Tofranil (Imipramine)

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Tofranil Brand
Dosage Quantity & Price
Imipramine (Generic alternate to Tofranil) Generic
Dosage Quantity & Price
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Table of contents:

Tofranil is an oral medication primarily used to treat depression. Imipramine belongs to a class of drugs called tricyclic antidepressants. Imipramine works by increasing the levels of certain natural chemicals, such as serotonin and norepinephrine, in the brain to improve and stabilize mood.

Using Tofranil to treat depression may improve your mood, sleep, appetite, and energy level and may help restore your interest in daily living. In addition, Tofranil can be used to treat other conditions such as ADHD (attention deficit hyperactivity disorder), anxiety, and bedwetting in children.

Uses and Dosage

Tofranil (Imipramine) tablets are usually taken by mouth with or without food as directed by your doctor, usually 1 to 4 times daily. If you experience daytime drowsiness, your doctor may advise you to take the entire dose once daily at bedtime.

The dose you need will depend on your medical condition and response to therapy. If you are a child, the dosage may be based on your body weight. To minimize your risk of side effects, your doctor may start you at a low dose and then gradually increase your dose.

If you are using imipramine to manage bed-wetting in children, it should be taken one hour before bedtime. In case your child typically wets the bed early in the night, the drug can be given earlier in separate doses. For example, the drug may be given in one dose in the afternoon and another one at bedtime.

If you are taking imipramine for depression, you should be aware that it does not start working immediately. It may take up to 3 weeks before you experience the full benefits of the medication. Continue taking the medication even if you start feeling better. Do not stop taking the tablet suddenly without first consulting your doctor. Suddenly stopping medication may worsen some conditions. Your doctor may need to decrease your dose gradually.

Side effect

Common Side Effects of Tofranil (Imipramine):

  • Breast welling (both men and women)
  • Constipation
  • Decreased sex drive
  • Diarrhea
  • Difficulty having an orgasm
  • Dry mouth
  • Impotence
  • Lack of coordination
  • Nausea
  • Ringing in your ears
  • Tingly feeling
  • Vision changes
  • Vomiting
  • Weakness

Serious Side Effects of Tofranil (Imipramine):

  • Aggression
  • Agitation
  • Anxiety
  • Blurred vision
  • Confusion
  • Eye pain or swelling
  • Fever
  • Fluttering in your chest
  • Hallucinations
  • Hostility
  • Hyperactivity (mentally or physically)
  • Impulsive behavior
  • Irritableness
  • lightheadedness
  • Mood or behavior changes
  • More depression
  • New or worsening chest pain
  • Painful or difficult urination
  • Panic attacks
  • Pounding heartbeats
  • Problems with vision speech or balance
  • Restlessness
  • Seeing halos around lights
  • Seizures and
  • Sore throat
  • Sudden numbness or weakness
  • Suicidal thoughts
  • Trouble sleeping
  • Tunnel vision
  • Unusual thoughts or behavior
  • Yellowing of the skin or eyes (jaundice)

Form and Strength

Tofranil (Imipramine) is available in the following forms and strength:

Tofranil: Coated Tablet

  • 25 mg

Imipramine: Coated Tablet

  • 10 mg
  • 25 mg
  • 50 mg
  • 75 mg


  • Caution should be exercised when using imipramine hydrochloride with agents that lower blood pressure.
  • Imipramine may cause drowsiness or dizziness, which may impair the ability to perform tasks that require alertness. Caution should be exercised when driving or operating machinery.
  • Tofranil may increase the risk of suicidal thinking and behavior, especially in children, teenagers, and young adults. Close monitoring by a healthcare provider is necessary.
  • Imipramine may interact with other medications, including monoamine oxidase inhibitors (MAOIs), alcohol, and certain antihistamines and anticholinergics. Talk to a healthcare provider about all medications, supplements, and herbal products currently being taken before using imipramine.
  • Tofranil may increase the risk of seizures, especially in individuals with a history of seizures or other risk factors. Close monitoring by a healthcare provider is necessary.
  • Imipramine should be used with caution in individuals with a history of heart disease, liver or kidney problems, glaucoma, or urinary retention.
  • Tofranil may cause a prolonged or painful erection in men (priapism). Seek medical attention immediately if this occurs.
  • Imipramine may cause weight gain, changes in appetite, and fluid retention. Individuals with a history of diabetes or heart disease should be closely monitored for these side effects.
  • Tofranil may increase the risk of glaucoma, a condition characterized by increased pressure in the eyes. Close monitoring by an eye doctor is necessary.
  • Imipramine should be used with caution in individuals with a history of bipolar disorder, as it may increase the risk of mania or hypomania.
  • Tofranil should not be used during pregnancy or while breastfeeding due to potential risks to the fetus or infant.

Frequently Asked Questions (FAQ)

How long does it take for Tofranil (Imipramine) to start working?

It can take several weeks of treatment for Tofranil (Imipramine) to begin working fully. Patients should speak to their healthcare provider about any concerns or lack of improvement after a few weeks of taking the medication.

Can Tofranil (Imipramine) be addictive?

While Tofranil (Imipramine) is not addictive in the same way as drugs like opioids, gradually reduce the dosage of the medication under the supervision of a healthcare provider when discontinuing the medication to minimize the risk of withdrawal symptoms.

Can Tofranil (Imipramine) be used to treat other conditions besides depression?

Yes, Tofranil (Imipramine) may also be used to treat other conditions such as anxiety, ADHD, and bedwetting in children. However, it should only be used as prescribed by a healthcare provider.

What should I do if I miss a dose of Tofranil (Imipramine)?

If you miss a dose of Tofranil (Imipramine), take it as soon as you remember. However, if it is close to the time of your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.


It's important to purchase Tofranil from verified Canadian pharmacy.

Additional information

Generic name:



Coated Tablet, Tablet


10mg, 25mg, 50mg, 75mg

Quantities Available:

100, 200