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Janumet (Sitagliptin/Metformin) Shopper Approved

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Janumet

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Prescription Prescription Required FormationFormulation: Tablet

Sitagliptin/Metformin

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Janumet (active ingredients: sitagliptin and metformin) is a prescription medication used to help control blood sugar levels in adults with type 2 diabetes.

It is used along with a healthy diet and regular exercise when treatment with both sitagliptin and metformin is appropriate.

Type 2 Diabetes

Type 2 diabetes is a long-term condition in which the body does not produce enough insulin or cannot use insulin effectively. This causes blood sugar (glucose) levels to become too high.

If left untreated, high blood sugar can increase the risk of serious complications, including:

  • Heart disease.
  • Stroke.
  • Kidney disease.
  • Nerve damage.
  • Vision loss.

By improving blood sugar control, Janumet helps lower the risk of these diabetes-related complications.

How Does Janumet Work?

Janumet combines two diabetes medications that work together to lower blood sugar in different ways.

Sitagliptin

Sitagliptin belongs to a group of medications called dipeptidyl peptidase-4 (DPP-4) inhibitors.

It works by increasing the levels of natural hormones called incretins, which help regulate blood sugar after meals. These hormones:

  • Stimulate the pancreas to release more insulin when blood sugar is high.
  • Reduce the release of glucagon, a hormone that tells the liver to produce glucose.

Together, these effects help lower blood sugar levels, particularly after eating.

Metformin

Metformin belongs to a group of medications called biguanides.

It helps lower blood sugar by:

  • Reducing the amount of glucose produced by the liver.
  • Improving the body’s sensitivity to insulin.
  • Helping muscles use glucose more effectively.
  • Decreasing the absorption of glucose from the intestines.

Unlike some diabetes medications, metformin does not usually cause low blood sugar when used on its own.

Combined Benefits

By combining sitagliptin and metformin, Janumet helps:

  • Lower blood sugar levels.
  • Improve the body’s response to insulin.
  • Reduce glucose production by the liver.
  • Lower blood sugar after meals.
  • Support long-term blood sugar control when used with diet and exercise.

For the best results, take Janumet exactly as prescribed, even if you feel well. Continue following your recommended meal plan, exercise routine, and blood sugar monitoring schedule while taking this medication.

Janumet is available as an oral tablet that should be taken exactly as prescribed by your healthcare provider.

It is usually taken twice daily with meals. Taking Janumet with food helps reduce the risk of stomach upset caused by metformin.

Swallow the tablet whole with a glass of water. Do not crush, split, or chew the tablet unless your healthcare provider instructs you to do so. If you have difficulty swallowing the tablet, let your healthcare provider know.

Drink plenty of fluids while taking Janumet unless your healthcare provider advises you to limit your fluid intake.

Take your medication at the same times each day to help maintain a consistent level of medication in your body.

Recommended Dosages

The dose of Janumet is individualized based on your:

  • Current diabetes treatment.
  • Blood sugar levels.
  • Kidney function.
  • Response to therapy.

Your healthcare provider will determine the most appropriate dose for you.

The maximum recommended daily dose of Janumet is:

  • 100 mg of sitagliptin.
  • 2,000 mg of metformin hydrochloride (HCl).

For people who are already taking metformin 850 mg twice daily, the usual starting dose is:

  • Janumet 50 mg sitagliptin/1,000 mg metformin hydrochloride twice daily, taken with meals.

Your healthcare provider may adjust your dose based on your blood sugar control and how well you tolerate the medication.

Important Tips

  • Take Janumet twice daily with meals.
  • Swallow the tablets whole with water.
  • Do not crush, split, or chew the tablets.
  • Drink plenty of fluids unless your healthcare provider advises otherwise.
  • Take your medication at the same times each day.
  • Continue following your recommended diet, exercise program, and blood sugar monitoring schedule while taking Janumet.
  • Do not stop taking Janumet without consulting your healthcare provider, even if your blood sugar levels improve.

Common Side Effects of Janumet (Sitagliptin/Metformin):

  • Constipation
  • Diarrhea
  • Dizziness
  • Fatigue or weakness
  • Headache
  • Joint pain
  • Metallic taste in the mouth
  • Muscle pain
  • Nausea
  • Stomach upset
  • Vomiting

Serious Side Effects of Janumet (Sitagliptin/Metformin)

  • Change in urine output
  • Loss of appetite
  • Persistent vomiting
  • Severe stomach pain
  • Shortness of breath
  • Signs of hyperglycemia (thirst, confusion, increased urination, fruity breath odor)
  • Signs of hypoglycemia (sudden sweating, blurred vision, shaking, fast heartbeat, dizziness, tingling of the hands and feet)
  • Signs of lactic acidosis (stomach symptoms that return or occur after the first days of treatment)
  • Sudden weight gain
  • Unusual skin blisters

Janumet (Sitagliptin/Metformin) is available in the following forms and strengths:

Janumet: Tablet

  • 50/500 mg
  • 50/1000 mg

Sitagliptin/Metformin: Tablet

  • 50/500 mg
  • 50/850 mg
  • 50/1000 mg

Before taking Janumet, tell your healthcare provider about your complete medical history, including any allergies, medical conditions, and all medications you are taking. This helps ensure the medication is safe and appropriate for you.

Medical Procedures and Contrast Dye

Tell your healthcare provider or dentist that you are taking Janumet before:

  • Any surgery.
  • An X-ray or CT scan that uses iodinated contrast dye.

