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Xulane (norelgestromin/ethinyl estradiol transdermal system) Shopper Approved

Prescription Prescription Required FormationFormulation: Patch

Xulane

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Prescription Prescription Required FormationFormulation: Patch

norelgestromin/ethinyl estradiol transdermal system

(Generic Alternative)

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Xulane is a prescription birth-control patch used to help prevent pregnancy. It contains two hormones: norelgestromin, which is a progestin, and ethinyl estradiol, which is an estrogen.

The patch is worn on the skin and slowly releases these hormones into the bloodstream. Unlike birth-control pills, which must be taken every day, Xulane is usually changed once a week according to a specific four-week schedule.

Who May Use Xulane?

Xulane is intended for people of reproductive age who want a reversible form of hormonal birth control.

A healthcare provider will consider several factors before prescribing it, including:

  • Age
  • Body weight and body mass index
  • Smoking status
  • Blood pressure
  • Personal and family medical history
  • Risk of blood clots
  • Other medications being taken

Xulane may not be suitable for everyone, particularly people with certain heart, blood vessel, liver, or blood-clotting conditions.

How Xulane Prevents Pregnancy

Xulane belongs to a group of medications called combined hormonal contraceptives. It contains both an estrogen and a progestin, which work together in several ways to reduce the chance of pregnancy.

Preventing Ovulation

The main way Xulane works is by preventing ovulation.

Ovulation occurs when an ovary releases an egg. If no egg is released, sperm cannot fertilize it, and pregnancy cannot occur.

The hormones in Xulane help suppress the natural hormonal signals that trigger the release of an egg.

Thickening Cervical Mucus

Xulane also causes the mucus around the cervix to become thicker.

The cervix is the opening between the vagina and the uterus. Thicker cervical mucus makes it more difficult for sperm to travel through the cervix and reach an egg.

Changing the Uterine Lining

The hormones in Xulane also change the lining of the uterus, known as the endometrium.

This makes the uterine lining thinner and less suitable for supporting a pregnancy. However, preventing ovulation is the primary way the patch works.

How the Patch Delivers Medication

Xulane is applied directly to the skin. The hormones pass through the skin and enter the bloodstream continuously while the patch is in place.

This provides a steady amount of medication throughout the week. The patch must remain firmly attached and be replaced on schedule for it to work effectively.

Typical Patch Schedule

Xulane is usually used in a four-week cycle:

  • One new patch is applied each week for three consecutive weeks
  • No patch is worn during the fourth week
  • A new four-week cycle begins after the patch-free week

Bleeding similar to a menstrual period often occurs during the patch-free week.

The patch should be changed on the same day each week. Following the schedule carefully helps maintain effective pregnancy prevention.

Effectiveness

Xulane is most effective when it is used correctly and consistently.

Its effectiveness may be reduced if:

  • A patch is applied late
  • A patch becomes loose or falls off
  • The patch-free interval lasts longer than directed
  • Certain medications reduce hormone levels
  • The patch is not used according to the prescribed schedule

A backup method of birth control, such as condoms, may be needed if the patch schedule is interrupted.

Body Weight Considerations

Xulane may be less effective in people who weigh 90 kg or more. It is also not recommended for certain people with a body mass index of 30 kg/m² or higher because of an increased risk of blood clots.

A healthcare provider will determine whether Xulane is an appropriate option based on body weight, body mass index, and other health factors.

Does Xulane Affect Menstrual Periods?

Xulane may make periods more regular, lighter, or less painful for some people. However, spotting or bleeding between periods may occur, especially during the first few months of use.

Some people may also experience:

  • Changes in menstrual flow
  • Breast tenderness
  • Headaches
  • Nausea
  • Skin irritation where the patch is applied
  • Mood changes

These effects may improve as the body adjusts to the hormones.

Does Xulane Protect Against Sexually Transmitted Infections?

No. Xulane does not protect against HIV, chlamydia, gonorrhoea, herpes, or other sexually transmitted infections.

Condoms can be used with Xulane to help reduce the risk of sexually transmitted infections.

Reversible Birth Control

Xulane is a reversible form of contraception. Fertility generally returns after the patch is stopped, although the timing may vary from person to person.

