Linzess (Linaclotide)

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Linzess Brand
Dosage Quantity & Price
Linaclotide (Generic alternate to Linzess) Generic

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Table of contents:

Linzess is a prescription medication used to treat chronic idiopathic constipation and irritable bowel syndrome with constipation (IBS-C). It works by increasing the natural secretion of fluid in the small intestine, which helps to soften stools and stimulate bowel movements.

Linzess is known for its efficacy, as clinical trials have shown it to be both safe and effective. It is an effective treatment for chronic constipation, allowing patients to experience relief from uncomfortable symptoms such as abdominal pain and bloating.

Linzess is an FDA-approved medication used to treat chronic constipation and irritable bowel syndrome with constipation (IBS-C). It is a once-daily capsule that helps reduce abdominal pain, bloating, and straining associated with these conditions.

The inactive ingredients of Linzess 72 mcg capsules include calcium chloride dihydrate, L-histidine, microcrystalline cellulose, polyvinyl alcohol, and talc, while the capsule shell is comprised of gelatin and titanium dioxide. The inactive ingredients of Linzess 145 mcg and 290 mcg capsules are calcium chloride dihydrate, hypromellose, L-leucine and microcrystalline cellulose, with the capsule shell being composed of gelatin and titanium dioxide.

Uses and Dosage

Adults should take Linzess on an empty stomach, at least 30 minutes before the first meal of the day. It is important to swallow Linzess whole without crushing or chewing it for maximum effectiveness. If a dose of Linzess is missed, it should be skipped, and the next dose should be taken at the regular time. Do not take two doses at the same time.

Alternatively, the contents of the capsule may be emptied into an ounce (30 milliliters) of water. The mixture should be swirled for 20 seconds and then consumed without chewing. An additional ounce (30 milliliters) of water should be added to the cup, swirled for 20 seconds, and then drunk immediately in order to receive the whole dose.

The water mixture can also be administered through a tube into the stomach (nasogastric or gastric tube). If you are administering this medication through a tube, be sure to consult your healthcare provider for detailed instructions on how to do so.

The recommended dosage of Linzess for Irritable Bowel Syndrome with Constipation (IBS-C) is 290 mcg orally once daily. For Chronic Idiopathic Constipation (CIC), the recommended dosage is 145 mcg orally once daily. Depending on an individual's presentation or tolerability, a dosage of 72 mcg once daily may be used.

Side effect

Linzess May Cause Serious Side Effects Including:

  • Black, bloody, or tarry stools
  • Confusion
  • Diarrhea with dizziness
  • Feeling unsteady
  • Fluttering in your chest
  • Increased thirst or urination
  • Irregular heartbeats
  • Leg cramps
  • Lightheadedness
  • Limp feeling
  • Mood changes
  • Muscle weakness
  • Severe or ongoing diarrhea
  • Severe stomach pain

 Serious Side Effects of Linzess Includes

  • Severe diarrhea
  • Severe abdominal pain
  • Persistent vomiting

Form and strength

Linzess is available in the following forms and strength:

Linzess Capsule

  • 72 mcg
  • 145 mcg
  • 290 mcg


  • It is not known if taking Lexapro during pregnancy or while breastfeeding will harm the unborn baby or the nursing infant. Women who are pregnant or plan to become pregnant should discuss the risks and benefits of taking Lexapro with their healthcare provider.
  • Women who are breastfeeding or plan to breastfeed should also discuss the risks and benefits of taking Lexapro with their healthcare provider. In general, Lexapro is not recommended to be taken while pregnant or breastfeeding.
  • Linzess should not be administered to children under the age of two, as it may cause harm. Severe diarrhea is a potential side effect of Linzess, which can lead to severe dehydration due to the loss of a large amount of body water and salt.
  • If a doctor has informed you that you have a bowel blockage (intestinal obstruction), it is advised that you do not take Linzess.
  • LINZESS may interact with certain antibiotics, antifungals, and other medications. Let your doctor know of any medications you may be taking to ensure there are no interactions.

Frequently Asked Questions (FAQ)

Here are some frequently asked questions and answers about Linzess:

What is Linzess used to treat?

Linzess is used to treat irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC) in adults.

What is the active ingredient in Linzess?

The active ingredient in Linzess is Linaclotide.

What is the dosage of Linzess?

The recommended dosage of Linzess is 145mcg taken orally once daily with a glass of water.

How often should I take Linzess?

Linzess should be taken once a day, with or without food.

Does Linzess have any special storage instructions?

Linzess should be stored at room temperature away from moisture and heat. Do not store Linzess in the refrigerator or bathroom.

What is the most important information I should know about Linzess?

Linzess should be used as prescribed by your doctor. Do not take more or less than the recommended dosage. Also, be aware of any potential interactions with other medications that you may be taking.


It's important to purchase Linzess from verified Canadian pharmacy.

Additional information

Generic name:





72mcg, 145mcg, 290mcg

Quantities Available:

28, 30, 60, 84, 90


Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Linzess (Linaclotide). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Linzess (Linaclotide).