Metanx should be used under the supervision of a healthcare provider.
Before taking Metanx, tell your healthcare provider about your medical conditions, allergies, and all prescription medications, over-the-counter products, vitamins, and supplements you use.
Allergic Reactions
Do not take Metanx if you are allergic to L-methylfolate, pyridoxal 5′-phosphate, methylcobalamin, or any other ingredient in the product.
Allergic and skin reactions have been reported with some of the ingredients in Metanx.
Seek immediate medical attention if you develop difficulty breathing, swelling of the face, lips, tongue, or throat, or a severe skin reaction.
Vitamin B12 Deficiency
Folate can sometimes improve the blood-related signs of vitamin B12 deficiency without correcting the underlying neurological problems.
Although L-methylfolate may be less likely than ordinary folic acid to mask vitamin B12 deficiency, Metanx should not be used as a substitute for appropriate diagnosis and treatment of a true B12 deficiency.
Your healthcare provider may recommend blood tests if a vitamin B12 deficiency is suspected.
Avoid Excess Vitamin B6
Metanx already contains a substantial amount of vitamin B6 in the form of pyridoxal 5′-phosphate.
Do not add high-dose vitamin B6 or B-complex supplements unless your healthcare provider recommends them.
Excessive vitamin B6 intake over time can contribute to nerve-related symptoms such as numbness or tingling.
Other Vitamin Supplements
Tell your healthcare provider about all multivitamins and nutritional supplements you take.
Because Metanx already contains folate, vitamin B6, and vitamin B12, taking additional high-dose supplements may result in unnecessary or excessive intake.
Possible Digestive Side Effects
Some people may experience nausea, vomiting, abdominal discomfort, diarrhea, or loss of appetite while taking Metanx.
These effects are usually mild, but contact your healthcare provider if they become severe or persistent.
Skin and Sensitivity Reactions
Skin reactions, itching, rash, and increased sensitivity to sunlight have been reported with some of the ingredients in Metanx.
Contact your healthcare provider if you develop a new or persistent rash or other unusual skin symptoms.
Liver Function
Changes in liver function test results have been reported with pyridoxal 5′-phosphate.
Tell your healthcare provider if you have liver problems or a history of abnormal liver tests. Your provider may determine whether additional monitoring is appropriate.
Pregnancy and Breastfeeding
If you are pregnant, planning to become pregnant, or breastfeeding, talk to your healthcare provider before taking Metanx.
Although Metanx contains forms of essential B vitamins, the doses are higher than those typically found in standard multivitamins. Your healthcare provider can determine whether the product and dose are appropriate during pregnancy or breastfeeding.
Drug and Supplement Interactions
Tell your healthcare provider and pharmacist about all medications and supplements you use before starting Metanx.
Folate, vitamin B6, and vitamin B12 may interact with certain medications or affect how some treatments work.
Do not start additional vitamins or supplements without first checking with your healthcare provider.
Use Only as Directed
Do not take more Metanx than prescribed.
Taking additional capsules is unlikely to provide faster improvement and may increase your exposure to its active B vitamins.
Metanx is intended for use under medical supervision as part of the dietary management of peripheral neuropathy and related conditions.
REVIEWS