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Prescription Prescription Required FormationFormulation: Film Coated Tablet

Motegrity

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Prescription Prescription Required FormationFormulation: Film Coated Tablet

Prucalopride Succinate

(Generic Alternative)

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Motegrity (active ingredient: prucalopride) is a prescription medication used to treat chronic idiopathic constipation (CIC) in adults.

Chronic idiopathic constipation is a condition in which a person experiences ongoing constipation without a known underlying cause. Common symptoms may include infrequent bowel movements, hard stools, straining during bowel movements, bloating, and a feeling of incomplete bowel emptying.

Motegrity belongs to a group of medications called serotonin-4 (5-HT4) receptor agonists. It works by stimulating the natural movement of the muscles in the digestive tract, helping food and waste move through the intestines more effectively.

Treatment of Chronic Idiopathic Constipation (CIC)

Motegrity is indicated for adults with chronic idiopathic constipation who need additional help improving bowel function.

The medication can help relieve symptoms such as:

  • Infrequent bowel movements
  • Difficulty passing stools
  • Straining during bowel movements
  • Hard or dry stools
  • A feeling of incomplete bowel emptying
  • Abdominal discomfort and bloating associated with constipation

How Motegrity Helps

  • Increases the frequency of bowel movements
  • Helps stools move through the intestines more efficiently
  • Reduces straining during bowel movements
  • Improves overall bowel function
  • May help relieve constipation-related discomfort

How Motegrity Works

Motegrity contains prucalopride, which activates serotonin-4 (5-HT4) receptors in the digestive tract.

These receptors help stimulate the muscles of the intestines, encouraging coordinated contractions that move stool through the colon. By improving intestinal motility, Motegrity helps promote more regular bowel movements and reduce symptoms of chronic constipation.

Because Motegrity works on the natural movement of the digestive system, it may help restore more regular bowel habits and improve overall digestive comfort when taken as prescribed.

Regular use, along with healthy lifestyle habits such as adequate fluid intake, a fiber-rich diet, and regular physical activity, may help maximize the benefits of treatment.

Motegrity is available as an oral tablet and should be taken exactly as prescribed by your healthcare provider. The medication may be taken with or without food and is typically taken once daily.

For the best results, take Motegrity at approximately the same time each day. Taking the medication consistently can help improve bowel regularity and provide more effective symptom relief.

Your prescribed dose may depend on factors such as your age, kidney function, medical history, and how well you respond to treatment. Always follow the instructions provided by your healthcare provider and do not change your dose unless directed to do so.

Recommended Dosage

Chronic Idiopathic Constipation (CIC)

For most adults, the typical recommended dose is:

  • 2 mg by mouth once daily

Patients with Severe Kidney Disease

If you have severe kidney impairment, your healthcare provider may recommend a lower dose:

  • 1 mg by mouth once daily

Your healthcare provider will determine the most appropriate dose based on your individual health needs.

Important Dosing Information

  • Take Motegrity exactly as prescribed.
  • Take the medication once daily.
  • It may be taken with or without food.
  • Take it at the same time each day whenever possible.
  • Do not take more or less than prescribed.
  • Continue taking the medication unless instructed otherwise by your healthcare provider.

Because chronic constipation can take time to improve, continue taking Motegrity as directed, even if you do not notice immediate results. Your healthcare provider may monitor your response to treatment and make adjustments if needed.

For best results, Motegrity should be used alongside healthy lifestyle habits, including adequate fluid intake, regular physical activity, and a balanced diet that supports digestive health.

Common Side Effects of Motegrity (Prucalopride Succinate):

  • Diarrhea
  • Dizziness
  • Fatigue
  • Gas
  • Headache
  • Nausea
  • Stomach area (abdominal) pain or bloating
  • Vomiting

Serious Side Effects of Motegrity (Prucalopride Succinate):

  • Unusual changes in mood or behavior
  • Thoughts of hurting yourself
  • Trying to hurt yourself
  • You feel sad
  • Hopeless or begin to have thoughts of suicide

Motegrity (Prucalopride Succinate) is available in the following forms and strengths:

Motegrity: Film-Coated Tablet

  • 1 mg
  • 2 mg

Prucalopride Succinate: Film-Coated Tablet

  • 2 mg

Before taking Motegrity, tell your healthcare provider about your complete medical history, especially if you have or have ever had:

  • Depression
  • Suicidal thoughts or behaviors
  • Other mood or mental health conditions
  • Kidney disease
  • Digestive tract disorders

Your healthcare provider will use this information to determine whether Motegrity is appropriate for you and whether additional monitoring is needed during treatment.

Mental Health Considerations

Some people taking Motegrity have reported changes in mood, including depression and suicidal thoughts. Although these events are uncommon, it is important to monitor for any changes in mood, behavior, or emotional well-being while taking this medication.

