Akynzeo (Netupitant/Palonosetron)

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Akynzeo Brand
Dosage Quantity & Price
Netupitant/Palonosetron (Generic alternate to Akynzeo) Generic

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Table of contents:

Akynzeo is a prescription medicine used in combination with dexamethasone to help prevent nausea and vomiting caused by chemotherapy in adults with cancer. It is a combination of two medications: netupitant and palonosetron. Netupitant works by blocking the action of substance P, which is involved in nausea and vomiting. Palonosetron blocks the action of serotonin, which is another source of nausea and vomiting.

Akynzeo is a fixed-dose combination of two drugs: netupitant, a neurokinin 1 receptor antagonist, and palonosetron, a 5-HT3 receptor antagonist. The combination of these two drugs helps to prevent nausea and vomiting both in the acute phase, which occurs within the first 24 hours after chemotherapy, and in the delayed phase, which occurs over the next few days after chemotherapy.

Uses and Dosage

Akynzeo (Netupitant/Palonosetron) Capsules should be taken as directed by your healthcare provider. Always follow the specific instructions given by your healthcare provider regarding Akynzeo and consult them if you have any concerns or questions about how to use it. The Capsules may be taken with or without food, but the capsule should be swallowed whole and not crushed or chewed.

The usual recommended dose is one capsule (300 mg netupitant/0.5 mg palonosetron) taken orally 1 hour before chemotherapy treatment. Do not exceed the recommended dose of Akynzeo, as it may cause side effects. Additionally, inform your doctor or pharmacist about any other medications or supplements you are taking, as they may interact with Akynzeo and affect its effectiveness.

Side effect

Common Side Effects of Akynzeo (Netupitant/Palonosetron):

Signs of an Allergic Reaction to Akynzeo:

  • Hives
  • Chest pain
  • Difficult breathing
  • Swelling of your face, lips, tongue, or throat

Serious Side Effects of Akynzeo (Netupitant/Palonosetron):

  • Agitation
  • Chest pain
  • Diarrhea
  • Difficulty breathing
  • Fast heart rate
  • Fever
  • Hallucinations,
  • Hives
  • Loss of coordination
  • Muscle stiffness
  • Nausea
  • Shivering
  • Sweating
  • Swelling of your face, lips, tongue, or throat
  • Twitching
  • Vomiting

Form and strength

Akynzeo (Netupitant/Palonosetron) is available in the following forms and strength:

Akynzeo: Capsules

  • 300mg/0.5mg


  • If you are considering taking Akynzeo, inform your doctor if you are pregnant or planning to become pregnant as the medication's components, netupitant and palonosetron, may have harmful effects on an unborn baby.
  • Akynzeo can cause drowsiness and dizziness, avoid driving or operating heavy machinery until you know how the medication affects you.
  • Akynzeo should not be taken by anyone who is allergic to netupitant or palonosetron. Discuss any other medical conditions or medications you may be taking with your healthcare provider to determine if Akynzeo is appropriate for you.
  • Akynzeo may prolong the QT interval, which can lead to a serious heart rhythm problem called Torsades de Pointes. Therefore, caution is required when using Akynzeo in patients with a history or risk factors for QT interval prolongation.
  • Caution is recommended in patients with severe hepatic impairment. Limited data is available on the use of Akynzeo in these patients.
  • Akynzeo may interact with other medications, including those that also prolong the QT interval. Caution is recommended when using Akynzeo with other medications that can cause QT interval prolongation or Torsades de Pointes.

Frequently Asked Questions (FAQ)

Can I take Akynzeo with other medications?

Discuss all medications you are taking with your healthcare provider, including prescription drugs, over-the-counter medications, and herbal supplements, to avoid potential drug interactions.

How often should I take Akynzeo?

Your healthcare provider will provide specific instructions for when and how often to take Akynzeo, as this can depend on individual factors such as the type of chemotherapy you are receiving.

How quickly does Akynzeo work?

Akynzeo can start working within a few hours of taking it and can continue to provide relief for up to five days after the last dose is taken.

Is Akynzeo addictive?

No, Akynzeo is not addictive.


It's important to purchase Akynzeo from verified Canadian pharmacy.

Additional information

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Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Akynzeo (Netupitant/Palonosetron). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Akynzeo (Netupitant/Palonosetron).