Indications
Janumet (active ingredients: sitagliptin and metformin) is a prescription medication indicated for:
- Type 2 Diabetes Mellitus: Janumet is used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus when treatment with both sitagliptin and metformin is appropriate.
Janumet belongs to a class of drugs known as dipeptidyl peptidase-4 (DPP-4) inhibitors (sitagliptin) and biguanides (metformin). Sitagliptin works by increasing the levels of incretin hormones, which stimulate insulin release and decrease glucagon levels, thereby lowering blood sugar levels. Metformin works by decreasing glucose production in the liver, improving insulin sensitivity in muscle and adipose tissue, and reducing glucose absorption in the intestines, thereby lowering blood sugar levels.
Uses and Dosage
Janumet comes in the form of a tablet, and it should be taken orally as directed by a doctor. The usual dosage is twice a day with meals and need to drink plenty of fluids while taking it, unless otherwise directed by the doctor. The tablet should not be broken or cut before taking it. If you have difficulty swallowing the tablet whole, you should inform your doctor.
The recommended dosage of Janumet may vary depending on the individual patient's condition, and it should be individualized by a doctor based on the patient's current therapy. As per the manufacturer, the maximum recommended daily dose of Janumet is 100 mg of sitagliptin and 2000 mg of metformin hydrochloride (HCl). For patients taking metformin HCl 850 mg twice daily, the recommended starting dose of Janumet is 50 mg sitagliptin and 1000 mg metformin HCl twice daily.
Side Effects
Common Side Effects of Janumet (Sitagliptin/Metformin):
- Constipation
- Diarrhea
- Dizziness
- Fatigue or weakness
- Headache
- Joint pain
- Metallic taste in the mouth
- Muscle pain
- Nausea
- Stomach upset
- Vomiting
Serious Side Effects of Janumet (Sitagliptin/Metformin)
- Change in urine output
- Loss of appetite
- Persistent vomiting
- Severe stomach pain
- Shortness of breath
- Signs of hyperglycemia (thirst, confusion, increased urination, fruity breath odor)
- Signs of hypoglycemia (sudden sweating, blurred vision, shaking, fast heartbeat, dizziness, tingling of the hands and feet)
- Signs of lactic acidosis (stomach symptoms that return or occur after the first days of treatment)
- Sudden weight gain
- Unusual skin blisters
Form and Strength
Janumet (Sitagliptin/Metformin) is available in the following forms and strengths:
Janumet: Tablet
- 50/500mg
- 50/850mg
- 50/1000mg
Sitagliptin/Metformin: Tablet
- 50/500mg
Caution
- Before any surgical or X-ray procedure with iodinated contrast, inform your doctor or dentist of all products you use, including prescription and nonprescription drugs and herbal products. Follow your doctor's instructions or ask them about temporarily discontinuing Janumet prior to the procedure.
- Before you start taking Janumet, inform your healthcare provider or pharmacist about any known allergies you may have related to sitagliptin or metformin, or any other allergies you may have. Speak with your pharmacist for further information and advice pertaining to Janumet and its potential side effects or interactions.
- If you are pregnant or planning to become pregnant while taking Janumet, consult with your doctor as soon as possible, as this may warrant changes in your treatment plan. Pregnancy can affect blood sugar levels and may require adjustments to the dosage or type of medication used to manage diabetes.
- Janumet should not be taken by individuals with severe kidney problems or diabetic ketoacidosis. Before and during treatment, doctors will perform blood tests to monitor kidney function and ensure the medication is being properly metabolized.
- When taking Janumet, there is a risk of experiencing blurred vision, dizziness, or drowsiness due to excessively high or low blood sugar levels. Avoid driving, using machinery, or performing any activities that require clear vision or alertness until you are confident you can do so safely.
Frequently Asked Questions (FAQ)
How long does it take for Janumet to work?
This drug starts working within 5 days of regular use.
Who should not take Janumet?
Individuals with severe kidney problems, diabetic ketoacidosis, or a history of a serious allergic reaction to either metformin or sitagliptin should not take these medications.
How should Janumet be taken?
These medications should be taken with food to reduce the risk of side effects. Dosage will vary depending on the individual and should be determined by a healthcare provider.
Are there any potential drug interactions with Janumet?
Yes, certain medications can interact with these drugs, such as diuretics, steroids, and some heart and blood pressure medications. Consult with your healthcare provider before taking any new medications in combination with Janumet.
Is Janumet safe to use during pregnancy?
Janumet is not recommended for use during pregnancy, as it may increase the risk of birth defects.
REVIEWS