Contact your healthcare provider immediately if you experience:

  • New or worsening depression
  • Unusual mood changes
  • Thoughts of self-harm or suicide
  • Significant changes in behavior

Kidney Problems

If you have kidney disease or reduced kidney function, your healthcare provider may recommend a lower dose of Motegrity. Be sure to inform your healthcare provider about any kidney-related conditions before starting treatment.

Conditions Where Motegrity Should Not Be Used

Do not take Motegrity if you have:

  • A tear in the stomach or intestinal wall (bowel perforation)
  • A blockage in the intestines (intestinal obstruction)
  • Certain serious inflammatory bowel conditions affecting the intestinal wall

Tell your healthcare provider if you have digestive conditions such as Crohn’s disease or ulcerative colitis, as Motegrity may not be appropriate in some situations.

Pregnancy and Breastfeeding

If you are pregnant, planning to become pregnant, or think you may be pregnant, discuss this with your healthcare provider before taking Motegrity.

The safety of Motegrity during pregnancy has not been fully established. The medication should only be used during pregnancy when clearly needed and when the potential benefits outweigh the potential risks.

If you are breastfeeding or planning to breastfeed, speak with your healthcare provider about the risks and benefits of treatment.

Allergic Reactions

Do not take Motegrity if you are allergic to prucalopride or any of the ingredients in the medication.

Seek immediate medical attention if you develop signs of a serious allergic reaction, including:

  • Difficulty breathing
  • Rash or hives
  • Itching
  • Swelling of the face, lips, tongue, or throat

Dizziness and Activities Requiring Alertness

Motegrity may cause dizziness in some people, especially when first starting treatment.

Until you know how the medication affects you, avoid:

  • Driving
  • Operating machinery
  • Activities that require alertness or quick reactions

Alcohol and marijuana (cannabis) may increase dizziness and other side effects. Limit alcohol consumption and discuss marijuana use with your healthcare provider before taking Motegrity.

Regular follow-up appointments can help your healthcare provider monitor your response to treatment and ensure that Motegrity remains safe and effective for your condition.

How Long Does It Take for Motegrity to Work?

Motegrity does not work as quickly as some stimulant laxatives and is not intended to be taken on an as-needed basis. Instead, it is designed for regular daily use to help improve bowel function over time. Many people experience their first bowel movement within 1 to 5 days after starting treatment, although individual results can vary. Continue taking Motegrity exactly as prescribed, even if you do not notice immediate improvement.

Is Motegrity Safe to Take During Pregnancy?

There is currently limited information about the safety of Motegrity during pregnancy. If you are pregnant, planning to become pregnant, or think you may be pregnant, discuss this with your healthcare provider before starting treatment. A pregnancy registry is available to collect information about pregnancy outcomes in women who are exposed to Motegrity during pregnancy. Your healthcare provider can provide additional information if needed.

How Should I Take Motegrity?

Motegrity is taken by mouth and may be taken with or without food. The typical adult dose for chronic idiopathic constipation is 2 mg once daily, although your healthcare provider may adjust your dose based on factors such as kidney function, medical history, and response to treatment. Take the medication exactly as prescribed and at approximately the same time each day for the best results.

What Should I Do If I Miss a Dose?

If you miss a dose of Motegrity, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take two doses at the same time or take extra medication to make up for a missed dose.

Can I Take Motegrity While Breastfeeding?

If you are breastfeeding or planning to breastfeed, talk to your healthcare provider before taking Motegrity. It is not fully known how Motegrity may affect a nursing infant. Your healthcare provider can help you weigh the potential benefits and risks of treatment and determine whether Motegrity is appropriate for your situation.

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Additional Information Book
Generic name:

Prucalopride Succinate
Formulation:

Film Coated Tablet, Tablet
Strength(s):

1mg, 2mg
Quantities Available:

28, 56, 84, 100

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Our online Canadian Pharmacy is known for high standards of quality, safety, and efficiency when it comes to medications.

Our pharmacy offers lower prices on prescription drugs compared to traditional pharmacies.

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How to Order

How much Motegrity can I order at once from a Canadian pharmacy?

When ordering Motegrity (prucalopride) from a Canadian pharmacy, you can typically purchase up to a 90-day supply at one time, which is common for prescription medications to ensure adequate management of chronic conditions without frequent refills.

Here’s what you need to know:

Dosage and Quantity: Motegrity is commonly prescribed in dosages of 1 mg or 2 mg, taken once daily. For a 90-day supply, you would order 90 tablets (90 days x 1 tablet per day).

Do you sell prucalopride?

Yes, we sell prucalopride. You can enjoy low prices on this medication. You will need a valid prescription from your healthcare provider to purchase prucalopride from us. We require this to dispense the medication. You can mail, fax, or upload your prescription through your online account.

Do you offer shipping of Motegrity (prucalopride) to the United States?

Yes, we ship Motegrity (prucalopride) to both the United States and Puerto Rico.

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Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Motegrity (Prucalopride Succinate). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Motegrity (Prucalopride Succinate).