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Crixivan

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Prescription Prescription Required FormationFormulation: Capsule

Indinavir

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Crixivan (indinavir) is a prescription medication used to treat human immunodeficiency virus (HIV) infection. HIV is a virus that attacks your immune system, making it harder for your body to fight infections and diseases.

Crixivan is used together with other HIV medications, known as antiretroviral drugs, to help control the virus and protect your immune system.

HIV Infection

Crixivan helps reduce the amount of HIV in your blood, also known as your viral load. When the amount of virus decreases, your immune system has a better chance of staying healthy and fighting infections. Taking Crixivan with other HIV medications can help slow the progression of HIV and reduce the risk of serious health problems, including acquired immunodeficiency syndrome (AIDS). Regular treatment can also help you maintain your overall health and quality of life.

Crixivan does not cure HIV, but it can help keep the virus under control when taken as part of an effective HIV treatment plan. It is important to take your medications exactly as prescribed, even if you feel healthy and have no symptoms.

Crixivan is an older HIV medication and is not commonly used in modern HIV treatment because newer medications are generally easier to take and have fewer side effects. Your doctor will determine whether Crixivan is appropriate for your condition.

How Does Crixivan Work?

Crixivan belongs to a group of HIV medications called protease inhibitors. These medications work by blocking an enzyme that HIV needs to make new copies of itself.

When HIV enters your body, it attacks certain immune cells called CD4 cells. These cells play an important role in helping your body fight infections. The virus uses these cells to produce more copies of itself, which can gradually weaken your immune system.

HIV needs an enzyme called protease to produce mature, infectious virus particles. Crixivan blocks this enzyme, preventing the virus from making properly functioning new copies.

By blocking HIV protease, Crixivan helps:

  • Reduce Your Viral Load: It lowers the amount of HIV in your blood, helping keep the infection under control.
  • Protect Your Immune System: By reducing HIV activity, Crixivan helps your body maintain or recover CD4 cells, which are important for fighting infections.
  • Slow HIV Progression: Keeping your viral load low helps reduce the risk of developing serious HIV-related illnesses and complications.
  • Support Long-Term HIV Management: When taken with other HIV medications, Crixivan helps control the virus and reduce the chance of HIV becoming resistant to treatment.

Crixivan works best when taken consistently with other prescribed HIV medications. Skipping doses or stopping treatment can allow the virus to multiply again and may increase the risk of drug resistance. This means the medication may become less effective at controlling HIV.

Although Crixivan cannot remove HIV completely from your body, effective HIV treatment can lower your viral load to an undetectable level. People who maintain an undetectable viral load do not transmit HIV through sex. This is known as Undetectable = Untransmittable (U=U).

Continue taking your medication as prescribed and attend regular medical appointments. Your doctor will monitor your viral load, CD4 cell count, and overall health to make sure your HIV treatment is working properly.

Crixivan is a prescription medication used with other HIV medicines to help control HIV infection. It comes in capsules that you take by mouth.

The usual adult dose of Crixivan is 800 mg every 8 hours, or three times a day. However, your doctor may prescribe a different dose depending on your medical condition, other medications, and how your body responds to treatment.

Try to take Crixivan at the same times each day. Keeping a regular schedule helps maintain the right amount of medication in your body and reduces the risk of HIV becoming resistant to treatment.

Follow the instructions on your prescription label carefully. Do not take more or less medication than prescribed.

How to Take Crixivan Capsules

Follow these instructions to take Crixivan safely and correctly:

  1. Take your medication on schedule: Crixivan is usually taken every 8 hours. Set reminders to help you remember your doses.
  2. Swallow the capsule with water: Take the capsule with a full glass of water. Do not crush or chew it. If you have trouble swallowing capsules, ask your pharmacist about your options before opening them.
  3. Take it on an empty stomach: For the usual Crixivan regimen, take your dose at least 1 hour before eating or 2 hours after a meal. This helps your body absorb the medication properly.
  4. Choose the right foods if needed: If Crixivan upsets your stomach, you may take it with a small, low-fat meal, such as dry toast or cornflakes with skim milk. Avoid taking it with large meals or meals that are high in fat, calories, or protein, unless your doctor gives you different instructions.
  5. Drink enough water: Crixivan can increase your risk of kidney stones. Adults are generally advised to drink at least 1.5 litres of fluids throughout the day to help reduce this risk, unless their doctor has recommended a fluid restriction.
  6. Continue your treatment: Keep taking Crixivan and your other prescribed HIV medications, even if you feel healthy. Do not stop treatment without speaking to your doctor.

Taking Crixivan With Food and Drinks

Crixivan is usually taken on an empty stomach because food can affect how much medication your body absorbs.

