Vimovo (Naproxen/Esomeprazole Magnesium)

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Vimovo Brand
Dosage Quantity & Price
Naproxen/Esomeprazole Magnesium (Generic alternate to Vimovo) Generic

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Table of contents:

Vimovo is a prescription medication indicated to provide relief from the symptoms of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis while reducing the risk of stomach ulcers and other gastrointestinal problems in adult and adolescent patients 12 years of age and older weighing at least 38 kg.

Vimovo contains two active ingredients: Naproxen and Esomeprazole. Naproxen is a non-steroidal anti-inflammatory drug (NSAID) and works by reducing substances in the body that cause pain and inflammation. Esomeprazole is a proton pump inhibitor (PPI) that works by reducing the amount of acid produced in the stomach.

Uses and Dosage

Vimovo is an oral medication that comes in the form of Modified Release Tablets. It should be taken as directed by your doctor, usually twice daily (in the morning and evening) at least 30 minutes before a meal, with a full glass of water unless your doctor directs you otherwise. After taking the tablet, do not lie down for at least 10 minutes to avoid any potential side effects. The tablet should be swallowed whole - do not break, chew, crush or dissolve the tablet as this can destroy the slow release of the drug and increase side effects.

To achieve the maximum benefit from Vimovo, it should be used regularly at the same times eachday. It may take up to 2 weeks of taking the tablet until you experience the full effect. If your condition persists or worsens, inform your doctor as the risk of side effects increases over time. Consult with your doctor on the recommended duration for taking this medication.

Side effect

Common Side Effects of Vimovo (Naproxen/Esomeprazole Magnesium):

  • Stomach discomfort
  • Diarrhea

Serious Side Effects of Vimovo (Naproxen/Esomeprazole Magnesium):

  • Blood in your urine
  • Bloody or tarry stools
  • Chest pain spreading to your jaw or shoulder
  • Choking feeling
  • Cold hands and feet
  • Cough
  • Coughing up blood or vomit that looks like coffee grounds
  • Dark urine
  • Diarrhea that is watery or bloody
  • Dizziness
  • Fast or irregular heartrate
  • Feeling jittery
  • Jerking muscle movements
  • Joint pain
  • Lightheadedness
  • Little or no urination
  • Loss of appetite
  • Muscle spasms in your hands and feet
  • Pale skin
  • Rapid weight gain
  • Severe stomach pain
  • Shortness of breath
  • Skin rash on your cheeks or arms that worsens in sunlight
  • Slurred speech
  • Stomach pain (upper right side)
  • Sudden numbness or weakness on one side of the body
  • Swelling
  • Tremors
  • Unusual tiredness
  • Yellowing of the skin or eyes (jaundice)

Form and Strength

Vimovo (Naproxen/Esomeprazole Magnesium) is available in the following forms and strength:

Vimovo: Modified Release Tablets

  • 375/20 mg
  • 500/20 mg


  • Vimovo can increase the risk of heart attack, stroke, and blood clots, especially in patients who have a history of heart disease or stroke.
  • Vimovo can increase the risk of gastrointestinal (GI) bleeding and ulcers, which can be life-threatening, especially in patients who have a history of GI problems or are taking certain medications such as corticosteroids or blood thinners.
  • Vimovo should not be used by patients who are allergic to naproxen, esomeprazole, or any other ingredients in the medication.
  • Vimovo can cause kidney damage or make kidney problems worse, especially in patients who have pre-existing kidney disease.
  • Vimovo can affect liver function and should be used with caution in patients who have liver disease or liver problems.
  • Vimovo may interact with other medications, including blood thinners, aspirin, and diuretics, inform your healthcare provider of all medications and supplements you are taking.
  • Vimovo can cause serious skin reactions, including skin rash, blisters, and peeling, which can be life-threatening.
  • Vimovo can increase the risk of bone fractures, especially in patients who take high doses for an extended period of time.
  • Vimovo can interact with alcohol and should not be used with alcohol or in patients who have a history of alcohol abuse.
  • Vimovo should be used with caution in elderly patients, as they may be more susceptible to its side effects.
  • Vimovo can cause dizziness, drowsiness, and other neurological side effects, which can impair the patient's ability to perform tasks that require alertness.
  • Vimovo can interact with other medical conditions, including asthma, heart disease, and high blood pressure, so discuss all medical conditions with your healthcare provider before taking Vimovo.

Frequently Asked Questions (FAQ)

How long after eating can you take Vimovo?

Do not take Vimovo with food as this may reduce and/or delay the effect of VIMOVO. Take your tablets at least 30 minutes before you have a meal.

Is Vimovo addictive?

Vimovo is not known to be addictive, but it should be used with caution in patients with a history of substance abuse, as well as in patients with mental health conditions.

Does Vimovo cause weight gain?

Weight gain is not a common side effect of Vimovo. However, if you experience sudden or unexplained weight gain while taking Vimovo, you should consult your healthcare provider.

How long does it take for Vimovo to start working?

Vimovo can start working within a few hours, but it may take several days for the full benefits to be felt. Continue taking Vimovo as prescribed, even if you start feeling better.


It's important to purchase Vimovo from verified Canadian pharmacy.

Additional information

Generic name:

Naproxen/Esomeprazole Magnesium


Modified Release Tablets


375/20mg, 500/20mg

Quantities Available:

60, 180


Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Vimovo (Naproxen/Esomeprazole Magnesium). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Vimovo (Naproxen/Esomeprazole Magnesium).