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Daraprim (active ingredient: pyrimethamine) is a prescription antiparasitic medication used to treat certain infections caused by parasites. In current U.S. prescribing information, Daraprim is specifically indicated for the treatment of toxoplasmosis when used together with a sulfonamide antibiotic.
Toxoplasmosis
Daraprim is used to treat toxoplasmosis, an infection caused by the parasite Toxoplasma gondii.
Many people who become infected have mild symptoms or no symptoms at all. However, toxoplasmosis can become serious in people with weakened immune systems and may also affect the eyes, brain, or other organs.
Daraprim is generally used together with a sulfonamide, such as sulfadiazine, because the two medicines work together to improve treatment effectiveness.
Daraprim is usually not used by itself for toxoplasmosis.
Pyrimethamine and a sulfonamide block different steps in the parasite’s folate pathway. Using them together produces a stronger antiparasitic effect than using either medicine alone.
Treatment commonly also includes leucovorin (folinic acid) to help protect healthy blood-forming cells from the effects of pyrimethamine on folate metabolism.
Daraprim belongs to a group of medicines known as antifolate antiparasitic agents.
Blocks Folate Metabolism in Parasites
Parasites such as Toxoplasma gondii need folate-related compounds to make DNA and reproduce.
Pyrimethamine blocks an enzyme called dihydrofolate reductase in the parasite. This interferes with the parasite’s ability to produce the folate it needs for growth and replication.
As a result, the parasite’s ability to multiply is reduced.
Helps Stop the Infection From Progressing
By slowing the parasite’s growth, Daraprim allows the immune system and the other medicines in the treatment regimen to help bring the infection under control.
Daraprim does not immediately eliminate every parasite from the body, so treatment must be taken for the full period recommended by your healthcare provider.
The original description lists treatment and prevention of malaria as current Daraprim indications. That information reflects older labeling and historical use of pyrimethamine.
Current U.S. Daraprim prescribing information lists treatment of toxoplasmosis with a sulfonamide as its approved indication.
Pyrimethamine has historically been used as an antimalarial, but widespread parasite resistance has greatly limited its role. It should not be described as a standard current treatment or preventive medicine for chloroquine-resistant malaria without specifying the particular combination product, country, and treatment guideline.
Daraprim is not a conventional antibacterial antibiotic.
It targets specific biochemical processes needed by certain parasites. This is why it is used for infections such as toxoplasmosis rather than common bacterial infections.
Daraprim is a potent medication that can interfere with folate metabolism in both parasites and human cells. For this reason, treatment requires careful dosing and medical monitoring.
Use Daraprim exactly as directed by your healthcare provider and do not change the dose or stop treatment on your own.
Daraprim tablets are taken by mouth. Take the medication exactly as directed by your healthcare provider. Do not take a larger or smaller dose, take it more often, or stop treatment early unless your healthcare provider tells you to do so.
Daraprim may cause nausea, loss of appetite, or vomiting in some people.
If the medication upsets your stomach, taking it with food may help reduce nausea and vomiting. If vomiting becomes severe or continues, contact your healthcare provider. Your dose or treatment plan may need to be adjusted.
Take Daraprim for the full length of time prescribed, even if you start to feel better.
Skipping doses, lowering the dose on your own, or stopping treatment too soon may make the infection harder to control. Do not change your treatment without speaking with your healthcare provider.
For adults being treated for toxoplasmosis, the labeled starting dose of Daraprim is generally 50 to 75 mg daily. It is used together with 1 to 4 g daily of a sulfonamide.
The initial doses are usually continued for about 1 to 3 weeks, depending on how well the infection responds and how well the medicines are tolerated. After this period, the doses may be reduced to approximately one-half of the initial amount and continued for another 4 to 5 weeks.
The exact dose and duration must be determined by your healthcare provider.
Daraprim is not normally used by itself to treat toxoplasmosis.
It is combined with a sulfonamide because the two medicines act on different steps in the parasite’s folate pathway and work better together than either medicine alone.
Pyrimethamine can also interfere with folate metabolism in healthy human cells. This can reduce the body’s production of blood cells and potentially cause serious bone marrow suppression.