You can generally take your dose with water or drinks such as skim milk, juice, coffee, or tea. However, water is a good choice because staying hydrated is especially important while taking Crixivan.

If you experience stomach discomfort, a small, low-fat snack may help. Examples include dry toast, plain cornflakes, or cornflakes with skim milk.

Ask your doctor or pharmacist which foods and drinks are suitable for your prescribed treatment plan, especially if you are taking other HIV medications.

Important Tips When Taking Crixivan

  • Take every dose as prescribed: Taking Crixivan regularly helps keep HIV under control and reduces the risk of drug resistance.
  • Do not change your dose: Never take extra capsules or change your dosing schedule without your doctor’s approval.
  • Stay hydrated: Drink enough fluids throughout the day to help lower your risk of kidney stones.
  • Keep taking your other HIV medications: Crixivan must be taken with other antiretroviral medications to treat HIV effectively.
  • Watch for side effects: Tell your doctor if you develop severe stomach pain, vomiting, unusual tiredness, blood in your urine, or other concerning symptoms.
  • Attend regular checkups: Your doctor may recommend blood tests to check your viral load, kidney function, and liver health.

When to Contact Your Doctor

Contact your doctor if you have difficulty swallowing your medication, experience ongoing nausea or vomiting, or have trouble following your dosing schedule.

Seek prompt medical attention if you experience severe back or side pain, blood in your urine, difficulty urinating, or signs of dehydration. These symptoms may indicate kidney stones or other kidney problems.

If you develop serious side effects, your doctor may need to adjust your dose, temporarily interrupt treatment, or prescribe another HIV medication. Do not stop taking Crixivan on your own, as this can allow HIV to multiply and make your treatment less effective.

Taking Crixivan Capsules

Crixivan capsules should be swallowed whole whenever possible. Do not crush or chew them. If you have difficulty swallowing capsules, you may be able to open them and mix the contents with a small amount of fruit puree, such as mashed banana. Ask your doctor or pharmacist how to do this correctly.

Take Crixivan at the same times each day to help keep a steady amount of medication in your body. Follow the instructions on your prescription label carefully, and ask your doctor or pharmacist if you have questions about your dose or treatment schedule. 

If you experience side effects, tell your doctor. They may need to adjust your treatment or temporarily stop the medication. Do not make these changes on your own.

Common Side Effects of Crixivan (Indinavir):

  • Altered sense of taste
  • Back pain
  • Changes in appetite
  • Changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist)
  • Diarrhea
  • Dizziness
  • Dry skin
  • Headache
  • Heartburn
  • Indigestion
  • Itching
  • Nausea
  • Rash
  • Sneezing
  • Sore throat
  • Stomach pain
  • Stuffy nose
  • Tiredness
  • Vomiting
  • Weakness

Serious Side Effects of Crixivan (Indinavir):

  • Anxiety
  • Blood in your urine
  • Blurred vision
  • Chest pain
  • Clay-colored stool
  • Cold sores
  • Confusion
  • Dark-colored urine
  • Difficulty breathing
  • Drowsiness
  • Dry cough
  • Dry mouth
  • Dry skin
  • Fever
  • Fruity breath odor
  • Hives
  • Hunger
  • Impotence and
  • Increased thirst
  • Increased urination
  • Irritableness
  • Itching
  • Loss of appetite
  • Loss of bladder or bowel control
  • Loss of interest in sex
  • Menstrual changes
  • Mouth sores
  • Night sweats
  • Pain in your side or lower back
  • Painful or difficult urination
  • Pale or yellowed skin
  • Problems with eye movement
  • Rapid heart rate
  • Severe lower back pain
  • Shortness of breath
  • Sores on your genital or anal area
  • Stomach pain
  • Swelling in your neck or throat (enlarged thyroid)
  • Swelling of your face, lips, tongue, or throat
  • Swollen glands
  • Tenderness
  • Tired feeling
  • Trouble speaking or swallowing
  • Unexplained muscle pain
  • Unusual tiredness
  • Upper stomach pain
  • Weakness or prickly feeling
  • Weakness with fever
  • Weight loss
  • Wheezing
  • Yellowing of the skin or eyes (jaundice)

Crixivan (Indinavir) is available in the following forms and strength:

Indinavir: Capsule

  • 400 mg

Before taking Crixivan, tell your doctor about any medical conditions, allergies, or medications you are taking. Although Crixivan helps control HIV infection, it can cause serious side effects in some people. Your doctor may recommend regular blood tests and medical checkups to make sure the medication is safe and working properly.