People who want to become pregnant should speak with their healthcare provider about when to stop using the patch and whether any pre-pregnancy care is recommended.

Important Safety Information

Combined hormonal contraceptives can increase the risk of serious blood clots, stroke, or heart attack in some people. The risk may be higher in people who smoke, are older than 35, have obesity, or have certain medical conditions.

Before starting Xulane, tell your healthcare provider about your complete medical history, especially any history of blood clots, migraine with aura, high blood pressure, heart disease, stroke, liver disease, breast cancer, or unexplained vaginal bleeding.

Xulane should be used exactly as prescribed. Do not change the patch schedule or continue using the medication if you think you may be pregnant without speaking with your healthcare provider.

Xulane is used to prevent pregnancy in people of reproductive age for whom a combined hormonal contraceptive is appropriate.

It primarily works by:

  • Preventing the ovaries from releasing an egg, known as ovulation
  • Thickening cervical mucus so sperm have more difficulty reaching an egg
  • Changing the uterine lining

Xulane does not protect against HIV or other sexually transmitted infections. Condoms may be used to help reduce the risk of these infections.

Xulane is intended for people with a body mass index, or BMI, below 30 kg/m². It should not be used by people with a BMI of 30 kg/m² or higher because the risk of blood clots may be increased. It may also be less effective in people who weigh 90 kg, or 198 pounds, or more.

Recommended Dosage and Schedule

Xulane is applied to the skin once weekly according to a four-week cycle.

Week 1: Apply one new patch.

Week 2: Remove the old patch and apply a new patch on the same day of the week.

Week 3: Remove the second patch and apply a third patch on the same day.

Week 4: Remove the third patch and do not wear a patch for seven days.

A new four-week cycle begins after the patch-free week. Apply a new patch on the same day of the week, even if menstrual bleeding has not stopped.

Only one Xulane patch should be worn at a time. Do not wear a patch for longer than seven days unless your healthcare provider gives you different instructions.

Where to Apply Xulane

Apply the patch to clean, dry, healthy skin on the:

  • Upper outer arm
  • Abdomen
  • Buttock
  • Upper torso or back

Do not apply Xulane to the breasts or to skin that is irritated, cut, oily, or covered with creams, powders, lotions, or makeup.

Press the patch firmly onto the skin and check it each day to make sure it remains fully attached.

Starting Xulane

Your healthcare provider may recommend starting Xulane on the first day of your menstrual period or on the first Sunday after your period begins.

Depending on when the first patch is applied and whether you are switching from another contraceptive, you may need to use a backup method, such as condoms, for the first seven days.

Follow the exact starting instructions provided by your healthcare provider or pharmacist.

If a Patch Falls Off or Is Applied Late

The instructions depend on how long the patch has been loose, detached, or overdue.

A replacement patch may be needed, and backup contraception may be required for seven days. Do not try to reattach a patch that is no longer sticky, has folded onto itself, or has become contaminated.

Contact your pharmacist or healthcare provider if you are unsure how long the patch has been detached or if your patch-free interval has lasted longer than seven days.

Common Side Effects of Xulane (norelgestromin/ethinyl estradiol transdermal system):

  • Breast tenderness, discomfort, or swelling
  • Headache or migraine
  • Nausea or vomiting
  • Menstrual cramps
  • Spotting or bleeding between periods
  • Changes in menstrual flow
  • Skin redness, itching, or irritation where the patch is applied
  • Mood changes
  • Abdominal pain
  • Weight changes

Serious Side Effects of Xulane (norelgestromin/ethinyl estradiol transdermal system):

  • Pain, swelling, warmth, or redness in one leg
  • Sudden shortness of breath
  • Sharp or severe chest pain
  • Coughing up blood
  • Sudden numbness or weakness, especially on one side
  • Difficulty speaking
  • A sudden, severe headache
  • Sudden partial or complete vision loss

Xulane (norelgestromin/ethinyl estradiol transdermal system) is available in the following forms and strength:

Norelgestromin/ethinyl estradiol transdermal system: Patch

  • 150/35 mcg

Xulane is a combined hormonal birth-control patch containing estrogen and progestin. It may not be suitable for everyone because these hormones can increase the risk of blood clots, stroke, heart attack, and other serious complications.