For this reason, folinic acid (leucovorin) is generally given with pyrimethamine-containing toxoplasmosis treatment to help protect healthy blood-forming cells.
Your healthcare provider will determine the appropriate leucovorin dose and how long you should take it.
Because Daraprim can affect blood cell production, your healthcare provider may order blood tests during treatment.
These tests help monitor your red blood cells, white blood cells, and platelets and allow your healthcare provider to identify possible bone marrow suppression early.
Contact your healthcare provider promptly if you develop unusual weakness, pale skin, fever, sore throat, unusual bruising, or bleeding during treatment.
In children, Daraprim dosing is based partly on age and body weight and must be determined carefully by a healthcare provider.
Do not give a child an adult dose of Daraprim unless it has specifically been prescribed.
The original text includes a malaria dosing section, but this should be updated.
Current U.S. Daraprim labeling lists toxoplasmosis in combination with a sulfonamide as the approved indication.
Although pyrimethamine was historically used to treat and prevent malaria, widespread resistance has greatly limited its role. It should not be described as routinely given with artesunate for malaria under the current U.S. Daraprim label.
Pyrimethamine has a relatively narrow therapeutic range when used for toxoplasmosis. Taking too much can significantly increase the risk of folate deficiency and bone marrow toxicity.
Never increase your dose because you feel that the medication is not working quickly enough. Contact your healthcare provider if your symptoms are not improving.
Take Daraprim exactly as prescribed and complete the recommended course of treatment. For toxoplasmosis, it is generally used with a sulfonamide and folinic acid (leucovorin) rather than by itself. Regular blood monitoring may also be required because pyrimethamine can suppress blood cell production.
Daraprim (Pyrimethamine) is available in the following forms and strength:
Daraprim should be used carefully in people with kidney or liver problems.
Tell your healthcare provider if you have reduced kidney function, liver disease, or a history of liver problems before starting treatment. Your healthcare provider may decide that closer monitoring is needed.
Pyrimethamine interferes with folate metabolism, so people who already have low folate levels may be more likely to develop blood-related side effects.
Daraprim should be used with caution if you have a condition that can cause folate deficiency, such as malabsorption, alcoholism, or treatment with medicines that lower folate levels.
Daraprim should not be used in people with documented megaloblastic anemia caused by folate deficiency.
Pyrimethamine can suppress the bone marrow and reduce the body’s production of blood cells.
This may lead to:
Your healthcare provider may order regular blood tests during treatment to monitor your blood cell counts.
Folinic acid, also called leucovorin, is commonly given with pyrimethamine treatment to help protect healthy blood-forming cells.
If signs of folate deficiency or bone marrow suppression develop, the prescribing information recommends stopping pyrimethamine and giving folinic acid until normal blood-cell production returns.
Tell your healthcare provider if you have glucose-6-phosphate dehydrogenase (G6PD) deficiency or another inherited blood disorder before starting treatment.
The original statement that pyrimethamine itself routinely causes hemolytic anemia specifically because of G6PD deficiency is too broad. In toxoplasmosis treatment, Daraprim is usually combined with a sulfonamide, and the entire treatment regimen and your blood-cell counts should be monitored carefully.
Daraprim is not automatically prohibited during pregnancy, but it should be used only when the healthcare provider determines that the potential benefit justifies the potential risk to the fetus.
If Daraprim is used during pregnancy, concurrent treatment with folinic acid is strongly recommended.
Tell your healthcare provider if you are pregnant, think you may be pregnant, or are planning a pregnancy before starting treatment.
Daraprim may cause gastrointestinal side effects such as nausea, vomiting, or loss of appetite.
Rash may also occur, particularly when pyrimethamine is used with a sulfonamide. Contact your healthcare provider if side effects become severe, persistent, or difficult to tolerate.
Do not use Daraprim if you are allergic to pyrimethamine or any ingredient in the medication.
Contact your healthcare provider promptly if you develop a significant rash. Seek urgent medical attention for symptoms of a serious allergic reaction, such as difficulty breathing or swelling of the face, lips, tongue, or throat.
