Glyxambi (Empagliflozin/Linagliptin)

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Glyxambi Brand
Dosage Quantity & Price
Empagliflozin/Linagliptin (Generic alternate to Glyxambi) Generic

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Table of contents:

Glyxambi is a prescription medication used to improve glycemic (blood sugar) control in adults with type 2 diabetes. It is a combination drug containing two medicines, empagliflozin and linagliptin.

Empagliflozin belongs to a class of drugs called sodium-glucose co-transporter-2 (SGLT2) inhibitors, which work by preventing the kidneys from reabsorbing glucose into the bloodstream, thus increasing the amount of glucose excreted in the urine.

Linagliptin belongs to the class of drugs called dipeptidyl peptidase-4 (DPP-4) inhibitors, which work by increasing the level of incretin hormones in the body, which in turn stimulate the pancreas to produce insulin in response to meals.

Glyxambi is taken orally and is usually used in conjunction with diet and exercise to manage type 2 diabetes. It can be used to reduce the risk of cardiovascular death and prevent complications such as blindness, nerve problems, kidney damage, loss of limbs, and sexual dysfunction.

Uses and Dosage

Glyxambi is usually prescribed as a once-daily tablet and should be taken orally, either with or without food, as directed by a healthcare provider. To take the medication, swallow the tablet whole and drink a glass of water. Do not split, chew, or crush the tablet.

The dosage of Glyxambi may vary depending on an individual's medical condition, and it is crucial to follow the specific instructions provided by a healthcare provider. Take Glyxambi regularly and on a set dosing schedule for the best results. Do not change your dose or stop using the medication abruptly without consulting with your healthcare provider.

The recommended dose of Glyxambi is usually 10 mg empagliflozin/5 mg linagliptin taken once daily, typically in the morning, with or without food. This dosage may be increased to 25 mg empagliflozin/5 mg linagliptin once daily depending on your response to the medication and your medical condition. However, the exact dosage may depend on individual factors, so consult with a doctor before taking any medication or changing your dosage.

Side effect

Common Side Effects of Glyxambi (Empagliflozin/Linagliptin):

  • Dizziness
  • Frequent urination
  • Lightheadedness
  • Nausea
  • Stomach upset

Serious Side Effects of Glyxambi (Empagliflozin/Linagliptin):

  • Change in urinary output
  • Dehydration
  • High blood sugar
  • Joint pain
  • Low blood sugar
  • Signs of a yeast infection (unusual discharge and itching of vagina or penis)
  • Signs of heart failure (shortness of breath, swelling of the extremities, sudden weight gain)
  • Signs of pancreatic disease (persistent vomiting, severe abdominal pain which radiates to the back)
  • Signs of urinary tract infection (painful/difficult urination, bloody urine, fever)
  • Trouble breathing
  • Unusual skin blisters
  • Unusual tiredness

Form and strength

Glyxambi (Empagliflozin/Linagliptin) is available in the following forms and strength:

Glyxambi: Tablet

  • 10/5 mg
  • 25/5 mg


  • Glyxambi should not be taken if you are on dialysis.
  • Do not take Glyxambi if you are on dialysis, have severe kidney problems, or are allergic to linagliptin, empagliflozin, or any of the ingredients in Glyxambi.
  • The limited available data with Glyxambi, linagliptin, or empagliflozin suggests caution in patients predisposed to ketoacidosis and those with a history of pancreatitis.
  • Glyxambi should be used with caution in patients with a history of urinary tract infections or genital mycotic infections.
  • Use caution when using Glyxambi with medications that can increase the risk of dehydration, such as diuretics.
  • Glyxambi may cause hypoglycemia (low blood sugar), especially when used in conjunction with insulin or other drugs that lower blood sugar levels. Symptoms of hypoglycemia include shakiness, dizziness, sweating, confusion, and headache.
  • Glyxambi can increase the risk of urinary tract infections, yeast infections, and dehydration in some people.
  • People taking Glyxambi should be aware of the signs of ketoacidosis, a serious condition that can develop in people with diabetes. Symptoms of ketoacidosis include fruity-smelling breath, nausea, vomiting, abdominal pain, and difficulty breathing.

Frequently Asked Questions (FAQ)

How is Glyxambi taken?

Glyxambi is usually taken once daily, with or without food as directed by a healthcare provider. It should be swallowed whole with a glass of water and not chewed, split, or crushed.

Can Glyxambi be used to treat type 1 diabetes?

No, Glyxambi is only approved for the treatment of type 2 diabetes.

Can Glyxambi cause weight loss?

Some people may experience weight loss while taking Glyxambi due to the medication's ability to increase urination, which can lead to fluid loss. However, weight loss is not a guaranteed effect of the medication and may not be significant.

Can Glyxambi be taken with other diabetes medications?

It depends on the specific medications being taken. Glyxambi can be used in combination with some other diabetes drugs but check with a healthcare provider to ensure that any potential drug interactions are avoided.


It's important to purchase Glyxambi from verified Canadian pharmacy.

Additional information

Generic name:





10/5mg, 25/5mg

Quantities Available:



Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Glyxambi (Empagliflozin/Linagliptin). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Glyxambi (Empagliflozin/Linagliptin).