Your healthcare provider may recommend temporarily stopping Janumet before and after the procedure to reduce the risk of kidney problems and a rare but serious side effect called lactic acidosis. Follow your healthcare provider’s instructions carefully about when to stop and restart the medication.

Allergic Reactions

Do not take Janumet if you are allergic to sitagliptin, metformin, or any of the ingredients in the medication.

Some inactive ingredients may also cause allergic reactions in certain people. If you are unsure about the ingredients, ask your pharmacist for more information.

Seek emergency medical attention immediately if you develop signs of a serious allergic reaction, including:

  • Rash or hives.
  • Severe itching.
  • Swelling of the face, lips, tongue, or throat.
  • Difficulty breathing or swallowing.

Pregnancy

If you are pregnant, planning to become pregnant, or breastfeeding, tell your healthcare provider before taking Janumet.

Pregnancy can affect blood sugar levels and may require changes to your diabetes treatment plan. Your healthcare provider will determine the safest way to manage your blood sugar during pregnancy.

Kidney Problems

Janumet should not be used by people with severe kidney disease or diabetic ketoacidosis.

Your healthcare provider will perform blood tests before starting treatment and periodically during treatment to monitor your kidney function and determine whether Janumet remains safe for you.

Tell your healthcare provider if you notice symptoms that may suggest kidney problems, such as:

  • Swelling of the feet or ankles.
  • Changes in urination.
  • Unusual fatigue.
  • Shortness of breath.

Dizziness and Blurred Vision

Janumet may cause blurred vision, dizziness, or drowsiness, particularly if your blood sugar becomes too high or too low.

Until you know how Janumet affects you, do not drive, operate machinery, or perform activities that require alertness or clear vision.

Monitor your blood sugar regularly and follow your healthcare provider’s recommendations to help keep your blood sugar within your target range.

Regular Monitoring

While taking Janumet, your healthcare provider may regularly monitor your:

  • Blood sugar levels.
  • Kidney function.
  • Vitamin B12 levels (during long-term treatment).
  • Overall response to therapy.

Keeping your follow-up appointments and having regular blood tests can help ensure the medication remains safe and effective.

How long does Janumet take to work?

Janumet begins lowering blood sugar soon after you start taking it, and many people notice improvements within about 5 days of regular use. However, the full effect depends on factors such as your blood sugar levels, dose, diet, exercise habits, and overall health. Continue taking Janumet as prescribed and monitor your blood sugar regularly.

Who should not take Janumet?

Janumet should not be used by people with severe kidney disease, diabetic ketoacidosis (DKA), or a history of a serious allergic reaction to sitagliptin, metformin, or any of the ingredients in the medication. Your healthcare provider will determine whether Janumet is safe and appropriate for you based on your medical history and overall health.

How should I take Janumet?

Take Janumet exactly as prescribed by your healthcare provider. It is usually taken twice daily with meals to help reduce stomach upset. Your dose is based on your medical condition, kidney function, current diabetes treatment, and response to therapy.

Are there any drug interactions with Janumet?

Yes. Janumet may interact with certain medications, including diuretics (water pills), corticosteroids (steroids), and some heart or blood pressure medications. Before starting Janumet, tell your healthcare provider about all prescription medications, over-the-counter medicines, vitamins, and herbal supplements you are taking so they can check for potential drug interactions.

Is Janumet safe to use during pregnancy?

If you are pregnant, planning to become pregnant, or breastfeeding, talk to your healthcare provider before taking Janumet. Pregnancy can affect blood sugar control, and your healthcare provider will determine the safest treatment option for you. Do not start or stop Janumet during pregnancy without medical advice.

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Additional Information Book
Generic name:

Sitagliptin/Metformin

Formulation:

Tablet

Strength(s):

50/500mg, 50/850mg, 50/1000mg

Quantities Available:

56, 60, 90, 112, 168

Why customers love Online Pharmacies Canada

Our online Canadian Pharmacy is known for high standards of quality, safety, and efficiency when it comes to medications.

Our pharmacy offers lower prices on prescription drugs compared to traditional pharmacies.

How to Order

How much Janumet can I order at once from a Canadian pharmacy?

When ordering Janumet (sitagliptin/metformin) from a Canadian pharmacy, you can typically purchase up to a 90-day supply at one time. This is common for prescription medications to ensure adequate management of chronic conditions without frequent refills.

Here’s what you need to know:

Dosage and Quantity: Janumet is available in various dosage strengths, such as 50/500 mg, 50/1000 mg, and 50/850 mg. The quantity for a 90-day supply would depend on the specific dosage strength prescribed by your healthcare provider and how many tablets you are instructed to take each day.

For example, if prescribed Janumet 50/1000 mg to be taken twice daily, for a 90-day supply, you would order 180 tablets (90 days x 2 tablets per day).

Do you sell sitagliptin/metformin?

Yes, we sell sitagliptin/metformin! You can enjoy low prices on this medication by ordering from our website. To place an order, you will need a valid prescription from your healthcare provider, as we require this to dispense the medication safely and accurately. You can conveniently submit your prescription by mail, fax, or by uploading it through your online account during the ordering process.

Do you offer shipping of Janumet (sitagliptin/metformin) to the United States?

Yes, we ship Janumet (sitagliptin/metformin) to both the United States and Puerto Rico.

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Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Janumet (Sitagliptin/Metformin). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Janumet (Sitagliptin/Metformin).