Actoplus Met (Pioglitazone/Metformin)

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Actoplus Met Brand
Dosage Quantity & Price
Pioglitazone/Metformin (Generic alternate to Actoplus Met) Generic
Dosage Quantity & Price
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Table of contents:

Actoplus Met is a prescription medication used to help control blood sugar levels in people with type 2 diabetes. It contains a combination of two drugs: pioglitazone and metformin. Pioglitazone is a thiazolidinedione drug that helps reduce insulin resistance in the body, while metformin is a biguanide drug that helps decrease glucose production in the liver and improve insulin sensitivity.

Actoplus Met can be used together with diet and exercise for people who do not use daily insulin injections to control high blood sugar. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke.

Use and Dosage

Actoplus Met is typically taken orally, usually once or twice a day, and is intended to be used in combination with a healthy diet and exercise plan to help manage diabetes. Take the tablet with meals once or twice daily to reduce stomach upset, and drink plenty of fluids unless directed otherwise by your doctor.

The recommended dosages of Actoplus Met depend on several factors and can vary from patient to patient. The maximum recommended daily dose of Actoplus Met is 15mg/850mg when used in combination with certain medications, and doses above 2000mg/day may be better tolerated if split into three or more doses. Additionally, Actoplus Met should be taken regularly at the same time(s) each day to get the most benefit from it, and it may take up to 2 to 3 months before the full benefit of the drug takes effect.

Check your blood sugar regularly as directed and share the results with your doctor. Notify your doctor if your blood sugar is too high or too low, as your dosage/treatment may need to be adjusted. It may take up to 2 to 3 months before the drug takes full effect.

Side Effects

Common Side Effects of Actoplus Met (Pioglitazone/Metformin):

  • Cold-like symptoms
  • Diarrhea
  • Headache
  • Swelling
  • Weight gain

Serious Side Effects of Actoplus Met (Pioglitazone/Metformin):

  • Back pain
  • Chest pain
  • Muscle pain
  • Sinus infection
  • Sore throat

Forms and Strength

Actoplus Met (Pioglitazone/Metformin) is available in the following forms and strength:

Actoplus Met: Tablet

  • 15/850 mg

Pioglitazone/Metformin: Tablet

  • 15/500 mg
  • 15/850 mg


  • Congestive Heart Failure: Actoplus Met can cause or worsen congestive heart failure, particularly in patients who already have heart problems. This caution is also highlighted in the boxed warning on the drug's label.
  • Lactic Acidosis: Actoplus Met can cause a rare but serious condition called lactic acidosis, which is a buildup of lactic acid in the body. This condition can be life-threatening and requires immediate medical attention.
  • Liver Problems: Actoplus Met can cause liver problems, and patients with liver disease or abnormal liver function should use this medication with caution.
  • Bladder Cancer: Studies have shown that Actoplus Met may increase the risk of bladder cancer. Patients should report any symptoms of bladder cancer, such as blood in the urine, to their healthcare provider.
  • Hypoglycemia: Actoplus Met can cause low blood sugar, particularly when used in combination with other diabetes medications. Patients should monitor their blood sugar regularly and report any symptoms of hypoglycemia, such as sweating, shaking, or confusion, to their healthcare provider.
  • Pregnancy and Breastfeeding: Actoplus Met is not recommended for use during pregnancy or breastfeeding. Women who are pregnant or considering becoming pregnant should discuss the risks and benefits of this medication with their healthcare provider.
  • Edema: Actoplus Met can cause or worsen edema (fluid retention), particularly in patients who already have edema or heart failure.
  • Bone Fractures: Studies have shown that Actoplus Met may increase the risk of bone fractures, particularly in women.
  • Interactions with Other Medications: Actoplus Met can interact with other medications, including medications that lower blood sugar and medications that affect liver function. Patients should check with their healthcare provider before taking any other medications while using Actoplus Met.

Frequently Asked Questions (FAQ)

How should I take Actoplus Met?

Actoplus Met is usually taken twice a day with meals. It should be taken exactly as prescribed by your doctor.

What should I do if I miss a dose of Actoplus Met?

If you miss a dose of Actoplus Met, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule.

Will Actoplus Met cure my diabetes?

No, Actoplus Met will not cure your diabetes. It is used to help control blood sugar levels, but it does not cure the underlying condition.

Can Actoplus Met cause low blood sugar levels?

Yes, Actoplus Met can cause low blood sugar levels, especially if it is taken in combination with other diabetes medications or if meals are skipped.


It's important to purchase Actoplus Met from verified Canadian pharmacy.

Additional information

Generic name:





15/500mg, 15/850mg

Quantities Available:

56, 90, 100, 112, 180