Indications
Videx EC (generically known as Didanosine) is a prescription medication used to treat human immunodeficiency virus (HIV) infections. It is sometimes used to treat hepatitis B virus infections as well. Pancreatitis and lactic acidosis are serious risks associated with the medication.
Didanosine belongs to the class of medications called nucleoside reverse transcriptase inhibitors (NRTIs) and is used in combination with other HIV medications to help control HIV infection. It works by decreasing the amount of HIV in the body, allowing the immune system to function better.
Use and Dosage
Videx comes in the form of EC capsules to take it by mouth usually taken once daily on an empty stomach, at least 30 minutes before or 2 hours after a meal. Swallow the capsules whole. Do not crush, chew, or open the capsules. Doing so may decrease their effectiveness. If a patient has difficulty swallowing the capsule whole, they should inform their healthcare provider, who may consider alternative treatment options or administering the medication in a different form, such as pediatric powder, for patients who cannot swallow capsules.
The recommended dosage of Videx EC (didanosine) depends on the patient's age, weight, and kidney function. The recommended total daily dose for adult and pediatric patients is typically between 200-400mg, taken once daily on an empty stomach. For pediatric patients, the weight cutoffs may vary based on the formulation of the medication. Therefore, patients with kidney insufficiency adjust the dosage of Videx, as recommended by their healthcare provider. Overall, patients should follow the dosing instructions provided by their healthcare provider and should not adjust their dosage without first consulting their provider.
Take the capsules exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Side Effects
Common Side Effects of Videx EC (Didanosine):
- Abdominal pain
- Diarrhea
- Dizziness
- Dry eyes
- Dryness of mouth
- Gas
- Headache
- Heartburn
- Increased breathing rate
- Loss of appetite
- Nausea
- Rapid heart rate
- Rash
- Unusual tiredness
- Vomiting
Serious Side Effects of Videx EC (Didanosine):
- Abdominal pain
- Blood in stools
- Blood in the urine
- Bloody nose
- Coughing blood
- Cuts that don't stop bleeding
- Dark urine
- Diarrhea
- Fever and/or chills
- Fruity smell to the breath
- Headache
- Increased fat on the upper back, neck, and breasts
- Increased thirst
- Increased urination
- Listlessness
- Loss of appetite
- Loss of fat from the legs, arms, and face
- Muscle aches
- Nausea
- Pale stools
- Prolonged dizziness
- Severe diarrhea
- Shortness of breath
- Stiff neck
- Tingling, burning, or numbness and pain in the hands or feet
- Vision changes
- Weight loss
- Yellowing of the skin or whites of the eyes
Forms and Strength
Videx EC (Didanosine) is available in the following forms and strength:
Videx EC: EC Capsule
- 125 mg
- 200 mg
Didanosine: EC Capsule
- 250 mg
- 400 mg
Cautions
- Videx EC can cause pancreatitis, lactic acidosis, and serious liver problems.
- Deaths from lactic acidosis have been reported in pregnant women receiving the combination of didanosine and stavudine. There may be drug interactions with Videx EC.
- Videx EC requires precautions for use in patients with liver disease, peripheral neuropathy, and other medical conditions.
- The drug should be used with caution during pregnancy or breastfeeding.
- Some side effects of Videx EC include abdominal pain, diarrhea, nausea, vomiting.
- Videx EC is still available in the delayed-release capsules and pediatric powder for oral solution formulations.
- Patients who are overweight or have a history of pancreatitis or alcohol abuse may be at an increased risk of developing pancreatitis while taking Videx EC.
- The drug is not recommended for use in patients with pre-existing liver disease or those with a history of liver problems.
- Videx EC may cause a decrease in bone mineral density, which may lead to osteoporosis or fractures.
- The medication should not be used in combination with some other medications, such as tenofovir disoproxil fumarate, due to an increased risk of toxicity.
- Patients taking Videx EC should be closely monitored for signs of immune reconstitution syndrome, a syndrome where patients may develop new infections due to their improved immune system function.
- Some patients may experience a hypersensitivity reaction to Videx EC, which can be potentially life-threatening.
- Kidney problems and renal failure have been reported in patients taking Videx EC, particularly in those with certain risk factors such as dehydration.
- Patients taking Videx EC should avoid alcohol and certain acidic foods and beverages, as they can increase the risk of gastrointestinal side effects and decrease the effectiveness of the medication.
Frequently Asked Questions (FAQ)
How long do I need to take Videx EC for?
The length of treatment with Videx EC depends on the individual patient's condition and response to treatment. Patients should continue taking the medication as prescribed by their healthcare provider and should not stop taking it without first consulting their provider.
What should I do if I experience side effects while taking Videx EC?
Patients should inform their healthcare provider if they experience any side effects while taking Videx EC, particularly serious side effects such as pancreatitis, lactic acidosis, or liver problems.
Can Videx EC be used in pediatric patients?
Yes, Videx EC can be used in pediatric patients, but dosing recommendations may differ from those used in adult patients.
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