Drug Interactions

Crixivan can interact with many medications, including certain prescription drugs, over-the-counter medicines, and herbal supplements. Some interactions can increase the amount of medication in your body, raising your risk of serious side effects. Others can make Crixivan less effective at controlling HIV. Tell your doctor or pharmacist about everything you take before starting treatment. Do not start, stop, or change any medication without checking with your healthcare provider.

Liver Problems

Crixivan may affect how your liver works and can sometimes cause liver damage. Your risk may be higher if you already have liver disease, hepatitis B, or hepatitis C. Your doctor may recommend blood tests to check your liver function during treatment. Contact your doctor immediately if you notice yellowing of your skin or eyes, dark urine, unusual tiredness, or pain in the upper right side of your abdomen.

Kidney Stones and Kidney Problems

Crixivan can increase your risk of developing kidney stones and other kidney problems. This risk may be greater if you have a history of kidney disease, kidney stones, or dehydration. Drinking enough water throughout the day can help lower your risk. Adults taking Crixivan are generally advised to drink at least 1.5 liters of fluids daily, unless their doctor recommends otherwise. Contact your doctor right away if you experience severe back or side pain, blood in your urine, or difficulty urinating.

Antidepressant Interactions

Crixivan may interact with certain antidepressants and other medications that affect serotonin levels. Some combinations may increase your risk of side effects, and certain interacting drugs may contribute to serotonin syndrome, a potentially serious condition. Symptoms can include agitation, confusion, fever, sweating, a fast heartbeat, and muscle stiffness. Tell your doctor if you take medication for depression, anxiety, or another mental health condition. Your doctor can check for interactions and adjust your treatment if needed.

Severe Skin Reactions

Crixivan may cause skin reactions, including itching, redness, or a rash. In rare cases, serious skin reactions such as Stevens-Johnson syndrome may occur. This condition can cause painful skin blisters, peeling skin, fever, and sores in your mouth or eyes. Seek emergency medical attention if you develop a severe rash, blistering, or skin peeling, especially if you also have a fever.

Stomach and Digestive Problems

Crixivan may cause nausea, vomiting, diarrhea, or stomach discomfort. These symptoms are often mild, but they can sometimes make it difficult to eat, drink, or take your medication regularly. Contact your doctor if you experience severe or ongoing digestive problems. Vomiting and diarrhea can also lead to dehydration, which may increase your risk of kidney problems while taking Crixivan.

Increased Bleeding Risk

If you have hemophilia, Crixivan may increase your risk of bleeding. Some people with hemophilia who take HIV protease inhibitors have experienced more frequent bleeding episodes, including bleeding into joints or muscles. Tell your doctor if you have a bleeding disorder or take blood-thinning medications. Contact your doctor if you notice unusual bruising, frequent nosebleeds, or bleeding that takes longer than normal to stop.

Diabetes and Blood Sugar Changes

Crixivan may increase your blood sugar levels or make existing diabetes harder to control. In some cases, people taking protease inhibitors have developed new diabetes or experienced worsening blood sugar control. Your doctor may recommend checking your blood sugar regularly during treatment. Contact your healthcare provider if you experience increased thirst, frequent urination, unusual hunger, or unexplained weight changes.

Heart and Cardiovascular Health

HIV treatment with certain protease inhibitors may contribute to changes in blood sugar and blood fat levels, which can affect your long-term heart health. Your risk may be higher if you smoke, have high cholesterol, or have a history of heart disease. Tell your doctor about any heart-related conditions before starting Crixivan. Your doctor may monitor your cholesterol, blood pressure, and blood sugar during treatment. Maintaining a healthy diet, staying physically active, and avoiding smoking can also support your heart health.

Pancreatitis and High Triglycerides

Tell your doctor if you have a history of pancreatitis, which is inflammation of the pancreas, or high triglyceride levels. Certain HIV medications can affect blood fat levels, and very high triglycerides can increase the risk of pancreatitis. Contact your doctor immediately if you develop severe upper abdominal pain, especially if the pain spreads to your back or occurs with ongoing nausea and vomiting.

Herbal Supplements

Some herbal products can interact with Crixivan and make it less effective. In particular, do not take St. John’s wort while using Crixivan. This herbal supplement can lower the amount of Crixivan in your blood, allowing HIV to multiply and increasing the risk of drug resistance. Always tell your doctor or pharmacist about any herbal products, natural remedies, or supplements you use.

When to Contact Your Doctor

Contact your doctor if you experience ongoing nausea, vomiting, unusual bruising, changes in your blood sugar, or any new symptoms while taking Crixivan. Your doctor may recommend blood tests to monitor your liver, kidneys, blood sugar, and cholesterol levels.

