Table of contents:
Indications
Prestalia is a combination medication used to treat high blood pressure. It can be used as a first-line treatment for hypertension and for patients whose blood pressure is not adequately controlled on monotherapy. Prestalia contains two active ingredients, perindopril, and amlodipine, that work together to lower blood pressure.
Perindopril is an ACE (Angiotensin Converting Enzyme) inhibitor that works by reducing the production of a hormone that narrows blood vessels and increases blood pressure. Amlodipine is a calcium channel blocker that works by relaxing blood vessels and allowing more blood to flow through them, also decreasing the workload on the heart. By combining these two medications, Prestalia is able to effectively lower blood pressure in individuals with hypertension.
Use and Dosage
Prestalia is taken orally in tablet form, usually once daily, with or without food as directed by your doctor. To minimize the risk of side effects, your doctor may prescribe a low starting dose and gradually increase it.
The recommended starting dose for Prestalia is 3.5/2.5 mg per day, taken orally as a single tablet. Dosage should be adjusted based on individual blood pressure goals and may be increased gradually over time. The maximum recommended dose is 14/10 mg per day. Follow your doctor's instructions carefully regarding dosage and frequency of use.
Follow your doctor's instructions carefully and take your medication regularly to get the most benefit. Continue taking Prestalia even if you feel well, as most people with high blood pressure do not experience symptoms. It may take up to two weeks for the medication to reach its full effect. If your condition does not improve or worsens, consult your doctor, as your blood pressure may remain high or increase.
Side Effects
Common Side Effects of Prestalia (Perindopril Arginine/Amlodipine):
- Cough
- Diarrhea
- Dizziness
- Headache
- Elevated levels of potassium in the blood (hyperkalemia)
- Itching
- Muscle cramps
- Nausea
- Rash
- Sexual dysfunction
- Shortness of breath
- Swelling of the legs and feet
- Weakness
Serious Side Effects of Prestalia (Perindopril Arginine/Amlodipine):
- Change in the amount of urine
- Chest pain
- Chest, jaw, and left arm pain
- Dark urine
- Difficulty breathing
- Fainting,
- Fast, irregular, and pounding heartbeat
- Hives
- Loss of appetite
- Muscle weakness
- Nausea
- Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights
- Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheadedness, or passing out
- Severe dizziness
- Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors
- Shortness of breath
- Slow or irregular heartbeat
- Stomach pain
- Swelling of your face, lips, tongue, or throat
- Unusual sweating
- Vomiting
- Yellowing of the eyes or skin (jaundice)
Forms and Strength
Prestalia (Perindopril Arginine/Amlodipine) is available in the following forms and strength:
Prestalia: Tablet
- 3.5/2.5mg
- 7/5mg
- 14/10mg
Cautions
- Discontinue the medication as soon as possible if signs or symptoms of angioedema occur.
- Patients with a history of angioedema unrelated to ACE inhibitors or angiotensin II receptor antagonists may be at an increased risk of angioedema when using Prestalia.
- The medication may cause symptomatic hypotension, especially in patients who are volume-depleted or who have severe congestive heart failure.
- Renal function should be monitored when starting the medication and periodically thereafter.
- Patients with severe hepatic impairment should not use Prestalia.
- Patients taking Prestalia should avoid excess alcohol consumption.
- Patients with aortic or mitral valve stenosis, obstructive hypertrophic cardiomyopathy, or severe obstructive coronary artery disease should not use Prestalia.
- Patients with a history of bronchial asthma, chronic obstructive pulmonary disease (COPD), or other obstructive airway diseases may be at increased risk of developing cough or difficulty breathing when using Prestalia.
- Hypersensitivity reactions, including anaphylactoid reactions and angioedema, have been reported with the use of some ACE inhibitors and may occur with Prestalia.
- Patients with a history of hypotension or those taking medications that lower blood pressure may be at an increased risk of symptomatic hypotension when using Prestalia.
- Use caution when driving or operating heavy machinery, as Prestalia may cause dizziness or drowsiness.
- Patients with a history of liver disease or impaired liver function may be at an increased risk of developing liver problems when using Prestalia.
- The safety and effectiveness of Prestalia in children have not been established.
- Prestalia should be used with caution in patients with diabetes, as it may affect blood sugar control.
- The medication may interact with other medications, such as potassium-sparing diuretics, potassium supplements, and nonsteroidal anti-inflammatory drugs (NSAIDs), and patients should discuss all medications they are taking with their healthcare provider before starting to use Prestalia.
Frequently Asked Questions (FAQ)
Can Prestalia be taken during pregnancy?
No, Prestalia should not be taken during pregnancy as it may cause harm to the fetus.
What should I do if I miss a dose of Prestalia?
If you miss a dose of Prestalia, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and take the next dose at the regular time. Do not take a double dose to make up for a missed one.
How long does it take for Prestalia to start working?
Prestalia may start to lower blood pressure within a few hours of taking the first dose, but it may take several weeks for the full effect to be seen.
Can Prestalia be taken with food?
Yes, Prestalia can be taken with or without food.
Can Prestalia be taken at night?
Yes, Prestalia can be taken at any time of day, but it is usually taken in the morning
Resources
It's important to purchase Prestalia from verified Canadian pharmacy.
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