg to 800 mg per day.
Treatment is generally started 24 to 48 hours before chemotherapy that is expected to cause rapid tumour cell breakdown. The medication is usually continued until the risk of tumour lysis has passed and uric acid levels are controlled.
Blood uric acid and kidney function may be monitored closely, often at least daily during the period of highest risk. Fluid intake is also carefully managed by the cancer care team.
The earlier statement that treatment always lasts only two or three days is too restrictive. The prescribing information says treatment may be stopped when the tumour-lysis risk has passed, which is often two to three days after chemotherapy begins, but the exact duration must be individualised.
For children with cancer treatment-related high uric acid, the recommended dose is generally based on body surface area or body weight.
A labelled regimen is 100 mg per square metre of body surface area every 8 to 12 hours, or approximately 10 mg per kilogram per day. The maximum total dose is 800 mg per day.
A paediatric cancer specialist must calculate and monitor the dose.
For adults with recurrent calcium oxalate kidney stones associated with excessive uric acid in the urine, the recommended dose is generally 200 mg to 300 mg per day.
The dose may be taken once daily or divided into smaller doses. A healthcare provider may adjust it based on 24-hour urine uric acid test results and the response to treatment.
Zyloprim is not prescribed for every type of kidney stone. It is used for certain recurrent calcium oxalate stones associated with high urinary uric acid despite appropriate lifestyle measures.
Zyloprim and its active breakdown product are removed mainly through the kidneys. Reduced kidney function can cause the medication to accumulate in the body and increase the risk of serious side effects.
A healthcare provider may prescribe a lower starting dose, increase it more slowly, or extend the time between doses. Kidney function should be monitored during treatment, particularly when Zyloprim is first started.
Do not use another person’s dose or adjust your own dose based only on general dosing information.
Before and during treatment, a healthcare provider may check:
These results help determine whether the dose is effective and safe.
Take a missed dose as soon as you remember. However, skip it if it is almost time for your next scheduled dose.
Continue with your regular schedule. Do not take two doses at the same time or take extra tablets to replace the missed dose.
Zyloprim is often taken for a long time to keep uric acid levels controlled. It does not provide immediate pain relief during a gout attack.
Continue taking the medication even if you feel well or have not recently experienced gout symptoms. Stopping treatment may allow uric acid levels to rise again.
Do not change the dose or stop taking Zyloprim without first speaking with a healthcare provider.
Zyloprim (Allopurinol) is available in the following forms and strength:
Zyloprim may cause a rare but serious hypersensitivity reaction. Stop taking the medication and seek immediate medical attention if you develop a rash or other signs of an allergic reaction.
Possible warning signs include:
A serious reaction may affect the skin, liver, kidneys, blood cells, or other organs. Do not restart Zyloprim after a serious hypersensitivity reaction unless a specialist specifically advises you to do so.
Zyloprim may rarely cause life-threatening skin reactions, including Stevens–Johnson syndrome and toxic epidermal necrolysis.
Stop taking Zyloprim and seek urgent medical care at the first sign of:
Do not wait for the rash to become severe before seeking medical help.
People who carry a genetic marker called HLA-B*58:01 have a higher risk of severe allopurinol-related skin reactions.
This marker occurs more frequently in certain populations, including people of Han Chinese, Korean, Thai, or some African ancestry. A healthcare provider may recommend genetic testing before treatment when the risk is considered high.
Genetic testing does not replace careful monitoring. Anyone taking Zyloprim should seek medical care immediately if a rash develops.
Zyloprim and its active breakdown product are removed mainly through the kidneys. People with reduced kidney function may require a lower starting dose, slower dose increases, or more time between doses.
Tell your healthcare provider if you have kidney disease, receive dialysis, have a history of kidney stones, or take medications that affect kidney function.
Kidney function may be monitored before and during treatment.
Zyloprim may cause liver injury in some people. Tell your healthcare provider if you have a history of liver disease.
