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Tofranil contains the active ingredient imipramine hydrochloride. It is a prescription medication used to relieve symptoms of depression and, in certain children, to help manage nighttime bedwetting.
Tofranil is used to relieve symptoms of depression.
Depression can affect mood, sleep, energy, concentration, appetite, motivation, and interest in everyday activities. Imipramine may help improve these symptoms by changing the activity of certain chemical messengers in the brain.
The full antidepressant effect does not usually occur immediately. It may take about 1 to 3 weeks or longer before the optimal therapeutic effect becomes noticeable.
The safety and effectiveness of imipramine for treating depression in children and adolescents have not been established. Pediatric use is specifically established for nocturnal enuresis rather than depression.
Tofranil may also be used as a temporary additional treatment for nocturnal enuresis, commonly known as nighttime bedwetting, in children 6 years of age and older.
Before treatment begins, a healthcare provider should make sure the bedwetting is not being caused by another medical condition.
Tofranil may reduce the number of nighttime bedwetting episodes in some children. However, its effectiveness may decrease with continued treatment, and it is generally not intended as a permanent treatment for bedwetting.
Tofranil belongs to a class of medications called tricyclic antidepressants (TCAs).
Its antidepressant effect is thought to be related mainly to its ability to reduce the reuptake of norepinephrine and, to a lesser extent, serotonin in the brain. This increases the availability of these chemical messengers between nerve cells and may help improve symptoms of depression.
The exact mechanism by which imipramine reduces nighttime bedwetting is not fully understood and appears to be different from its antidepressant action.
Tofranil may be considered when a healthcare provider determines that a tricyclic antidepressant is appropriate.
Treatment is individualized based on symptoms, medical history, other medications, response to treatment, and the risk of side effects. Because imipramine can affect the heart and nervous system, careful dosing and monitoring may be needed.
For children with nighttime bedwetting, Tofranil is generally used as a temporary treatment after other possible causes have been evaluated.
Treatment may be combined with behavioral approaches such as regular bathroom routines and limiting excessive fluid intake close to bedtime.
The healthcare provider may periodically review whether continued treatment is necessary and may recommend a medication-free period after a successful course of therapy.
Tofranil tablets are taken by mouth exactly as prescribed by your healthcare provider.
For depression, the total daily dose may be divided into several doses. In some patients, the dose may later be adjusted to a once-daily schedule, depending on response and side effects. Your healthcare provider will determine the most appropriate schedule for you.
Tofranil treatment for depression usually begins with a lower dose that is increased gradually.
For adults treated as outpatients, the usual starting dose is 75 mg per day, which may be increased to 150 mg per day if needed. Doses above 200 mg per day are generally not recommended for outpatients.
Hospitalized patients may require higher doses under close medical supervision.
Once symptoms improve, your healthcare provider may reduce the dose to the lowest amount needed to maintain the improvement.
The usual maintenance dose for adults is 50 to 150 mg per day.
Lower starting doses are generally recommended for older adults and adolescents.
A typical starting dose is 30 to 40 mg per day, and it is usually not necessary to exceed 100 mg per day.
Tofranil does not work immediately.
When used for depression, it may take several weeks before you notice the full benefit. Continue taking the medication as prescribed even if you do not notice improvement right away.
Do not increase your dose on your own.
When Tofranil is prescribed for nocturnal enuresis in children 6 years of age and older, the usual starting dose is 25 mg once daily, taken about 1 hour before bedtime.
If the response is not adequate after about one week, the healthcare provider may increase the dose to:
A daily dose above 75 mg does not improve effectiveness and may increase side effects. The total dose should not exceed 2.5 mg/kg per day.
Some children tend to wet the bed early in the night.
In these cases, the healthcare provider may divide the dose, such as giving part of the medication in the midafternoon and the rest at bedtime. Do not change the timing or dose unless instructed by the healthcare provider.
Do not stop taking Tofranil suddenly unless your healthcare provider tells you to do so.
The dose is generally reduced gradually when treatment is discontinued. Gradual dose reduction may help reduce withdrawal symptoms and, in children treated for bedwetting, may also reduce the chance of relapse.
Take Tofranil at the same times each day and follow the dosing schedule provided by your healthcare provider.
Do not take more medication or take it more often than prescribed. If you experience excessive drowsiness or other troublesome side effects, contact your healthcare provider rather than changing the dose yourself.
Tofranil (Imipramine) is available in the following forms and strength:
Tofranil may increase the risk of suicidal thoughts or behavior in some people, particularly children, teenagers, and young adults during the early stages of antidepressant treatment or after a dose change.
Patients, family members, and caregivers should watch for worsening depression, unusual changes in behavior, agitation, anxiety, irritability, or thoughts of self-harm. Contact a healthcare provider promptly if these symptoms appear or become worse.
Tofranil may cause drowsiness, dizziness, or reduced alertness.
Use caution when driving, operating machinery, or performing activities that require concentration until you know how the medication affects you.
Alcohol may increase drowsiness and other central nervous system effects and should be limited or avoided as directed by your healthcare provider.
Tofranil can affect heart rate, heart rhythm, and blood pressure.
Use extra caution if you have heart disease, an abnormal heart rhythm, heart failure, or a history of cardiovascular problems. Imipramine may cause conduction abnormalities, rapid heartbeat, or a drop in blood pressure when standing.
