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Ofev is a prescription medication used to treat idiopathic pulmonary fibrosis (IPF), a chronic and progressive lung disease that causes scarring and thickening of lung tissues. Ofev is known as a tyrosine kinase inhibitor. OFEV works by blocking the release of certain proteins that are responsible for the accumulation of scar tissue in the lungs, which is a common symptom associated with IPF.
Nintedanib can be used alone or in combination with other medications used for treatment of lung fibrosis such as mycophenolate. The effectiveness of nintedanib for treatment of fibrosis in other organs such as skin thickening is not established. It is also used to treat chronic fibrosing interstitial lung diseases (ILD) in which lung biopsy has shown marked interstitial fibrosis.
Uses and Dosage
Nintedanib comes in the form of an oral capsule and is taken twice daily. There are two available strengths: 150 mg capsules. Take Nintedanib exactly as prescribed and do not crush, chew, or break the capsules. The target dose is 150 mg twice daily, but depending on individual patient factors, such as adverse effects or laboratory abnormalities, a lower dose may be recommended by the healthcare provider.
Common Side Effects of Ofev (Nintedanib):
- Abdominal pain
- Decreased weight
- Liver enzyme elevation
- Skin ulcer
Serious Side Effects of Ofev (Nintedanib):
- Arterial thromboembolic events
- Bleeding events
- Decreased weight
- Myocardial infarction
Form and strength
Ofev (Nintedanib) is available in the following forms and strength:
- 100 mg
- 150 mg
- During treatment with Ofev, there have been reports of elevations in ALT (alanine transaminase), AST (aspartate transaminase), and bilirubin levels. Monitor these levels before and during treatment. Temporary reductions in dosage or even discontinuations may be necessary.
- Caution should be taken when treating patients at higher cardiovascular risk, including those with known coronary artery disease, and that treatment interruption should be considered in some cases.
- Take OFEV should stop smoking prior to treatment and avoid smoking during treatment. Patients should also inform their doctor of any other medications they are taking and any other medical conditions they may have.
- Women of childbearing potential who are prescribed Nintedanib should be counseled about the potential risk to the fetus and advised to avoid becoming pregnant.
- At the first signs of diarrhea, nausea or vomiting while taking OFEV, initiate symptomatic treatment with adequate hydration, antidiarrheal medicine such as loperamide or anti-emetics. If severe diarrhea, nausea, or vomiting persists despite treatment, discontinue OFEV.
- Nursing mothers should discontinue nursing or discontinue the use of Nintedanib. The decision to discontinue the drug or nursing should be made considering the importance of the drug to the mother. Discuss any concerns or questions about the use of Nintedanib with a healthcare provider.
Frequently Asked Questions (FAQ)
What is Ofev used for?
Ofev (nintedanib) is used to treat idiopathic pulmonary fibrosis (IPF).
How does Ofev work?
Ofev works by blocking several enzymes involved in the development of IPF, which helps to slow down the scarring of lung tissue.
How is Ofev taken?
Ofev is taken as capsules by mouth, usually twice a day with food.
How long does it take for Ofev to work?
It may take several weeks or months before the effects of Ofev are seen. It is important to continue taking Ofev as directed even if you do not feel an immediate improvement.
What should I do if I miss a dose of Ofev?
If you miss a dose of Ofev, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed dose.
It's important to purchase Ofev from verified Canadian pharmacy.