Your healthcare provider may order liver function tests before or during treatment. Contact them promptly if you develop dark urine, severe nausea, unusual tiredness, upper abdominal pain, or yellowing of the skin or eyes.
Zyloprim can interact with several medications. Tell your healthcare provider about all prescription medications, nonprescription products, vitamins, and supplements you use.
Important interactions may occur with:
The doses of some medications may need to be reduced, and additional blood tests may be required.
Tell your healthcare provider if you are pregnant, planning to become pregnant, or think you may be pregnant.
Available human information is limited, and animal studies have identified possible risks. A healthcare provider will consider the need for treatment and the potential risks before recommending Zyloprim during pregnancy.
Allopurinol and its active metabolite can pass into breast milk. Speak with a healthcare provider before breastfeeding during treatment.
A healthcare provider may recommend monitoring the nursing infant for symptoms such as a rash or unusual reactions when treatment is considered necessary.
Tell your healthcare provider about all existing medical conditions before starting Zyloprim. This is especially important if you have kidney disease, liver disease, blood disorders, or a history of severe medication allergies.
Diabetes or high blood pressure do not automatically prevent someone from using Zyloprim. However, the medications used to treat these conditions may interact with Zyloprim or affect kidney function.
Tell your surgeon, dentist, or healthcare team that you take Zyloprim before a planned procedure.
Zyloprim is not generally known to directly interfere with anaesthesia, but your healthcare team should review all medications before surgery. Do not stop taking it unless you are specifically instructed to do so.
Take the missed dose as soon as you remember. However, skip it if it is almost time for your next scheduled dose. Continue with your regular dosing schedule. Do not take two doses at the same time or take extra medication to replace the missed dose.
No. Zyloprim does not cure gout or provide immediate relief from an active gout attack. It lowers uric acid levels over time, which helps prevent new crystals from forming in the joints. Regular treatment may reduce the frequency of gout attacks, help existing uric acid deposits gradually dissolve, and prevent joint damage.
Zyloprim can interact with certain medications, including some blood thinners, diuretics, immune-suppressing medicines, and cancer treatments. Tell your healthcare provider about all prescription medications, nonprescription products, vitamins, and supplements you use. Some doses may need to be adjusted, and additional monitoring may be required.
Zyloprim begins reducing uric acid production after treatment starts, but it may take several weeks to reach the target uric acid level. The full benefits, such as fewer gout attacks or smaller uric acid deposits, may take several months. Gout attacks may temporarily become more frequent when treatment first begins. Continue taking Zyloprim as prescribed unless your healthcare provider tells you to stop.
| Generic name: | Allopurinol |
|---|---|
| Formulation: | Tablet |
| Strength(s): | 100mg, 300mg |
| Quantities Available: | 84, 100 |
Our online Canadian Pharmacy is known for high standards of quality, safety, and efficiency when it comes to medications.
Our pharmacy offers lower prices on prescription drugs compared to traditional pharmacies.
When ordering Zyloprim (allopurinol) from a Canadian pharmacy, you can typically purchase up to a 90-day supply at one time, which is standard for prescription medications to ensure continuous management of conditions like gout without frequent refills.
Here’s what you need to know:
Dosage and Quantity: Zyloprim is commonly prescribed in dosages of 200 mg or 300 mg tablets, usually taken once daily. For a 90-day supply, this means you would order 90 tablets (90 days x 1 tablet per day).
Yes, we sell allopurinol on our website. You can enjoy low prices when you order through us. To purchase allopurinol, you will need a valid prescription from your healthcare provider, as we require this to dispense the medication safely and appropriately. You have the option to submit your prescription by mailing it to us, faxing it, or uploading it securely through your online account.
Yes, we ship Zyloprim (allopurinol) to both the United States and Puerto Rico.
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Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Zyloprim (Allopurinol). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Zyloprim (Allopurinol).
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