Before using Xulane, tell your healthcare provider about your complete medical history, current medications, smoking status, weight, and any previous problems with hormonal contraception.

Smoking and Age

Do not use Xulane if you are older than 35 and smoke cigarettes. Smoking while using a combined hormonal contraceptive significantly increases the risk of serious cardiovascular problems, including blood clots, heart attack, and stroke.

The risk increases with age and with the number of cigarettes smoked.

Body Mass Index and Body Weight

Xulane should not be used by people with a body mass index of 30 kg/m² or higher because the risk of blood clots may be greater.

The patch may also be less effective at preventing pregnancy in people who weigh 90 kg, or approximately 198 pounds, or more. A healthcare provider can help determine whether another contraceptive method would be safer or more reliable.

Blood Clots

Xulane may increase the risk of developing a serious blood clot in the legs or lungs. A clot may also lead to a stroke, heart attack, or sudden vision loss.

The risk may be higher if you:

  • Have previously had a blood clot
  • Have an inherited blood-clotting condition
  • Recently had major surgery
  • Must remain in bed or have limited movement for a long period
  • Have obesity
  • Smoke
  • Have recently given birth
  • Have certain heart or blood vessel conditions

Seek emergency medical attention if you develop pain or swelling in one leg, sudden shortness of breath, chest pain, coughing up blood, sudden weakness, difficulty speaking, or sudden vision changes.

Surgery or Prolonged Immobilization

Tell your surgeon that you use Xulane before any planned operation. Your healthcare provider may instruct you to stop using the patch before major surgery or during an extended period of limited movement to reduce the risk of blood clots.

Do not stop or restart Xulane without receiving specific medical instructions.

Heart and Blood Vessel Conditions

Xulane may not be appropriate if you have:

  • Coronary artery disease
  • A previous heart attack or stroke
  • Heart-valve problems associated with blood clots
  • Certain abnormal heart rhythms
  • Severe or uncontrolled high blood pressure
  • Diabetes that has damaged the blood vessels

Your blood pressure should be checked before starting Xulane and monitored during use. Contact your healthcare provider if you develop severe headaches, dizziness, blurred vision, or unusually high blood pressure readings.

Migraines and Severe Headaches

Tell your healthcare provider if you have migraines, especially migraines with aura. Aura may include flashing lights, blind spots, numbness, weakness, or difficulty speaking before or during a headache.

Xulane should generally not be used by people who experience migraine with aura because of the increased risk of stroke. Report any new, severe, frequent, or unusual headache promptly.

Pregnancy

Do not use Xulane if you are pregnant. Stop using the patch and contact your healthcare provider if you think you may be pregnant.

Xulane does not end an existing pregnancy and should not be used as emergency contraception.

Breastfeeding and After Childbirth

The hormones in Xulane may reduce breast-milk production, particularly when breastfeeding is first being established. Small amounts of the hormones may also pass into breast milk.

There is also an increased risk of blood clots during the weeks following childbirth. Ask your healthcare provider when it is safe to begin using Xulane after delivery and whether another contraceptive method would be more appropriate while breastfeeding.

Breast Cancer and Other Hormone-Sensitive Cancers

Do not use Xulane if you currently have breast cancer or another cancer that is sensitive to estrogen or progestin. Tell your healthcare provider about any personal or family history of breast cancer.

Report a new breast lump, nipple discharge, skin changes, or persistent breast pain.

Liver and Gallbladder Problems

Xulane may not be suitable for people with severe liver disease, liver tumours, or abnormal liver function.

Contact your healthcare provider if you develop yellow skin or eyes, dark urine, pale stools, severe upper abdominal pain, persistent nausea, or unusual tiredness.

Combined hormonal contraceptives may also increase the risk of gallbladder problems or worsen existing gallbladder disease.

Diabetes, Cholesterol, and Triglycerides

Xulane may affect blood sugar and blood-fat levels. Tell your healthcare provider if you have diabetes, high cholesterol, or high triglycerides.

People with diabetes may need closer blood sugar monitoring. Xulane may not be appropriate if diabetes has caused complications involving the kidneys, eyes, nerves, or blood vessels.

