Prescription Required
Formulation: Cream
(Brand Option)
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Prescription Required
Formulation: Cream
(Generic Alternative)
Select the prescribed dosage
Select the quantity to see the price.
* This price includes a dispensing fee, medical review fee, and packing fee.
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Estrace Vaginal Cream contains estradiol, a form of estrogen. It is a prescription medication used to treat vaginal and vulvar changes that can happen after menopause when estrogen levels become lower.
These changes are often grouped under the term genitourinary syndrome of menopause (GSM). They can affect the vagina, vulva, and nearby urinary tissues and may cause dryness, irritation, discomfort, or pain.
Before menopause, estrogen helps keep vaginal and vulvar tissues thick, flexible, moist, and well supplied with blood.
After menopause, the ovaries produce much less estrogen. As estrogen levels fall, the vaginal lining can become thinner and drier. The tissues may also lose elasticity and become more sensitive to friction or irritation.
Estrace Vaginal Cream helps replace some of the estrogen activity in these tissues.
Estrace Vaginal Cream is used to treat atrophic vaginitis, which is inflammation and thinning of the vaginal tissues caused by low estrogen levels.
This condition may cause symptoms such as vaginal dryness, burning, itching, irritation, soreness, or discomfort during sexual activity.
Some people may also notice that the vaginal tissues feel more delicate or sensitive than they did before menopause.
Estradiol works directly on estrogen receptors in the vaginal tissues.
This helps the vaginal lining become thicker, healthier, and better able to retain moisture. It can also improve flexibility and reduce irritation caused by fragile or dry tissues.
As treatment continues, symptoms such as dryness, burning, and discomfort may gradually improve.
Estrace Vaginal Cream may also help treat vulvar atrophy, which affects the external tissues around the vaginal opening.
Low estrogen levels can cause these tissues to become thin, dry, irritated, sensitive, or inflamed. This may lead to itching, burning, tenderness, or discomfort with everyday activities.
By providing estrogen to the affected area, Estrace Vaginal Cream helps support the normal structure and function of vulvar tissues.
The tissues may become less dry, less fragile, and more comfortable over time. This can help reduce irritation and improve overall comfort.
Estrace Vaginal Cream belongs to a group of medications called estrogens.
Estradiol binds to estrogen receptors in vaginal and vulvar tissues. This helps support cell growth, tissue thickness, blood flow, and natural moisture.
The result is healthier tissue that is better able to resist dryness, friction, and irritation.
Estrace Vaginal Cream is applied directly to the vaginal area so the medication can act where symptoms are occurring.
Although it is used locally, some estradiol can still be absorbed into the bloodstream. For this reason, it should be used only as directed by your healthcare provider.
With regular use, Estrace Vaginal Cream may help reduce vaginal dryness, itching, burning, irritation, soreness, and pain during sexual activity.
It may also improve the overall condition of vaginal and vulvar tissues by helping them become more flexible, moist, and less fragile.
Improvement may happen gradually rather than immediately. Some symptoms may begin to improve within the first few weeks, while others may take longer.
Use Estrace Vaginal Cream exactly as prescribed and continue treatment for the length of time recommended by your healthcare provider.
Estrace Vaginal Cream helps manage symptoms related to low estrogen, but it does not reverse menopause.
Symptoms may return if treatment is stopped. Your healthcare provider will decide how long you should use the medication based on your symptoms, response to treatment, and overall health.
Estrace Vaginal Cream is applied inside the vagina using the applicator that comes with the medication. Your healthcare provider will tell you how much cream to use and how often to apply it.
The dose and treatment schedule can vary depending on the severity of your symptoms, how well you respond to treatment, and your overall health.
Before using Estrace Vaginal Cream, wash your hands thoroughly with soap and water.
This helps keep the applicator and vaginal area clean and reduces the chance of introducing bacteria during application.
Remove the cap from the tube of Estrace Vaginal Cream.
Attach the applicator securely to the opening of the tube. Make sure it is properly connected before filling it with the medication.
Gently squeeze the tube to fill the applicator with the amount of cream prescribed by your healthcare provider.
The applicator usually has markings that help you measure the correct dose. Do not fill it beyond the amount you were told to use.
Using more cream than prescribed will not make the treatment work faster and may increase the amount of estrogen absorbed into your body.
You can apply Estrace Vaginal Cream while lying on your back with your knees bent or while standing with one foot raised on a chair, stool, or similar surface.
Choose whichever position feels most comfortable and makes it easier to insert the applicator gently.
Carefully insert the applicator into the vagina as far as it comfortably goes.
Do not force it. If you feel pain, strong resistance, or significant discomfort, stop and adjust your position before trying again.
Once the applicator is comfortably in place, slowly press the plunger to release the prescribed amount of cream into the vagina.
After the cream has been released, gently remove the applicator.
If your applicator is reusable, wash it after each application with warm water and mild soap.
Rinse it thoroughly and allow it to air-dry completely before using it again. Follow the cleaning instructions provided with your medication.
Use only the applicator supplied with Estrace Vaginal Cream or one specifically recommended by your healthcare provider or pharmacist.
Applicators from other vaginal products may measure different amounts, which could result in receiving too much or too little medication.
Estrace Vaginal Cream may be prescribed more frequently at the beginning of treatment and then used less often once symptoms improve.
Your healthcare provider will determine the schedule that is most appropriate for you. Do not increase, decrease, or stop treatment without medical guidance.
For the best results, use Estrace Vaginal Cream on the days and at the times recommended by your healthcare provider.
Regular use helps maintain estrogen activity in the vaginal tissues and can gradually improve dryness, irritation, burning, and discomfort.
If you forget a dose, use it when you remember unless it is almost time for your next scheduled application.