Tell your healthcare provider about all prescription medicines, over-the-counter medications, vitamins, and supplements you take.
Medicines that also interfere with folate or suppress bone marrow can increase the risk of serious blood-related side effects when combined with pyrimethamine. Examples include trimethoprim-sulfamethoxazole, proguanil, zidovudine, methotrexate, and certain other cytotoxic medicines.
Tell your healthcare provider if you have a seizure disorder or take anticonvulsant medications.
Some medicines, including phenytoin, can affect folate levels and may increase the risk of folate deficiency during pyrimethamine treatment. The Daraprim label also recommends a lower starting approach in patients with seizure disorders because pyrimethamine can cause nervous system toxicity at excessive doses.
Do not start folic acid, folinic acid, or another vitamin supplement specifically to manage Daraprim treatment without discussing it with your healthcare provider.
For pyrimethamine toxicity prevention, folinic acid (leucovorin) is the form specifically recommended in the prescribing information. Your healthcare provider will determine the appropriate type and amount of supplementation.
Daraprim can cause serious blood-related side effects because it interferes with folate metabolism. Regular medical monitoring is important, particularly during higher-dose treatment for toxoplasmosis.
Tell your healthcare provider promptly if you develop unusual tiredness, pale skin, fever, sore throat, mouth sores, unusual bruising, or bleeding while taking Daraprim.
Daraprim is taken by mouth as a tablet. It may be taken with or without food. If it causes nausea or vomiting, taking it with food may make it easier to tolerate. The exact dose and length of treatment depend on the condition being treated, your age, your response to therapy, and other medical factors. Take Daraprim exactly as directed by your healthcare provider.
Yes. Daraprim is approved for the treatment of toxoplasmosis when it is used together with a sulfonamide antibiotic. The combination is more effective because the two medicines interfere with different steps in the parasite’s folate pathway. Folinic acid, also called leucovorin, is also commonly used during pyrimethamine treatment to help reduce the risk of serious blood-related side effects.
Daraprim may be used during pregnancy when a healthcare provider determines that the potential benefits outweigh the possible risks. Because pyrimethamine interferes with folate metabolism, treatment during pregnancy requires careful medical supervision. Tell your healthcare provider if you are pregnant, think you may be pregnant, or are planning a pregnancy before taking Daraprim.
Yes. Daraprim can be used in children for the treatment of toxoplasmosis when appropriate. Pediatric dosing is different from adult dosing and may be based on the child’s age and body weight. A healthcare provider should determine the exact dose and duration of treatment.
The original statement should be updated. Current U.S. Daraprim labeling lists toxoplasmosis, not malaria, as its approved indication. Pyrimethamine was historically used for malaria, but widespread parasite resistance has greatly limited this use. Daraprim should therefore not be described as a routine current treatment for malaria in adults or children under the present U.S. label.
| Generic name: | Pyrimethamine |
|---|---|
| Formulation: | Tablet |
| Strength(s): | 25mg |
| Quantities Available: | 30, 60, 90 |
Our online Canadian Pharmacy is known for high standards of quality, safety, and efficiency when it comes to medications.
Our pharmacy offers lower prices on prescription drugs compared to traditional pharmacies.
When ordering Daraprim (pyrimethamine) from a Canadian pharmacy, you can typically purchase up to a 90-day supply at one time, which is common for prescription medications to ensure adequate management of conditions without frequent refills.
Here’s what you need to know:
Dosage and Quantity: Daraprim is commonly prescribed in dosages of 25 mg tablets, typically taken once daily. For a 90-day supply, this means you would order 90 tablets (90 days x 1 tablet per day).
No, we do not sell pyrimethamine directly. However, you can still enjoy low prices on Daraprim, which contains pyrimethamine as an active ingredient. You will need a valid prescription from your healthcare provider to order Daraprim. We require this prescription to dispense the medication. You can submit your prescription by mail, fax, or upload it through your online account with us.
Yes, we ship Daraprim (pyrimethamine) to both the United States and Puerto Rico.
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Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Daraprim (Pyrimethamine). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Daraprim (Pyrimethamine).
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