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Prescription Prescription Required FormationFormulation: Sublingual Tablet

Saphris

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Prescription Prescription Required FormationFormulation: Sublingual Tablet

Asenapine

(Generic Alternative)

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Saphris contains the active ingredient asenapine. It is a prescription medication used to treat schizophrenia and certain symptoms of bipolar I disorder.

Schizophrenia

Saphris is used to treat schizophrenia in adults and adolescents 13 to 17 years of age.

Schizophrenia is a mental health condition that can affect thinking, emotions, behavior, and how a person understands reality.

Symptoms may include:

  • Hallucinations
  • Delusions
  • Disorganized thinking or speech
  • Difficulty concentrating
  • Reduced motivation
  • Social withdrawal

Saphris may help reduce psychotic symptoms and improve overall functioning in some patients.

Bipolar I Disorder

Saphris is also used to treat acute manic or mixed episodes associated with bipolar I disorder in adults and adolescents 10 to 17 years of age.

A manic episode may involve:

  • Very high or irritable mood
  • Increased energy
  • Reduced need for sleep
  • Rapid speech
  • Racing thoughts
  • Impulsive or risky behavior

A mixed episode includes symptoms of mania together with symptoms of depression.

Saphris may help reduce these symptoms and stabilize mood.

How Saphris Works

Saphris belongs to a class of medications called atypical antipsychotics.

Its exact mechanism is not completely understood, but it affects several chemical messengers in the brain, especially dopamine and serotonin.

By changing how these neurotransmitters act at certain receptors, Saphris may help reduce psychotic symptoms, control mania, and improve mood stability.

Role in Schizophrenia Treatment

For schizophrenia, Saphris may be used as part of a long-term treatment plan.

Treatment may also include:

  • Counseling or psychotherapy
  • Family support
  • Social and occupational support
  • Regular mental health follow-up
  • Other medications when needed

The goal is to reduce symptoms, prevent relapse, and support daily functioning.

Role in Bipolar Disorder Treatment

For bipolar I disorder, Saphris may be used to control acute manic or mixed symptoms.

Depending on the patient and treatment plan, it may sometimes be used alone or together with other mood-stabilizing medications.

A healthcare provider will determine the most appropriate treatment based on symptoms, medical history, response to previous medications, and side effects.

Regular Monitoring

Patients taking Saphris may need regular follow-up to monitor:

  • Mood and behavior
  • Weight
  • Blood sugar
  • Cholesterol and triglycerides
  • Movement-related side effects
  • Blood pressure
  • Sedation or dizziness

Do not stop Saphris or change your dose without speaking with your healthcare provider.

Saphris is a sublingual tablet, which means it is placed under the tongue and allowed to dissolve.

It is usually taken twice daily, exactly as prescribed by your healthcare provider.

How to Use the Sublingual Tablet

Use dry hands when handling Saphris.

Peel back the packaging to remove the tablet. Do not push the tablet through the foil.

Place the tablet under your tongue and allow it to dissolve completely.

Do not:

  • Chew the tablet
  • Crush or split it
  • Swallow it whole

After taking Saphris, do not eat or drink anything for 10 minutes. This helps your body absorb the medication properly.

Take Saphris Regularly

Take Saphris at about the same times each day.

Regular use is important because it may take several days or weeks before you notice the full benefit.

Do not take more Saphris or take it more often than prescribed. A higher dose will not make the medication work faster and may increase the risk of side effects.

Dose for Schizophrenia in Adults

For adults with schizophrenia, the usual dose is 5 mg under the tongue twice daily.

If needed, the dose may be increased to 10 mg twice daily.

The maximum recommended dose is generally 10 mg twice daily.

Dose for Schizophrenia in Adolescents

For adolescents 13 to 17 years of age, dosing is determined by the healthcare provider and may be increased gradually based on response and tolerability.

Dose for Bipolar I Disorder in Adults

For acute manic or mixed episodes associated with bipolar I disorder, the dose depends on whether Saphris is used alone or together with another medication.

Typical doses range from 5 mg to 10 mg under the tongue twice daily.

The maximum recommended dose is generally 10 mg twice daily.

Dose for Bipolar I Disorder in Children and Adolescents

For patients 10 to 17 years of age, treatment generally begins with a lower dose and is increased gradually.

