Prevalite (Cholestyramine)

Indications

Prevalite is a prescription medication primarily used as an adjunctive therapy to diet for the reduction of elevated serum cholesterol levels in people with high cholesterol. Lowering cholesterol helps decrease the risk for strokes and heart attacks.

Prevalite contains cholestyramine as its active ingredient. Cholestyramine belongs to a class of drugs called bile acid sequestrants. It works by binding to bile acids in the intestines and preventing them from being reabsorbed into the body. This causes the liver to produce more bile acid, which reduces the cholesterol in the blood.

Cholestyramine may also be used to treat itching caused by bile duct blockage. In addition to a proper diet (such as a low cholesterol/low-fat diet), other lifestyle changes that may help Cholestyramine work better include exercising, losing weight if overweight, and stopping smoking.

Uses and Dosage

Prevalite comes as a powder with doses measured by the scoopful (using the provided scoop) or in individual dose packets. Take powder by mouth as directed by your doctor, usually 1 to 2 times a day. The dosage is based on your medical condition and response to treatment. Do not take more than the recommended dose or stop taking the medication without first consulting your doctor.

Do not take your dose in the dry powder form. Measure out the prescribed dose of powder using the scoop provided with your medication. Mix the powder in at least 2 to 6 ounces (60 to 180 milliliters) of liquid (such as water, milk, fruit juice), stir completely, and drink right away. Rinse your glass with more liquid and drink the rinse liquid to be sure that you have taken the entire dose. You may also mix this medication with watery soups, applesauce, or a pulpy fruit which has a lot of juice (such as crushed pineapple, peaches).

Do not hold the mixture in your mouth for long since doing so can damage your teeth. Practice good dental habits (such as brushing and flossing your teeth regularly). To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor's instructions carefully. It may take several weeks before you get the full benefit of this drug.

Cholestyramine may decrease your absorption of other medications. Take your other medications as directed by your doctor, usually at least 1 hour before or 4 to 6 hours after cholestyramine. Ask your doctor or pharmacist for more information or if you have any questions.

Side Effect

Common Side Effects of Prevalite (Cholestyramine):

• Abdominal discomfort and/or pain
• Belching
• Bleeding tendencies due to hypoprothrombinemia (vitamin k deficiency) as well as vitamin a and d deficiencies
• Constipation
• Diarrhea
• Excess fat in feces (pale color, bulky, foul smelling)
• Gas
• Hyperchloremic acidosis in children
• Loss of appetite
• Nausea
• Osteoporosis
• Rash and irritation of the skin, tongue, and perianal area
• Vomiting

Serious Side Effects of Prevalite (Cholestyramine):

• Allergic reaction
• Bloody, black, or tarry stools
• Easy bruising or unusual bleeding
• Severe constipation
• Severe stomach pain

Form and Strength

Prevalite (Cholestyramine) is available in the following forms and strength:

Prevalite: Powder

• 4g

Caution

• Prevalite may interact with other medications or supplements, so inform a healthcare provider of all medications and supplements being taken. It can also interfere with the absorption of certain vitamins and minerals, so monitor nutrient intake and potentially take supplements as needed.
• Prevalite should not be taken by individuals with a rare genetic condition called phenylketonuria.
• Prevalite should be used with caution in individuals with liver and kidney disease.
• Prevalite may interact with warfarin, a blood-thinning medication, and may increase the risk of bleeding.
• Do not take your dose in the dry powder form. It should be taken with a full glass of water to prevent choking or intestinal blockage.
• Prevalite may interfere with the absorption of certain medications, so stagger the intake of other medications by several hours.
• Prevalite should not be taken by individuals with a history of bowel obstruction or exisiting gastrointestinal disorders.

Frequently Asked Questions (FAQ)

When is the best time to take Prevalite?

You should take this medication at mealtime. Make sure you also space out your other medications by at least 1 hour before or 4 to 6 hours after you take cholestyramine (Prevalite) to avoid any potential absorption issues.

How many times a day should you take cholestyramine?

You can take individual doses 1 to 6 times per day. You shouldn't take more than 6 pouches or level scoopfuls per day. Cholestyramine light: The starting dose is 1 pouch (4 grams) or 1 level scoopful (4 grams) taken by mouth once or twice per day.

Does Prevalite work for everyone?

Prevalite works differently for everyone and may not be effective in some people. If you are taking Prevalite for high cholesterol, make sure to follow your doctor's instructions on diet and exercise as well.

Is Prevalite safe for children to take?

Prevalite is considered safe for children to take, but the dosage may be adjusted based on their age and weight. Follow your doctor's instructions on dosage and administration.

Resources

• https://www.rxlist.com/prevalite-side-effects-drug-center.htm
• https://www.drugs.com/mtm/prevalite.html
• https://www.goodrx.com/cholestyramine/what-is
• https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=dd434ef8-8af3-434c-a0a0-9a0b18459ba0
• https://www.webmd.com/drugs/2/drug-5027/prevalite-oral/details