Your healthcare provider may recommend heart monitoring, including an ECG, particularly if you have cardiovascular disease or require higher doses.
Tofranil can lower the seizure threshold and may increase the chance of having a seizure.
Tell your healthcare provider if you have epilepsy, a history of seizures, or another condition that may increase seizure risk.
Tofranil can cause mild widening of the pupils and may trigger an attack of angle-closure glaucoma in people who have anatomically narrow drainage angles in the eyes.
Tell your healthcare provider if you have glaucoma, eye pressure problems, eye pain, or changes in vision. Seek prompt medical attention for sudden eye pain, redness, blurred vision, or seeing halos around lights.
Because imipramine has anticholinergic effects, it can make urination more difficult.
Tell your healthcare provider if you have a history of urinary retention, an enlarged prostate, or difficulty emptying your bladder.
Tell your healthcare provider if you or a close family member has a history of bipolar disorder, mania, or hypomania.
Antidepressants such as Tofranil may trigger a manic or hypomanic episode in susceptible patients. Screening for bipolar disorder is recommended before antidepressant treatment begins.
Tofranil can interact with several medications.
Do not take Tofranil together with a monoamine oxidase inhibitor (MAOI). A minimum interval of 14 days is generally required when switching from an MAOI to imipramine because the combination can cause severe or potentially life-threatening reactions.
Other important interactions may occur with:
Tell your healthcare provider about all prescription medications, over-the-counter products, vitamins, supplements, and herbal products you use.
Tell your healthcare provider if you have liver or kidney disease.
These conditions may affect how your body handles imipramine and may increase the risk of side effects. Your healthcare provider may need to adjust your treatment or monitor you more closely.
Use Tofranil cautiously if you have an overactive thyroid or take thyroid medication.
Imipramine may increase the risk of cardiovascular side effects in these patients.
Tofranil may cause changes in appetite or weight in some patients.
Fluid retention and swelling may also occur. Tell your healthcare provider if you notice significant or unexplained weight changes, swelling, or worsening heart-related symptoms.
Tell your healthcare provider if you are pregnant, think you may be pregnant, or plan to become pregnant.
The effects of imipramine during pregnancy are not fully established. Tofranil should generally be used during pregnancy only when the potential benefit justifies the possible risk to the fetus.
Tell your healthcare provider if you are breastfeeding or plan to breastfeed.
Your healthcare provider should consider the potential benefits and risks of imipramine treatment while breastfeeding and determine whether treatment is appropriate for you.
Tell your surgeon, dentist, or anesthesiologist that you take Tofranil before having surgery or a medical procedure.
Imipramine can interact with medications used during anesthesia, so your healthcare team may need to adjust your treatment plan.
Do not take Tofranil if you have had a serious allergic reaction to imipramine or closely related tricyclic antidepressants.
Seek urgent medical attention if you develop swelling of the face, lips, tongue, or throat, severe rash, or difficulty breathing.
Tofranil does not usually work immediately. When it is used to treat depression, some symptoms may begin to improve within a few weeks, but it can take several weeks to experience the full benefit. Continue taking Tofranil as prescribed, even if you do not notice improvement right away. Contact your healthcare provider if your symptoms do not improve or become worse.
Tofranil is not considered addictive in the same way as opioids or other habit-forming drugs. However, your body can become accustomed to the medication. Stopping Tofranil suddenly may cause withdrawal-like symptoms such as nausea, headache, tiredness, or sleep problems. Your healthcare provider may gradually reduce your dose when treatment is discontinued.
Yes. Tofranil is also approved for the temporary management of nighttime bedwetting (nocturnal enuresis) in children 6 years of age and older, after other possible medical causes have been ruled out. Imipramine has also been used off-label for certain other conditions, but these uses are not the same as its approved indications. It should only be used for another condition when prescribed and monitored by a healthcare provider.
If you miss a dose of Tofranil, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take two doses at the same time or take extra medication to make up for the missed dose.
| Generic name: | Imipramine |
|---|---|
| Formulation: | Coated Tablet, Tablet |
| Strength(s): | 10mg, 25mg, 50mg, 75mg |
| Quantities Available: | 100 |
Our online Canadian Pharmacy is known for high standards of quality, safety, and efficiency when it comes to medications.
Our pharmacy offers lower prices on prescription drugs compared to traditional pharmacies.
When ordering Tofranil (imipramine) from a Canadian pharmacy, you can typically purchase up to a 90-day supply at one time, which is common for prescription medications to ensure adequate management of chronic conditions without frequent refills.
Here’s what you need to know:
Dosage and Quantity: Tofranil is commonly prescribed in dosages of 25 mg, taken once daily or in divided doses. For a 90-day supply at a maximum dosage of 300 mg per day, you would typically order 1,080 tablets (90 days x 12 tablets per day).
Yes, we sell imipramine on our website. You can enjoy low prices when you order through us. To purchase imipramine, you will need a valid prescription from your healthcare provider. We require this prescription to dispense the medication safely and appropriately. You have the option to submit your prescription by mailing it to us, faxing it, or uploading it through your online account.
Yes, we ship Tofranil (imipramine) to both the United States and Puerto Rico.
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Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Tofranil (Imipramine). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Tofranil (Imipramine).
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