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Rapamune, generically known as Sirolimus, is a prescription medication used as an immunosuppressive agent to prevent organ transplant rejection. Sirolimus works by blocking the activity of a protein called mammalian target of rapamycin (mTOR), which plays a key role in cell growth and proliferation. By inhibiting mTOR, sirolimus helps to reduce the number of immune cells that attack the transplanted organ, minimizing the risk of rejection. It is also indicated to treat a certain lung disease called lymphangioleiomyomatosis or LAM.
Uses and Dosage
Rapamune (Sirolimus) is available in tablet form and is typically taken orally once a day. You should decide whether to take Rapamune with or without a meal, and always follow this regimen for every dose. It is important to swallow the medication whole, and then drink a glass of water. Do not divide, crush, or chew the medication, as this is not recommended.
To achieve optimum results, take Rapamune regularly according to the prescribed dosing schedule. If you are also taking cyclosporine, make sure to take it 4 hours after Rapamune, as taking these medications at the same time could increase the levels of active ingredients in the system and potentially cause kidney problems.
Be sure not to change or adjust your Rapamune dosage, as it is determined based on several factors such as your weight, medical condition, laboratory test results, and response to treatment. It is also important not to stop taking Rapamune abruptly without first consulting your doctor to avoid any adverse effects or complications.
Common Side Effects of Rapamune (Sirolimus):
- Insomnia or trouble sleeping
- Joint pain
Serious Side Effects of Rapamune (Sirolimus):
- Bone pain
- Change in urine output
- Chest pain
- Dark urine
- Frequent urination
- Hearing problems
- Increased thirst
- Infection symptoms (fever, chills, persistent sore throat)
- Mental or mood changes
- Muscle cramps
- Persistent nausea and vomiting
- Serious brain infection
- Swelling abdomen
- Swelling of the extremities
- Unusual tiredness
- Yellowish eyes and skin
Form and strength
Rapamune (Sirolimus) is available in the following forms and strength:
- 1 mg
- 1 mg
- 2 mg
- Avoid taking Rapamune if you have had a liver or lung transplant without prior consultation with your doctor. Rapamune can increase the risk of infections and the development of lymphoma.
- If you are prescribed cyclosporine along with Rapamune, take it at least 4 hours after Rapamune.
- Do not alter the dosage of Rapamune without the advice of your doctor.
- Rapamune is a strong medicine that should only be taken as prescribed by your doctor.
- Some of the possible side effects of Rapamune include nausea, diarrhea, headache, chest pain, dizziness, and acne.
- Talk to your doctor before taking Rapamune if you have a history of high cholesterol or triglycerides, as this medication can have an impact on lipid levels.
- If you experience any serious side effects while taking Rapamune, such as difficulty breathing, chest pain, or severe allergic reactions, seek medical attention immediately.
- Rapamune may interact with other medications, so always inform your doctor about any other drugs you are using.
- If you are pregnant or planning to become pregnant, talk to your doctor about the potential risks and benefits of taking Rapamune.
Frequently Asked Questions (FAQ)
Is sirolimus the same as Rapamune?
Yes, sirolimus (Rapamune) and rapamycin are different names for the same medication. Scientists originally discovered the medication from a soil sample in Easter Island and named it rapamycin.
Can I take Rapamune during pregnancy?
Rapamune is not recommended for use during pregnancy unless the potential benefits outweigh the risks to the fetus.
Does Rapamune interact with other medications?
Yes, there are certain medications that can interact with Rapamune and cause serious side effects. You should always inform your doctor of all medications you are taking before starting Rapamune.
How long should I take Rapamune?
This medication is usually taken for 12 months or more, depending on your condition.
Does Rapamune cause seizures?
Seizures while taking this drug are rare. Thus, it must be reported immediately.
It's important to purchase Rapamune from verified Canadian pharmacy.