A typical starting dose is 2.5 mg twice daily, which may be increased to 5 mg twice daily and then to 10 mg twice daily if needed and tolerated.

The maximum recommended dose is generally 10 mg twice daily.

Your Dose May Be Adjusted

Your healthcare provider may adjust your dose based on:

  • The condition being treated
  • Your age
  • How well your symptoms respond
  • Side effects
  • Other medications you take
  • Your overall medical condition

Tell your healthcare provider about all prescription medications, over-the-counter products, vitamins, supplements, and herbal products you use.

Do Not Stop Saphris Suddenly

Do not stop taking Saphris without speaking with your healthcare provider, even if you feel better.

Stopping treatment may cause symptoms of schizophrenia or bipolar disorder to return or worsen.

What to Do If You Miss a Dose

If you miss a dose of Saphris, take it when you remember unless it is almost time for your next scheduled dose.

If your next dose is due soon, skip the missed dose and continue with your regular schedule.

Do not take two doses at the same time or take extra Saphris to make up for a missed dose.

Common Effects of Saphris (Asenapine):

  • Altered sense of taste
  • Drowsiness
  • Feeling tired
  • Inability to sit still
  • Increased appetite
  • Nausea
  • Numbness or tingling inside or around your mouth
  • Restlessness
  • Ulcers
  • Blisters, swelling, or peeling of your gums
  • Weight gain

Serious Effects of Saphris (Asenapine):

  • Breast pain or swelling
  • Chills
  • Cold or flu symptoms
  • Confusion
  • Cough
  • Fast or uneven heartbeats
  • Fever
  • High fever
  • Ill feeling
  • Lightheadedness
  • Nipple discharge
  • Painful mouth sores
  • Skin sores
  • Slow heartbeats
  • Slurred speech
  • Sore throat
  • Sudden numbness or weakness
  • Sudden severe headache
  • Sudden weakness
  • Sweating
  • Swollen gums
  • Tremors
  • Trouble swallowing
  • Twitching
  • Uncontrollable movements of your eyes, lips, tongue, face, arms, or legs
  • Very stiff (rigid) muscles

Saphris (Asenapine) is available in the following forms and strength:

Saphris: Sublingual Tablet

  • 5 mg
  • 10 mg

Asenapine: Sublingual Tablet

  • 5 mg

Dementia-Related Psychosis

Saphris is not approved for the treatment of dementia-related psychosis.

Older adults with dementia-related psychosis who take antipsychotic medications have an increased risk of death and may also have a higher risk of stroke or other serious cardiovascular events.

Neuroleptic Malignant Syndrome

Saphris can rarely cause neuroleptic malignant syndrome (NMS), a serious reaction to antipsychotic medications.

Seek immediate medical attention if you develop symptoms such as:

  • High fever
  • Severe muscle stiffness
  • Confusion
  • Heavy sweating
  • Fast or irregular heartbeat
  • Changes in blood pressure

NMS is a medical emergency.

Tardive Dyskinesia

Long-term use of Saphris may cause tardive dyskinesia, a condition involving involuntary and sometimes persistent movements.

Symptoms may include:

  • Lip smacking
  • Tongue movements
  • Facial grimacing
  • Repetitive movements of the arms or legs

Contact your healthcare provider if you notice new or unusual movements.

Blood Sugar, Weight, and Cholesterol Changes

Saphris may cause metabolic changes, including:

  • Increased blood sugar
  • Weight gain
  • Increased cholesterol
  • Increased triglycerides

Your healthcare provider may monitor your weight, blood sugar, and lipid levels during treatment.

Tell your healthcare provider if you develop increased thirst, frequent urination, unusual hunger, or unexplained weight changes.

Heart Problems

Tell your healthcare provider if you have a history of:

  • Heart attack
  • Heart failure
  • Irregular heart rhythm
  • Low blood pressure
  • Fainting

Saphris may affect heart rhythm or blood pressure in some patients.

Dizziness and Fainting

Saphris may cause dizziness, lightheadedness, or fainting, especially when standing up quickly.

Rise slowly from sitting or lying positions and use caution until you know how the medication affects you.

Drowsiness and Reduced Alertness

Saphris may cause drowsiness or reduced alertness.

Avoid driving, operating machinery, or performing other activities that require concentration until you know how Saphris affects you.

Seizure Risk

Tell your healthcare provider if you have a history of seizures or a condition that increases seizure risk.

