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Amaryl generically known as Glimepiride is a medication used to control blood sugar levels in people with type 2 diabetes. Glimepiride belongs to a drug class known as sulfonylureas. Sulfonylureas work by stimulating the pancreas to release insulin to lower your blood sugar levels.

Amaryl works by increasing the body’s sensitivity to insulin and stimulating the pancreas to produce more insulin. It may also help slow down the rate at which glucose is absorbed from food and reduce cravings for sweets.

Glimepiride should not be used for the treatment of type 1 diabetes mellitus or diabetic ketoacidosis, as it will not be effective in these cases. It is only indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Uses and Dosage

Amaryl (glimepiride) comes in the form of tablets used to lower blood sugar levels in people with type 2 diabetes. It is taken orally, with breakfast or the first main meal of the day. Take Amaryl regularly to get the most benefit from it. To help you remember, take it at the same time each day. If you miss a dose, take it as soon as you remember. If it is close to the time for the next dose, just take the next dose at the regular time. Do not double up on doses.

  • The recommended starting dose of Amaryl for patients at increased risk for hypoglycemia is 1 mg once daily. After reaching a daily dose of 2 mg, further dose increases can be made in increments of 1 mg or 2 mg based on the patient's glycemic response and should not occur more frequently than every 1 to 2 weeks.
  • Patients being transferred from longer half-life sulfonylureas may have overlapping drug effect for 1 to 2 weeks and should be monitored for hypoglycemia. The maximum recommended dose is 8 mg once daily.

Side Effects

Common Side Effects of Amaryl (Glimepiride):

  • Dizziness
  • Fast heart rate or palpitations
  • Headache
  • Irritability
  • Lightheadedness
  • Nausea
  • Nervousness or anxiety
  • Sweating
  • Trembling or shaking
  • Unexplained weight gain
  • Weakness

Form and Strength

Amaryl and its generic alternative of Glimepiride are available in the following forms and strengths:

Amaryl: Tablet

  • 1 mg
  • 2 mg
  • 3 mg
  • 4 mg

Glimepiride: Tablet

  • 1 mg
  • 2 mg
  • 3 mg
  • 4 mg


  • While taking glimepiride, it is important to avoid drinking alcohol as it can lower your blood sugar and interfere with your diabetes treatment. Additionally, it is important to avoid exposure to sunlight or tanning beds, as glimepiride can make you sunburn more easily.
  • Taking Amaryl (glimepiride) can increase your risk of death from heart problems when compared to other methods of controlling blood sugar, such as diet alone or diet and insulin. Talk to your provider about the risks and benefits of taking Amaryl (glimepiride) to make sure it is the right medication for you.
  • Amaryl (glimepiride) may interact with certain medications or supplements. Let your doctor and pharmacist know about any other medications or supplements (prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are taking.
  • Note that patients who have previously had an allergic reaction to a sulfonamide derivative may be at risk of having an allergic reaction to Amaryl. Therefore, it is recommended that those with a history of an allergic reaction to sulfonamide derivatives should not use Amaryl. Reported hypersensitivity reactions include cutaneous rashes, fever, and hemolytic anemia.

Frequently Asked Questions (FAQ)

What is the best time to take Amaryl?

You'll usually take glimepiride once a day. Take this medicine with food. Most people take it in the morning with their breakfast. If you do not eat breakfast, make sure you take it with your first meal of the day.

How long does it take for Amaryl to start working?

How long does it take to work? Amaryl should lower your blood sugar within 2 to 3 hours after you take your dose. Its effects can last up to 24 hours. It may take 2 weeks of treatment with Amaryl for you and your doctor to determine if your dosage is working well.

Will I need to take this drug long term?

Amaryl is typically used as a long-term treatment. If you and your doctor determine that Amaryl is safe and effective for you, you will likely take it long term.


Additional information

Generic name:





1mg, 2mg, 3mg, 4mg

Quantities Available:

30, 90, 100, 180


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Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Amaryl (Glimepiride). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Amaryl (Glimepiride).