If your next dose is approaching, skip the missed dose and continue with your usual schedule. Do not apply extra cream to make up for a missed dose.
Improvement in vaginal dryness, irritation, or discomfort may develop gradually.
Some people notice improvement within the first few weeks, while others may need more time. Continue using the medication exactly as prescribed even if the benefits are not immediate.
Estrace Vaginal Cream contains estrogen, and some of the medication can be absorbed into the bloodstream.
For this reason, use the lowest amount prescribed for the length of time recommended by your healthcare provider. Do not apply extra cream or use it more frequently unless your healthcare provider tells you to do so.
Contact your healthcare provider if you experience persistent vaginal irritation, unusual bleeding, severe pain, or other symptoms that concern you.
Also let your healthcare provider know if your symptoms do not improve or become worse during treatment.
Estrace Vaginal Cream (Estradiol) is available in the following forms and strength:
Using estrogen without a progestin may increase the risk of endometrial cancer in women who still have a uterus.
In some cases, a healthcare provider may prescribe a progestin along with estrogen to help reduce this risk. Report any unusual or unexplained vaginal bleeding to your healthcare provider.
Estrogen therapy may increase the risk of blood clots and stroke.
The risk may be higher if you have other factors such as a history of blood clots, smoking, high blood pressure, or certain heart conditions. Seek immediate medical attention if you develop sudden chest pain, shortness of breath, weakness on one side of the body, or difficulty speaking.
Estrogen therapy may also increase the risk of breast cancer, especially with longer-term use in certain patients.
Tell your healthcare provider if you have a personal or family history of breast cancer or if you notice any breast changes, such as a new lump or unusual tenderness.
Estrace Vaginal Cream may not be appropriate for people with certain medical conditions, including a history of breast cancer, blood clots, or stroke.
Your healthcare provider will review your medical history before deciding whether this treatment is suitable for you.
Use Estrace Vaginal Cream carefully if you have liver disease or a history of jaundice.
Because estrogen is processed by the liver, liver problems may affect how your body handles the medication.
Tell your healthcare provider if you have asthma, diabetes, epilepsy, migraines, or other ongoing medical conditions before starting treatment.
Estrogen can sometimes affect these conditions or change how closely they need to be monitored.
Estrace Vaginal Cream should not be used during pregnancy.
If you are breastfeeding, talk to your healthcare provider before using this medication. Estrogen may pass into breast milk and can also affect milk production.
Estrace Vaginal Cream can interact with certain medications, including some antibiotics, antifungal medicines, and HIV medications.
Tell your healthcare provider about all prescription medicines, over-the-counter products, vitamins, and supplements you take.
If you have a history of high blood pressure, heart disease, or other cardiovascular problems, tell your healthcare provider before using Estrace Vaginal Cream.
Your healthcare provider may monitor you more closely during treatment, especially if you have other risk factors for heart or blood vessel problems.
Use Estrace Vaginal Cream carefully if you have a history of uterine fibroids or endometriosis.
Estrogen can sometimes affect conditions that respond to hormones, so your healthcare provider may want to monitor your symptoms during treatment.
Tell your healthcare provider if you have had an abnormal mammogram or other breast-related findings.
Your healthcare provider may recommend additional evaluation or regular breast monitoring while you are using estrogen therapy.
Long-term estrogen therapy has been associated with a possible increased risk of ovarian cancer in some studies.
Your healthcare provider will consider your individual risk factors and recommend the lowest effective dose for the shortest appropriate treatment period.
Estrace Vaginal Cream is used to treat vaginal and vulvar symptoms caused by lower estrogen levels after menopause. It can help relieve vaginal dryness, itching, burning, irritation, and pain during sexual activity. The medication works by replacing some of the estrogen activity in the vaginal tissues, helping them become healthier, more flexible, and better moisturized.
Estrace Vaginal Cream should not be used during pregnancy. If you are breastfeeding, talk to your healthcare provider before using this medication. Estrogen may pass into breast milk and can also affect milk production. Your healthcare provider can help determine whether treatment is appropriate for you.
Yes. Estrace Vaginal Cream may interact with certain medications, including some antibiotics, antifungal medicines, and HIV medications. Before starting treatment, tell your healthcare provider about all prescription medications, over-the-counter medicines, vitamins, and supplements you use. This allows them to check for possible interactions and decide whether any changes to your treatment are needed.
| Generic name: | Estradiol |
|---|---|
| Formulation: | Cream, Vaginal Cream |
| Strength(s): | 0.01% |
| Quantities Available: | 42.5g |
Our online Canadian Pharmacy is known for high standards of quality, safety, and efficiency when it comes to medications.
Our pharmacy offers lower prices on prescription drugs compared to traditional pharmacies.
When ordering Estrace Vaginal Cream (estradiol) from a Canadian pharmacy, you can typically purchase up to a 90-day supply at one time, which is common for prescription medications to ensure adequate management of chronic conditions without frequent refills.
Here’s what you need to know:
Dosage and Quantity: Estrace Vaginal Cream is commonly prescribed in dosages of 1 gram to 4 grams, applied intravaginally daily initially and then reduced to a maintenance dose of 1 gram applied 1 to 3 times per week. For a 90-day supply, the quantity you would order will depend on your prescribed dosage and frequency of use.
Yes, we do sell estradiol on our website. You can enjoy our low prices, but please note that you will need a valid prescription from your healthcare provider to purchase this medication. We require a prescription to dispense the medication, and you have the option to mail, fax, or upload your prescription through your online account for processing.
Yes, we ship Estrace Vaginal Cream (estradiol) to both the United States and Puerto Rico.
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Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Estrace Vaginal Cream (Estradiol). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Estrace Vaginal Cream (Estradiol).
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