Wellbutrin (Bupropion)

Indications

Wellbutrin (Bupropion) is a medication that is often prescribed to treat depression and other mental health conditions. It belongs to a class of medications known as antidepressants/ aminoketones. These antidepressants work by changing the levels of certain chemicals in the brain that are responsible for mood.

Wellbutrin can be used alone or in combination with other medications. It works on the brain’s neurotransmitters to regulate mood and behavior. Knowing how Wellbutrin works can be helpful for patients who are considering taking the drug.

Wellbutrin has a unique mechanism of action compared to other antidepressants and is considered both effective and safe for long-term use. Wellbutrin is also sometimes prescribed off label for conditions such as chronic pain, seasonal affective disorder, and smoking cessation.

Uses and Dosage

Bupropion comes in the form of a tablet and should be taken by mouth with or without food as directed by your doctor, usually three times daily. If you experience stomach upset, it is recommended to take this drug with food. It is advised to take your doses at least 6 hours apart, or as directed by your doctor, to reduce the risk of having a seizure.

The tablet should not be crushed, cut, or chewed before taking it. Taking the medication as prescribed by your doctor is important to ensure that the medication is effective and safe. Additionally, talk to your doctor if you have any questions or concerns about the dosage that has been prescribed.

The recommended oral dosage of Bupropion tablet for treating depression in adults is 100 mg two times per day, with the dose not exceeding 150 mg three times per day, taken at least 6 hours apart. For children, the use and dose must be determined by a doctor.

Side Effects

Common Side Effects of Bupropion

• Anxiety
• Dry mouth
• Hyperventilation
• Irregular heartbeats
• Irritability
• Restlessness
• Shaking
• Trouble sleeping

Serious Side Effects of Bupropion

• Confusion
• Fainting
• False beliefs that cannot be changed by facts
• Having extreme distrust of people
• Seeing, hearing, or feeling things that are not there
• Seizures
• Trouble concentrating

Form and Strength

Bupropion, the generic alternative Wellbutrin is available in the following forms and strengths:

Bupropion: Tablet

• 75 mg
• 100 mg

Caution

• The use of alcohol or other medicines that affect the CNS with bupropion may increase the risk of experiencing side effects such as dizziness, poor concentration, drowsiness, unusual dreams, and difficulty sleeping. Certain medications may interact with bupropion, so it is important to discuss any other medications you are taking with your doctor before starting bupropion.
• Bupropion is an antidepressant medication that may cause some people to experience agitation, irritability, or other abnormal behaviors. It can lead to suicidal thoughts and tendencies or make an existing depression worse. If you experience any of these symptoms, talk to your doctor as soon as possible.
• Avoid taking bupropion with a monoamine oxidase (MAO) inhibitor such as isocarboxazid (Marplan), linezolid (Zyvox), phenelzine (Nardil), selegiline (Eldepryl), or tranylcypromine (Parnate). Furthermore, it is advised not to start taking bupropion during the two weeks following the discontinuation of an MAO inhibitor.
• Bupropion may cause an increase in blood pressure, which can lead to headaches, dizziness, or blurred vision. It is generally recommended to measure your blood pressure at home regularly while taking bupropion, as this will help your doctor monitor any changes and make the necessary adjustments to your treatment.

Frequently Asked Questions (FAQ)

How should I take Wellbutrin?

Take Wellbutrin exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. Too much of this medicine can increase your risk of a seizure. Do not crush, chew, or break an extended-release tablet. Swallow it whole.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up for the missed dose.

How does Wellbutrin work?

Wellbutrin works by increasing the levels of certain brain chemicals. It is thought to work by blocking the reuptake of dopamine and norepinephrine in the brain, which increases the amount of these neurotransmitters that are available to the neurons in the brain.

Should I talk to my doctor before taking Wellbutrin?

Yes, it is important to talk to your doctor before taking Wellbutrin. Your doctor will be able to assess your medical history and any other medications you are taking to determine if Wellbutrin is the right choice for you.

Resources

• https://www.webmd.com/drugs/2/drug-13509/wellbutrin-oral/details
• https://www.nami.org/About-Mental-Illness/Treatments/Mental-Health-Medications/Types-of-Medication/Bupropion-(Wellbutrin)
• https://www.mayoclinic.org/drugs-supplements/bupropion-oral-route/proper-use/drg-20062478
• https://www.drugs.com/wellbutrin.html