Indications
Enablex generically known as Darifenacin is a muscarinic antagonist indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and frequency.
Enablex belongs to the class of drugs known as antispasmodics. It works by blocking the action of a chemical called acetylcholine, which is involved in the contraction of the muscles in the bladder. By blocking this action, Darifenacin can help reduce the symptoms of an overactive bladder.
Uses and Dosage
Enablex (darifenacin) comes in the form of Extended-Release Tablet to take by mouth with or without food as directed by your doctor. Swallow the extended-release tablets whole, without crushing or chewing them, with a full glass of water (8 ounces/240 milliliters). It is usually taken once a day or as directed by your healthcare provider.
To ensure maximum efficacy, use Enablex regularly and try to take it at the same time each day. Swallowing the tablets whole is important, as crushing or chewing them can release all the drug at once, increasing the risk of side effects.
The recommended starting dose of Enablex is 7.5 mg orally once daily. Based upon individual response, the dose may be increased to 15 mg once daily, as early as two weeks after starting therapy.
Side Effect
Common Side Effects of Enablex (Darifenacin):
- Blurred vision
- Body aches
- Constipation
- Diarrhea
- Dizziness
- Drowsiness
- Dry eyes
- Dry mouth
- Fever
- Headache
- Indigestion
- Nausea
- Other flu symptoms
- Sore throat
- Stomach pain or upset
- Weakness
Serious Side Effects of Enablex (Darifenacin):
- Bloody urine
- Burning while urinating
- Confusion
- Dehydration
- Hallucinations
- Inability to urinate
- Severe constipation
- Severe stomach pain
Form and Strength
Enablex (Darifenacin) is available in the following forms and strength:
Enablex: Extended-Release Tablet
- 7.5 mg
- 15 mg
Darifenacin: Extended-Release Tablet
- 7.5 mg
- 15 mg
Caution
- Enablex can cause adverse reactions including dry mouth, constipation, blurred vision, dizziness, and urinary retention.
- Darifenacin may interact with other medications, such as ketoconazole, ritonavir, and other medications that also affect the urinary tract or the central nervous system. Inform your doctor of all medications you are taking before starting treatment with darifenacin.
- Darifenacin should not be taken by individuals with certain medical conditions, including gastric retention, uncontrolled narrow-angle glaucoma, and urinary retention related to bladder outlet obstruction. It should be used with caution in those with hepatic and renal impairment.
- Do not use darifenacin during pregnancy or while breastfeeding.
- Enablex may cause serious side effects such as angioedema and anaphylaxis.
- Enablex should be administered with caution to patients with clinically significant bladder outflow obstruction, decreased gastrointestinal motility, controlled narrow-angle glaucoma, or urinary retention.
- Individuals taking darifenacin should have regular blood tests to monitor their liver and kidney function, especially if they have pre-existing liver or kidney disease.
- Taking more than the recommended dose of darifenacin may cause symptoms such as dry mouth, flushing, blurred vision, and confusion. In severe cases, an overdose can cause agitation, tachycardia, and hallucinations.
- Enablex should be administered with caution to patients with clinically significant bladder outflow obstruction, decreased gastrointestinal motility, controlled narrow-angle glaucoma, or urinary retention.
- Patients with renal or hepatic impairment should use Enablex with caution and may require dosage adjustments.
- Patients taking Enablex should avoid alcohol and other central nervous system depressants as they can worsen side effects.
Frequently Asked Questions (FAQ)
How should I take Enablex?
Enablex should be taken exactly as prescribed by your healthcare provider. Typically, it is taken once per day, with or without food. Do not crush, chew, or break the tablet. Swallow the tablet whole with a full glass of water.
Can I drink alcohol while taking Enablex?
You should avoid drinking alcohol while taking Enablex, as it can worsen side effects such as dizziness and drowsiness.
Can I take Enablex with other medications?
Enablex may interact with other medications, so you should inform your healthcare provider of all medications you are taking, including over-the-counter medications, vitamins, and herbal supplements.
How long does it take for Enablex to start working?
The effects of Enablex may take several weeks to become noticeable. Continue taking the medication as prescribed by your healthcare provider.
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