Unexplained Vaginal Bleeding

Tell your healthcare provider if you have vaginal bleeding that has not been evaluated. The cause of unexplained bleeding should be investigated before starting Xulane.

Spotting or breakthrough bleeding can occur during the first few months of use. Contact your provider if bleeding is very heavy, lasts a long time, repeatedly occurs after sex, or begins after previously regular cycles.

Mood Changes and Depression

Some people may experience mood changes or worsening depression while using hormonal contraception.

Tell your healthcare provider if you have a history of depression. Contact them if you develop persistent sadness, severe anxiety, unusual behavioural changes, or thoughts of self-harm.

Medication Interactions

Certain medications and herbal products can reduce Xulane’s effectiveness or increase the risk of side effects. These may include some treatments for:

  • Seizures
  • Tuberculosis
  • HIV or hepatitis C
  • Fungal infections
  • High blood pressure
  • Pulmonary hypertension

St. John’s wort may also make hormonal contraception less effective.

Tell your healthcare provider and pharmacist about all prescription medicines, non-prescription products, vitamins, and herbal supplements you use. A backup contraceptive method may be required during treatment and for a period after an interacting medication is stopped.

Xulane should not be used with certain hepatitis C treatment combinations containing ombitasvir, paritaprevir, and ritonavir, with or without dasabuvir, because of the risk of liver-enzyme elevations.

Skin Reactions and Patch Use

Apply Xulane only to clean, dry, healthy skin. Do not apply it to the breasts or to skin that is irritated, cut, oily, or covered with lotion, cream, powder, or makeup.

Do not cut, damage, or alter the patch, as this may reduce its contraceptive effectiveness. Check the patch daily to ensure that it remains fully attached.

Protection Against Sexually Transmitted Infections

Xulane does not protect against HIV or other sexually transmitted infections. Condoms may be used along with Xulane to help reduce the risk of infection.

When to Seek Emergency Medical Care

Seek immediate medical attention if you experience sudden chest pain, difficulty breathing, coughing up blood, pain or swelling in one leg, sudden weakness or numbness, difficulty speaking, a severe unusual headache, sudden vision loss, or swelling of the face, lips, tongue, or throat.

How Often Do I Change the Xulane Patch?

Apply one new patch each week for three consecutive weeks. During the fourth week, do not wear a patch. After the seven-day patch-free week, begin a new cycle by applying a fresh patch on your regular patch-change day. The patch-free interval should never last longer than seven days.

Where Can I Apply the Xulane Patch?

Apply Xulane to clean, dry, healthy skin on the upper outer arm, abdomen, buttock, upper torso, or back. Do not apply the patch to the breasts or to skin that is irritated, cut, oily, or covered with creams, lotions, powders, or makeup.

Can I Shower, Swim, or Exercise While Wearing Xulane?

Yes. The patch is designed to remain attached during normal activities such as showering, swimming, bathing, and exercising. Check the patch every day to make sure it remains fully attached. Avoid rubbing the patch or applying creams, oils, or lotions around it.

What Should I Do if My Patch Falls Off?

The instructions depend on how long the patch has been loose or detached. A replacement patch may be required, and you may need to use a backup birth-control method for seven days. Do not use tape or another adhesive to hold a loose patch in place. Contact your healthcare provider or pharmacist if you do not know how long the patch has been detached.

Can I Cut the Xulane Patch?

No. Do not cut, damage, or alter the patch. Changing its shape or size may affect how the hormones are released and may reduce its ability to prevent pregnancy.

How Effective Is Xulane?

Xulane can be highly effective when it is applied correctly and replaced on schedule. Its effectiveness may decrease if a patch is applied late, falls off, or the patch-free interval lasts longer than seven days. Xulane may also be less effective in people who weigh 90 kg, or approximately 198 pounds, or more.

Can People with a Higher BMI Use Xulane?

Xulane should not be used by people with a body mass index of 30 kg/m² or higher because the risk of serious blood clots may be increased. A healthcare provider can recommend a safer or more suitable contraceptive option.

Does Xulane Cause Weight Gain?

Some people may notice changes in their weight while using Xulane, but weight gain is not experienced by everyone. Diet, activity level, fluid retention, other medications, and health conditions can also affect body weight. Speak with your healthcare provider if you experience a significant or unexpected change.

