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Malarone is a fixed-dose combination medication that contains two active ingredients: atovaquone and proguanil hydrochloride. It is used for the prevention and treatment of malaria caused by mosquito bites in countries where malaria is common.

Malarone belongs to a class of drugs known as antimalarials. Malarone works by interfering with the growth and reproduction of the malaria parasites in the body, preventing and treating the infection.

Malaria parasites can enter the body through mosquito bites and cause serious illness or even death. Malarone is used to kill the malaria parasites living inside red blood cells and other tissues.

Uses and Dosage

Malarone is available as a tablet that should be taken by mouth with food or a milky drink (like whole milk or a milkshake) containing fat. If vomiting occurs within an hour of taking a dose, the dose should be repeated. Contact a doctor if vomiting persists after taking atovaquone/proguanil. Another medication to prevent vomiting or a different malaria medication may be needed.

The tablet should be taken whole and not chewed, as it has a bitter taste. If you have difficulty swallowing tablets, you may crush it and mix it with condensed milk, then take the mixture immediately.

Malarone (atovaquone / proguanil) comes in two strengths: an adult tablet containing 250 mg of atovaquone and 100 mg of proguanil, and a children's tablet containing 62.5 mg of atovaquone and 25 mg of proguanil. The typical dosing for Malarone depends on several factors, including the medical condition being treated or prevented, and the age and weight of the patient. Consult with your healthcare provider for specific dosing instructions.

Side effect

Common Side Effects of Malarone (Atovaquone/Proguanil):

  • Diarrhea
  • Dizziness
  • Headache
  • Low appetite
  • Nausea
  • Stomach pain
  • Vomiting
  • Weakness

Serious Side Effects of Malarone (Atovaquone/Proguanil):

  • Cough
  • Discouragement
  • Fear
  • Feeling sad or empty
  • Irritability
  • Lack of appetite
  • Loss of interest or pleasure
  • Mouth sores
  • Nervousness
  • Trouble concentrating
  • Vivid dreams

Form and Strength

Malarone (Atovaquone/Proguanil) is available in the following forms and strengths:

Malarone: Tablet

  • 62.5/25mg
  • 250/100mg

Atovaquone/Proguanil: Tablet

  • 250/100mg


  • Take Malarone exactly as prescribed by your healthcare provider. Do not skip doses or stop taking the medication without first consulting your healthcare provider.
  • Malarone can interact with other medications, including some antibiotics and anticonvulsants. Make sure to inform your healthcare provider of all medications you are currently taking before starting Malarone.
  • Malarone should be used with caution in patients with severe renal impairment or hepatic dysfunction, as it may cause increased drug concentrations in the body.
  • Malarone may cause certain side effects, such as headache, nausea, vomiting, abdominal pain, and diarrhea. If you experience any severe or persistent side effects, contact your healthcare provider immediately.
  • Malarone may not be suitable for pregnant or breastfeeding women, as its safety in these populations has not been established. Consult your healthcare provider before taking Malarone if you are pregnant or breastfeeding.
  • Malarone may cause allergic reactions in some people. If you experience symptoms such as rash, itching, swelling, dizziness or difficulty breathing, seek immediate medical attention.
  • Malarone may interact with some herbal or dietary supplements, including St. John's wort, which can decrease the effectiveness of the medication.
  • Malarone may increase the risk of sunburn or sun sensitivity in some individuals. Use sunscreen and wear protective clothing if you are exposed to direct sun while taking Malarone.
  • Malarone may lower the levels of folate in the body, which is important for fetal development. Women who are pregnant or planning to become pregnant may need to take additional folic acid supplements while taking Malarone.
  • Malarone may not be effective in all cases, and malaria prevention measures such as insecticide-treated bed nets and mosquito repellent should also be used to reduce the risk of infection.

Frequently Asked Questions (FAQ)

Can I drink alcohol while taking Malarone?

There is no known interaction between Malarone and alcohol. However, it is generally recommended to avoid excessive alcohol consumption while taking any medication.

Can I take Malarone if I am pregnant or breastfeeding?

Malarone may not be suitable for pregnant or breastfeeding women, as its safety in these populations has not been established. Consult your healthcare provider before taking Malarone if you are pregnant or breastfeeding.

What should I do if I forget to take a dose of Malarone?

If you miss a dose of Malarone, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule.

Is Malarone (atovaquone / proguanil) guaranteed to prevent malaria if I take it?

No, it is not guaranteed that taking Malarone (atovaquone / proguanil) (or any other preventative malaria medication) will completely prevent malaria. This is because there are several risk factors that affect your chances of getting infected.


Additional information

Generic name:





62.5/25mg, 250/100mg

Quantities Available:

12, 24


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Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Malarone (Atovaquone/Proguanil). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Malarone (Atovaquone/Proguanil).