Hyalgan (Sodium Hyaluronate)

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Hyalgan Brand

We don't sell this brand-version medication.

Sodium Hyaluronate (Generic alternate to Hyalgan) Generic

We don't sell this generic-version medication.

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Table of contents:

Hyalgan is a synovial fluid replacement therapy used to treat knee pain caused by osteoarthritis. It is injected into the knee and contains sodium hyaluronate which acts as a lubricant and shock absorber in the joint. It works by acting as a lubricant and shock absorber in the knee joint, helping the joint to move more smoothly and reducing pain.

Sodium hyaluronate is a natural substance found in the body, and Hyalgan is made from a purified form of this substance. The treatment involves a series of injections directly into the knee joint, and the number of injections required can vary depending on the severity of the condition.

Hyalgan is typically used in patients who have not responded to conservative treatment options and have failed to find adequate pain relief. Hyalgan should only be used under medical supervision.

Uses and Dosage

Hyalgan is given by injection into the affected joint once a week. To prepare for the injection, avoid using skin disinfectants that contain ammonium salts like benzalkonium chloride. Your doctor may need to remove extra fluid from the joint before injecting the medicine.

Dosage is dependent on your medical condition and response to treatment. Avoid injecting hyaluronate into veins or arteries due to increased side effects. After receiving the injection, refrain from activities that put pressure on the knee for 48 hours. It is normal to experience increased pain and swelling in the knee after the injection, but if this persists, consult your doctor. Stay on schedule with injections, as it may take up to 3 injections before the full benefits of this medication occur.

Side effect

Common Side Effects of Hyalgan (Sodium Hyaluronate):

  • Back pain
  • Cold symptoms (stuffy nose, sneezing, sore throat)
  • Headache
  • Injection site reactions (pain, swelling, redness, warmth, bruising, stiffness, or puffiness)
  • Itching or skin irritation around the knee
  • Nausea
  • Numbness or tingly feeling
  • Stomach pain
  • Tired feeling

 Serious Side Effects of Hyalgan (Sodium Hyaluronate):

  • Fast or pounding heartbeat
  • Fever
  • Severe headache

Form and Strength

Hyalgan (Sodium Hyaluronate) is available in the following forms and strength:

Hyalgan: Injection

  • 20 mg/2ml


  • Hyalgan should not be used in patients who are allergic to hyaluronan products or who have infections in the knee joint.
  • Hyalgan is contraindicated in patients who are allergic to avian proteins (e.g., feathers, eggs).
  • Patients should inform their healthcare provider if they are pregnant or breastfeeding before using Hyalgan.
  • There is limited data on the safety of Hyalgan in patients with asthma, so caution should be taken when administering this medication to such patients.
  • Patients who experience an increase in pain or swelling after receiving Hyalgan injections should contact their healthcare provider.
  • Hyalgan may interact with other medications, so patients should inform their healthcare provider of any other medications they are taking before receiving Hyalgan treatment.

Frequently Asked Questions (FAQ)

How many injections of HYALGAN are necessary to see the full benefits of the medication?

It may take up to 3 injections before the full benefits of this medication occur.

What should I do if I experience increased pain and swelling in my knee after receiving the injection?

If the pain or swelling continues or worsens, talk to your doctor promptly.

What should I avoid doing after receiving an injection of HYALGAN?

Avoid any activities that put stress on your knee (such as jogging, tennis, heavy lifting, standing on your feet for more than an hour) for 48 hours.

Can skin disinfectants containing ammonium salts be used to prepare the injection site?

No, skin disinfectants that contain ammonium salts (such as benzalkonium chloride) should not be used to prepare the injection site.


It's important to purchase Hyalgan from verified Canadian pharmacy.

Additional information

Generic name:

Sodium Hyaluronate





Quantities Available:

1syr, 3syr


Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Hyalgan (Sodium Hyaluronate). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Hyalgan (Sodium Hyaluronate).