Trental ER (Pentoxifylline)

Indications

Trental ER is an oral medication that improves the symptoms of a certain blood flow problem in the legs/arms (intermittent claudication due to occlusive artery disease). It comes in the form of extended-release tablets for oral administration.

The active drug in Trental ER is pentoxifylline, which is a hemorheologic agent used to improve blood flow through narrowed arteries. It works by helping blood flow more easily through narrowed arteries. It increases the amount of oxygen that can be delivered by the blood when the muscles need more (such as during exercise) thereby increasing walking distance and duration.

Use and Dosage

Trental comes in the form of ER tablet to take it orally with food as directed by your doctor, usually 3 times daily. Swallow the tablets whole. Do not crush or chew the tablets. Doing so can release all the drug at once, increasing the risk of side effects.

The recommended dosage for Trental ER (extended release) is typically 400 mg by mouth three times a day with meals. The treatment is usually continued for at least 8 weeks. However, note that dosages may vary depending on the individual and their medical history. Consult with a healthcare provider to determine the appropriate dosage for a particular patient.

Take Trental ER regularly to maximize its benefits. Take it at regular times each day to assist with remembering. Don't discontinue use of the tablet without first consulting with your doctor, even if you feel better. While symptom improvements may be evident within 2-4 weeks, it could take as long as 8 weeks to experience the medications full benefits.

Side Effects

Common Side Effects of Trental ER (Pentoxifylline):

Common side effects of Trental include:

• Belching
• Bloating
• Blurred vision
• Diarrhea
• Dizziness
• Flushing (warmth, redness, or tingly feeling)
• Gas
• Headache
• Nausea
• Upset stomach
• Vomiting

Serious Side Effects of Trental ER (Pentoxifylline):

• Bloody or tarry stool
• Chest pain
• Coughing up blood or vomit
• Easy bruising or bleeding
• Fast or irregular heartbeat
• Feeling like you might pass out
• Red or pink urine

Forms and Strength

Trental ER (Pentoxifylline) is available in the following forms and strength:

Trental ER: ER Tablet

• 400 mg

Cautions

• Trental ER can interact with other medications and has warnings for people who take blood thinning medications. Trental ER should be used with caution in patients with severe renal or hepatic impairment.
• People with a history of recent cerebral and/or retinal hemorrhage should be monitored closely while taking Trental ER.
• Trental ER should be used with caution in patients with uncontrolled hypertension or history of angina pectoris.
• Trental ER should not be used in patients who have shown hypersensitivity to any of its components.
• Trental ER should not be used during pregnancy unless clearly needed.
• Trental ER should not be used by nursing mothers because it may pass into breast milk and cause harm to a nursing infant.
• Trental ER should be used with caution in patients with bleeding disorders or those at risk of bleeding, as it may increase bleeding time.
• Trental ER may cause dizziness or blurred vision, which may impair the ability to drive or operate machinery. Patients should be advised to avoid such activities if they experience these side effects.
• Trental ER may interact with medications used to treat diabetes, so patients on these medications should be monitored closely for potential interactions.
• Trental ER may increase the risk of seizures in patients with a history of seizures or epilepsy. Therefore, it should be used with caution in these patients.
• Trental ER may cause gastrointestinal upset such as nausea and vomiting, so patients with a history of gastrointestinal ulcers or bleeding should use it with caution.
• Trental ER should not be used in patients with severe coronary artery disease or recent myocardial infarction.
• Trental ER may cause an increase in heart rate and decrease in blood pressure, especially in elderly patients. Hence, it should be used with caution in elderly patients.
• Trental ER should not be used in patients under 18 years of age as its safety and efficacy have not been established in the population.

Frequently Asked Questions (FAQ)

How long does it take for Trental ER to start working?

The time it takes for Trental ER to start working varies depending on the individual, but it typically takes several weeks to see significant improvement in symptoms.

Can Trental ER be used to prevent strokes?

There is limited evidence to support the use of Trental ER for stroke prevention. It is primarily used to improve circulation in peripheral vascular disease.

Can Trental ER be used for tinnitus?

Trental ER has been used to treat tinnitus (ringing in the ears), but there is limited evidence of its effectiveness for this condition.

How should Trental ER be stored?

Trental ER should be stored at room temperature, away from heat and moisture. It should be kept out of the reach of children.

What should I do if I miss a dose of Trental ER?

If you miss a dose of Trental ER, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double dose.

Resources

• https://www.drugs.com/drug-interactions/pentoxifylline.html
• https://www.rxlist.com/trental-drug.htm
• https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/018631s041lbl.pdf
• https://www.webmd.com/drugs/2/drug-5022/pentoxifylline-oral/details
• https://healthy.kaiserpermanente.org/health-wellness/drug-encyclopedia/drug.pentoxifylline-er-400-mg-tablet-extended-release.208837
• https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/018631s041lbl.pdf
• https://www.goodrx.com/pentoxifylline/what-is