Saphris may lower the seizure threshold in some patients.

Drug Interactions

Saphris can interact with other medications.

Tell your healthcare provider about all prescription medications, over-the-counter products, vitamins, supplements, and herbal products you use.

Some medications may increase drowsiness, affect heart rhythm, or change the amount of Saphris in your body.

Do Not Stop Saphris on Your Own

Do not stop Saphris suddenly without speaking with your healthcare provider.

Stopping treatment may cause schizophrenia or bipolar symptoms to return or worsen. Some patients may also experience symptoms such as nausea, vomiting, insomnia, or agitation.

Your healthcare provider can help you stop treatment safely if needed.

Pregnancy

Tell your healthcare provider if you are pregnant, think you may be pregnant, or plan to become pregnant.

Using antipsychotic medications during the third trimester may cause movement-related or withdrawal symptoms in newborns.

Your healthcare provider will weigh the benefits of treatment against the potential risks during pregnancy.

Breastfeeding

Tell your healthcare provider if you are breastfeeding or plan to breastfeed.

It is not known with certainty how much asenapine passes into human breast milk. Your healthcare provider can help determine whether Saphris or breastfeeding is appropriate based on the potential benefits and risks.

Regular Monitoring

Your healthcare provider may monitor:

  • Weight
  • Blood sugar
  • Cholesterol and triglycerides
  • Blood pressure
  • Heart rhythm
  • Movement-related side effects
  • Mood and behavior

Regular follow-up helps make sure Saphris remains safe and effective.

What should I do if I miss a dose of Saphris?

If you miss a dose of Saphris, take it as soon as you remember unless it is almost time for your next scheduled dose. If your next dose is due soon, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time or take extra Saphris to make up for a missed dose.

Can Saphris be taken during pregnancy?

Saphris may be used during pregnancy when a healthcare provider determines that the potential benefits outweigh the possible risks. Tell your healthcare provider if you are pregnant, think you may be pregnant, or plan to become pregnant. Taking antipsychotic medications during the third trimester may cause movement-related or withdrawal symptoms in newborns, so treatment should be monitored carefully. Do not stop Saphris on your own if you become pregnant.

How long does Saphris take to dissolve?

Saphris is a sublingual tablet that is placed under the tongue and allowed to dissolve completely. The tablet usually dissolves quickly, often within seconds. Do not chew, crush, split, or swallow it whole. After the tablet dissolves, avoid eating or drinking for 10 minutes so the medication can be absorbed properly.

How long does Saphris take to work?

Some symptoms may begin to improve within the first 1 to 2 weeks of treatment, but the full benefit can take several weeks. Improvements in mood, thinking, sleep, agitation, or other symptoms may occur gradually. Some people may continue to improve over the first few months of treatment. Continue taking Saphris exactly as prescribed, even if you do not notice an immediate change. Contact your healthcare provider if your symptoms do not improve or become worse.

REVIEWS

Additional Information Book
Generic name:

Asenapine

Formulation:

Sublingual Tablet, Sublingual Tablets

Strength(s):

5mg, 10mg

Quantities Available:

60, 90, 120, 180

Why customers love Online Pharmacies Canada

Our online Canadian Pharmacy is known for high standards of quality, safety, and efficiency when it comes to medications.

Our pharmacy offers lower prices on prescription drugs compared to traditional pharmacies.

How to Order

How much Saphris can I order at once from a Canadian pharmacy?

When ordering Saphris (asenapine) from a Canadian pharmacy, you can typically purchase up to a 90-day supply at one time, which is common for prescription medications to ensure adequate management of chronic conditions without frequent refills.

Here’s what you need to know:

Dosage and Quantity: Saphris is commonly prescribed in dosages of 5 mg or 10 mg, typically taken twice daily. For a 90-day supply, this means you would order 180 tablets (90 days x 2 tablets per day).

Do you sell asenapine?

Yes, we sell asenapine on our website. You can enjoy low prices when you order through us. To purchase asenapine, you will need a valid prescription from your healthcare provider. We require this prescription to dispense the medication safely and appropriately. You have the option to submit your prescription by mailing it to us, faxing it, or uploading it through your online account.

Do you offer shipping of Saphris (asenapine) to the United States?

Yes, we ship Saphris (asenapine) to both the United States and Puerto Rico.

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Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Saphris (Asenapine). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Saphris (Asenapine).