Can Xulane Affect My Period?

Yes. Xulane may make menstrual periods more predictable, lighter, or less painful for some people. Spotting, breakthrough bleeding, or changes in menstrual flow may occur, especially during the first few months. Contact your healthcare provider if bleeding is very heavy, lasts a long time, or continues after several cycles.

Can I Skip My Period with Xulane?

Some healthcare providers may recommend using hormonal patches continuously to delay or skip bleeding. However, this is different from the standard Xulane schedule. Do not change or skip the patch-free week unless your healthcare provider gives you specific instructions. 

Does Xulane Protect Against Sexually Transmitted Infections?

No. Xulane does not protect against HIV, chlamydia, gonorrhoea, herpes, or other sexually transmitted infections. Condoms can be used with Xulane to help reduce the risk of sexually transmitted infections.

Can I Use Xulane While Breastfeeding?

The hormones in Xulane may reduce breast-milk production, particularly when breastfeeding is first being established. There is also an increased risk of blood clots shortly after childbirth. Speak with your healthcare provider about when it is safe to begin Xulane and whether another contraceptive method is more appropriate.

Can I Use Xulane if I Smoke?

People older than 35 who smoke should not use Xulane. Smoking while using a combined hormonal contraceptive increases the risk of blood clots, heart attack, stroke, and other serious cardiovascular problems. Tell your healthcare provider about your smoking or nicotine use before starting Xulane.

Can Xulane Interact with Other Medications?

Yes. Certain medications and herbal products may make Xulane less effective or increase the risk of side effects. These may include some medications used for seizures, tuberculosis, HIV, hepatitis C, fungal infections, and pulmonary hypertension. St. John’s wort may also reduce contraceptive effectiveness. Tell your healthcare provider about all prescription medications, non-prescription medicines, vitamins, and herbal supplements you use.

What Should I Do if I Forget to Change My Patch?

The correct instructions depend on which week of your cycle you are in and how late the patch change is. You may need to apply a new patch, begin a new four-week cycle, or use backup contraception for seven days. Contact your pharmacist or healthcare provider if you are unsure what to do.

When Should I Seek Emergency Medical Attention?

Seek immediate medical care if you experience possible signs of a blood clot, heart attack, or stroke, such as sudden chest pain, difficulty breathing, coughing up blood, pain or swelling in one leg, sudden weakness or numbness, difficulty speaking, a sudden severe headache, or sudden vision loss.

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Additional Information Book
Generic name:

norelgestromin/ethinyl estradiol transdermal system

Formulation:

Patch

Strength(s):

150/35mcg

Quantities Available:

3 patches

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Our online Canadian Pharmacy is known for high standards of quality, safety, and efficiency when it comes to medications.

Our pharmacy offers lower prices on prescription drugs compared to traditional pharmacies.

How to Order

How much Xulane can I order at once from a Canadian pharmacy?

When ordering Xulane (norelgestromin/ethinyl estradiol transdermal system) from a Canadian pharmacy, you can typically purchase up to a 90-day supply at one time, which is common for prescription medications to ensure adequate management of chronic conditions without frequent refills.

Here’s what you need to know:

Dosage and Quantity: Xulane is a patch with a strength of 150/35mcg used with a regimen of one patch per week for three weeks, followed by one patch-free week. For a 90-day supply, you would order 9 patches (3 patches per month x 3 months).

Do you sell norelgestromin/ethinyl estradiol transdermal system?

Yes, we sell norelgestromin/ethinyl estradiol transdermal system at our pharmacy, and you can enjoy low prices. However, to purchase the norelgestromin/ethinyl estradiol transdermal system, you will need a valid prescription from your healthcare provider. We require this to dispense the medication safely and appropriately. You can provide your prescription by mailing, faxing, or uploading it through your online account.

Do you offer shipping of Xulane (norelgestromin/ethinyl estradiol transdermal system) to the United States?

Yes, we ship Xulane (norelgestromin/ethinyl estradiol transdermal system) to both the United States and Puerto Rico.

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Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Xulane (norelgestromin/ethinyl estradiol transdermal system). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Xulane (norelgestromin/ethinyl estradiol transdermal system).