Lokelma (Sodium Zirconium Cyclosilicate) Shopper Approved

Prescription Prescription Required FormationFormulation: Powder for Oral Suspension


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Prescription Prescription Required FormationFormulation: Powder for Oral Suspension

Sodium Zirconium Cyclosilicate

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Lokelma is a medication used for the treatment of hyperkalemia, which is characterized by elevated levels of potassium in the blood. It is an insoluble, non-absorbed sodium zirconium silicate formulated as a powder for oral suspension that works as a highly selective potassium binder.

Lokelma acts directly in the intestines and is not absorbed into the bloodstream. Lokelma is indicated for the treatment of hyperkalemia in adults and should not be used as an emergency treatment for life-threatening hyperkalemia.

Uses and Dosage

Lokelma comes as a powder for oral suspension to be taken by mouth as directed by a doctor. Patients taking Lokelma should take other medications at least 2 hours before or 2 hours after taking Lokelma. The initial dose may be taken 3 times a day for the first 48 hours and then decreased to once daily or once every other day.

For patients undergoing dialysis, the medication should only be taken on non-dialysis days. To prevent any potential interactions, other medications should be taken at least 2 hours before or after taking Lokelma. Follow your doctor's instructions carefully, and your dosage will be determined based on your medical condition and response to treatment, with blood tests ordered to monitor your progress.

Side Effects

Allergic Reactions of Lokelma:

  • Skin rash
  • Itching or hives
  • Swelling of the face, lips, or tongue

Serious Side Effects of Sodium Zirconium Cyclosilicate:

Form and Strength

Lokelma (Sodium Zirconium Cyclosilicate)) is available in the following forms and strengths:

 Lokelma: Powder for Oral Suspension

  • No dose


  • Alcohol can increase the risk of side effects of Lokelma, such as dizziness or headaches. It is best to avoid alcohol while taking Lokelma.
  • Lokelma can cause allergic reactions such as swelling of the face, lips, or throat, difficulty breathing or swallowing, and hives. If you experience any of these symptoms, seek medical attention immediately.
  • People with severe kidney problems should not take Lokelma. If you have kidney problems, talk to your doctor before taking Lokelma.
  • If you are allergic to sodium zirconium cyclosilicate, or if you have any other allergies, you should inform your healthcare provider before taking this medication. The product may contain inactive ingredients that may cause allergic reactions or other issues. Speak to your pharmacist for further information.
  • If you are taking sodium zirconium cyclosilicate and are scheduled to have an X-ray of your stomach or abdomen, inform the X-ray personnel beforehand. It can affect the results of some tests such as abdominal or stomach X-rays.
  • If you have stomach problems, like bowel obstruction (blockage in your gut) or severe constipation, speak to your provider before taking Lokelma. It is not known if Lokelma is safe or works well in people with these conditions.

Frequently Asked Questions (FAQ)

How do I take Lokelma?

Lokelma is taken orally as a powder that is mixed with water. The dosage and timing of Lokelma will be determined by your healthcare provider based on your individual needs.

How long does it take for Lokelma to work?

Lokelma can start working about an hour after it is taken and continues to work for up to 24 hours.

Can I take Lokelma with food?

Lokelma can be taken with or without food. However, it should not be taken with other medication. Your doctor will tell you how to take Lokelma.

How does Lokelma work?

Lokelma works by binding to potassium in the body, which helps remove excess potassium from the blood.


Additional information

Generic name:

Sodium Zirconium Cyclosilicate


Powder for Oral Suspension



Quantities Available:

3 sachets, 30 sachets


Additional Information Book

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Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Lokelma (Sodium Zirconium Cyclosilicate). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Lokelma (Sodium Zirconium Cyclosilicate).