Depakote (Divalproex)

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Depakote Brand
Dosage Quantity & Price
Divalproex (Generic alternate to Depakote) Generic
Dosage Quantity & Price
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Table of contents:

Depakote, generically known as Divalproex sodium, is a medication commonly prescribed to treat various conditions including seizures, migraines, and bipolar disorder. It is a member of the class of medications known as anticonvulsants or anti-epileptics, which work by affecting the chemicals in the brain that are involved in causing seizures and pain.

Divalproex sodium, a coordination compound of sodium valproate and valproic acid, is a widely used medication for the treatment of manic episodes associated with bipolar disorder, epilepsy, and migraine headaches. Its therapeutic effects are thought to be related to increased brain concentrations of gamma-aminobutyric acid (GABA) and restoring the balance of certain neurotransmitters in the brain.

Depakote (divalproex) is an anti-seizure medication used to treat certain types of seizure disorders and manic episodes associated with bipolar disorder. It is also used to prevent migraine headaches. Depakote can be an effective treatment for both severe and mild symptoms of these conditions. Depakote has been available for many decades and has proven to be an effective treatment for a variety of conditions.

Uses and Dosage

Depakote should be taken orally, ideally with a meal to minimize potential stomach discomfort and upset. The entire tablet should be swallowed with a glass of water. Splitting or chewing the tablet should be avoided, as it could potentially cause irritation to the mouth and throat.

A dosing schedule should be established to ensure that doses are not missed. The dosage of Depakote should not be adjusted, as it has been determined based on age, weight, medical condition, response to treatment, and any other medications being taken.

Depakote tablets are to be taken orally, with the recommended initial dose being 750 mg per day, split into multiple doses. The dosage should be increased as quickly as possible to reach the lowest therapeutic dose, producing the desired clinical effect or the desired range of plasma concentrations.

Depakote is indicated for the prevention of migraine headaches in adults. It should be taken orally, with the recommended initial dose being 250 mg twice daily. The dose should be adjusted as necessary to achieve the desired clinical effect or the desired range of plasma concentrations.

Side effects

Some Common Side Effects of Divalproex:

  • Blurred vision
  • Constipation
  • Diarrhea
  • Dizziness
  • Drowsiness
  • Hair loss
  • Nausea
  • Ringing in the ears
  • Stomach upset
  • Tremors
  • Weight changes

Serious Side Effect of Divalproex

  • Chest pain
  • Easy bruising and bleeding
  • Irregular heartbeat
  • Loss of consciousness
  • Mental or mood problems
  • Rapid breathing
  • Severe vomiting
  • Shivering
  • Swelling of extremities
  • Uncontrolled eye movement or nystagmus
  • Unexplained weakness

Form and strength

Depakote and its Generic Alternatives Divalproex are available in the following forms and strengths:

Depakote Delayed Release Tablet

  • 125 mg
  • 250 mg
  • 500 mg

Divalproex Delayed Release Tablet

  • 125 mg
  • 250 mg
  • 500 mg


  • Prior to administering divalproex, you should provide your physician or pharmacist with your medical history, particularly if you have a history of liver disease, pancreatitis, metabolic disorders (e.g., urea cycle disorders, Alpers - Huttenlocher syndrome), alcohol abuse, bleeding issues, brain degeneration (e.g., dementia), kidney disease, dehydration, or malnutrition.
  • Abruptly discontinuing this medication should be avoided, as it may lead to withdrawal symptoms such as anxiety, irritability, dizziness, tremors, and a return of manic and depressive episodes.
  • Patients taking divalproex may experience feelings of dizziness, somnolence, or blurred vision. The concomitant use of alcohol or marijuana (cannabis) may further enhance these effects. Hence, it is recommended to avoid activities that necessitate alertness or clear vision until the effects of divalproex have dissipated.
  • If you are currently pregnant or plan to become pregnant in the future, it is important to inform your doctor. It is advised to avoid taking divalproex sodium while pregnant, as it may have adverse effects on the unborn child.
  • To lower the chance of getting cut, bruised, or injured, use caution with sharp objects like razors and nail cutters, and avoid activities such as contact sports.
  • Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Frequently Asked Questions (FAQ)

Is Depakote high risk?

Taking Depakote has been linked to some serious and even deadly side effects. Liver damage is one of the side effects that may be fatal. This is especially true in children under 2. This risk is highest in the first months of taking the medication.

What to avoid when taking Depakote?

You need to avoid alcohol while taking either of these drugs. This is because drowsiness or dizziness are side effects of Depakote, Depakote ER, and alcohol.

Who cannot take Depakote?

Due to an increased risk for liver problems, people with certain inherited metabolic disorders (such as Alpers-Huttenlocher syndrome) should not use this medication. Children younger than 2 years who might have these disorders should not use this medication.

Can you stop Depakote suddenly?

Depakote tapering a gradual, carefully managed reduction is the safest way to stop taking this mood stabilizer, classed as an antiepileptic medication. Abruptly stopping Depakote is NOT recommended as it can result in seizures that do not stop and other serious withdrawal symptoms.


It's important to purchase Depakote from verified Canadian pharmacy.

Additional information

Generic name:



Delayed Release Tablet, Delayed Release Tablet (Enteric Coated)


125mg, 250mg, 500mg

Quantities Available:

90, 100