Seek immediate medical attention if you develop severe back or side pain, blood in your urine, yellowing of your skin or eyes, a severe skin rash, or signs of a serious allergic reaction.

Continue taking Crixivan and your other HIV medications exactly as prescribed. Do not stop or change your treatment without medical advice, as this can allow HIV to multiply and increase the risk of drug resistance.

Can I take Crixivan during pregnancy?

Crixivan is generally not recommended during pregnancy because there is limited information about its safety and effectiveness for pregnant women. Pregnancy can also affect how your body absorbs and processes the medication, which may make it harder to control HIV. If you are pregnant, planning to become pregnant, or think you might be pregnant, tell your doctor right away. Your doctor can help you choose an HIV treatment that is safer and more effective during pregnancy. Proper HIV treatment is important because it helps protect your health and greatly reduces the risk of passing HIV to your baby. Do not stop taking Crixivan or your other HIV medications without speaking to your doctor. Stopping treatment can cause the virus to multiply and increase the risk of complications.

What should I avoid while taking Crixivan?

While taking Crixivan, avoid medications and supplements that may interfere with your HIV treatment. Crixivan can interact with certain antibiotics, antifungal medications, heart medications, and other prescription drugs. These interactions may increase your risk of serious side effects or make your HIV treatment less effective. You should also avoid St. John’s wort, an herbal supplement sometimes used for mood problems, because it can lower the amount of Crixivan in your blood. It is best to limit or avoid alcohol, especially if you have liver problems. Alcohol does not have a specific known direct interaction with Crixivan, but heavy drinking can affect your liver health and make it harder to follow your treatment schedule. Crixivan is usually taken on an empty stomach, so avoid taking it with large or high-fat meals unless your doctor gives you different instructions. Drink enough water throughout the day to help reduce your risk of kidney stones. Always ask your doctor or pharmacist before starting any new medication or supplement.

Can I breastfeed while taking Crixivan?

It is not known whether Crixivan passes into human breast milk. Because there is limited information about its effects on nursing infants, Crixivan is generally not recommended during breastfeeding. HIV can also pass from a parent to their baby through breast milk. Recommendations about breastfeeding with HIV depend on your viral load, HIV treatment, access to safe formula, and local medical guidelines. If you are living with HIV and planning to breastfeed, speak with your HIV specialist before making a decision. Your healthcare team can explain the risks and benefits and help you choose the safest feeding option for your baby. Do not stop taking your HIV medication without medical advice.

How long does it take for Crixivan to start working?

Crixivan starts blocking HIV from making new copies of itself after you begin taking the medication. When used with other effective HIV medicines, it can begin lowering the amount of virus in your blood within the first few weeks of treatment. You may notice a reduction in your viral load within 2 to 4 weeks, although the exact timing varies from person to person. Reaching an undetectable viral load may take several months, depending on your starting viral load, treatment plan, and how consistently you take your medication. Your doctor will perform regular blood tests to check your viral load and see how well your treatment is working. Even if you feel healthy or your viral load becomes undetectable, continue taking Crixivan and your other HIV medications exactly as prescribed. HIV treatment must be continued to keep the virus under control and reduce the risk of drug resistance. For breastfeeding, current HIV treatment guidelines recommend discussing feeding options with an HIV specialist. When HIV treatment maintains an undetectable viral load, the risk of HIV transmission through breastfeeding is less than 1%, but it is not zero. Formula or pasteurized donor milk eliminates that route of HIV transmission. 

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Additional Information Book
Generic name:

Indinavir

Formulation:

Capsule

Strength(s):

400mg

Quantities Available:

90

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How to Order

How much Crixivan can I order at once from a Canadian pharmacy?

When ordering Crixivan (indinavir) from a Canadian pharmacy, you can typically purchase up to a 90-day supply at one time, which is common for prescription medications to ensure adequate management of conditions without frequent refills.

Here’s what you need to know:

Dosage and Quantity: Crixivan is available in 400 mg capsules. The usual dosage is 800 mg taken every 8 hours, which means 2 capsules of 400 mg per dose. For a 90-day supply, this means you would order 540 capsules (90 days x 3 doses per day x 2 capsules per dose).

Do you sell indinavir?

Yes, we sell indinavir on our website. You can enjoy low prices when you order through us. To purchase indinavir, you will need a valid prescription from your healthcare provider. We require this prescription to dispense the medication safely and appropriately. You have the option to submit your prescription by mailing it to us, faxing it, or uploading it through your online account.

Do you offer shipping of Crixivan (indinavir) to the United States?

Yes, we ship Crixivan (indinavir) to both the United States and Puerto Rico.

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Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Crixivan (Indinavir). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Crixivan (Indinavir).