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Duavee contains conjugated estrogens and bazedoxifene. It is a prescription medication used in postmenopausal women who still have a uterus. It has two main approved uses: treating moderate to severe hot flashes caused by menopause and helping prevent osteoporosis after menopause.
During menopause, the ovaries gradually make less estrogen. This hormonal change can cause symptoms such as hot flashes, flushing, sweating, and night sweats.
Hot flashes can happen suddenly and may last for several minutes. When they occur at night, they can interrupt sleep and affect daily comfort.
Duavee provides estrogen to help replace some of the hormone the body is no longer producing. This can help make hot flashes less frequent and less severe.
Duavee is also approved to help prevent postmenopausal osteoporosis.
Estrogen plays an important role in maintaining bone strength. After menopause, lower estrogen levels can cause bone to break down faster than the body can replace it. Over time, bones may become thinner and weaker, increasing the risk of osteoporosis and fractures.
The estrogen component of Duavee helps slow this bone loss and supports the maintenance of bone density.
When Duavee is being considered only for osteoporosis prevention, it is generally intended for postmenopausal women who are at a significant risk of osteoporosis.
Your healthcare provider may also consider non-estrogen osteoporosis treatments before deciding whether Duavee is the best option.
Duavee combines two medicines that act differently in the body.
Conjugated estrogens replace some of the estrogen that decreases after menopause. This helps relieve hot flashes and also helps reduce bone loss.
Bazedoxifene is an estrogen agonist/antagonist, also commonly described as a selective estrogen receptor modulator (SERM). It can act like estrogen in some tissues while blocking estrogen’s effects in others.
Estrogen can stimulate the lining of the uterus, known as the endometrium. When estrogen is used alone in someone who still has a uterus, prolonged stimulation can increase the risk of endometrial overgrowth and cancer.
Bazedoxifene helps block estrogen’s effects on the uterine lining. This is why Duavee combines estrogen with bazedoxifene rather than using estrogen alone.
Duavee is specifically approved for postmenopausal women with a uterus. The bazedoxifene component provides protection against excessive estrogen stimulation of the uterine lining.
This combination is different from estrogen-only therapy and from traditional estrogen-plus-progestin hormone therapy.
No. Duavee does not stop or reverse menopause.
Instead, it helps manage certain effects of lower estrogen levels, particularly moderate to severe hot flashes, and may help protect against bone loss while the medication is being used.
Menopause can cause vaginal dryness, burning, or discomfort, but these symptoms are not listed as a specific approved indication for Duavee. Its current U.S. indications are moderate to severe vasomotor symptoms and prevention of postmenopausal osteoporosis in women with a uterus.
If vaginal symptoms are the main concern, a healthcare provider may recommend a treatment specifically intended for those symptoms.
The length of treatment depends on your symptoms, osteoporosis risk, medical history, and response to the medication.
Duavee should be used for the shortest duration that meets your treatment goals while considering your individual risks. Your healthcare provider should periodically reassess whether you still need treatment.
Duavee combines conjugated estrogens with bazedoxifene to treat moderate to severe menopausal hot flashes and help prevent osteoporosis in postmenopausal women who have a uterus.
The estrogen helps relieve menopause symptoms and reduce bone loss, while bazedoxifene helps limit estrogen stimulation of the uterine lining. Use Duavee exactly as prescribed and have your need for continued treatment reviewed regularly by your healthcare provider.
Duavee contains conjugated estrogens 0.45 mg and bazedoxifene 20 mg in each tablet. It is prescribed for certain postmenopausal women who still have a uterus. Its two approved uses are treating moderate to severe hot flashes caused by menopause and helping prevent osteoporosis after menopause.
Duavee is used to treat moderate to severe vasomotor symptoms of menopause, which commonly include hot flashes and night sweats.
During menopause, estrogen levels decrease. This change can affect the body’s temperature regulation and cause sudden episodes of warmth, flushing, sweating, and nighttime symptoms.
The conjugated estrogens in Duavee help replace some of the estrogen that decreases after menopause. This can reduce how often hot flashes occur and how severe they feel.
Duavee is also approved to help prevent postmenopausal osteoporosis.
Estrogen helps maintain bone strength. After menopause, declining estrogen levels can cause bone to break down more quickly, gradually reducing bone density and increasing the risk of osteoporosis.
Duavee helps slow this bone loss. However, when the medication is being considered only for osteoporosis prevention, it should generally be reserved for women at significant risk of osteoporosis. A healthcare provider should also consider whether a non-estrogen treatment would be more appropriate.
Duavee combines two medications that have different effects on estrogen receptors.
Conjugated estrogens replace some of the estrogen lost after menopause. This helps relieve hot flashes and supports bone health.
Bazedoxifene is an estrogen agonist/antagonist, often described as a selective estrogen receptor modulator or SERM. In the uterus, it helps reduce the stimulating effect of estrogen on the uterine lining.
This combination allows Duavee to provide estrogen therapy while helping protect the endometrium in women who still have a uterus.
The recommended dose for both approved uses is:
One Duavee tablet by mouth once daily.
Each tablet provides 0.45 mg conjugated estrogens and 20 mg bazedoxifene. There is no separate higher or lower standard dose for hot flashes versus osteoporosis prevention.
Take one tablet once every day, preferably at about the same time to make it easier to remember.
Duavee may be taken with or without food. Swallow the tablet whole. Do not crush, chew, or split it.
Do not take additional estrogen-containing medicines while using Duavee unless specifically instructed by your healthcare provider.
Duavee already contains estrogen, and adding another estrogen product may increase estrogen exposure and the risk of side effects.
If you are taking Duavee to help prevent osteoporosis, your healthcare provider may recommend calcium and vitamin D supplements if you are not getting enough from your diet.
Adequate calcium and vitamin D are important for maintaining healthy bones after menopause.
If you miss a dose of Duavee, take it as soon as you remember.
However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular schedule.
Do not take two tablets at the same time to make up for a missed dose.
There is no single treatment length that is right for everyone.
Duavee should be used for the shortest duration that meets your treatment goals while considering your individual risks. Your healthcare provider should periodically review your symptoms, bone health, and medical history to decide whether treatment should continue.
Duavee is not recommended in women with kidney impairment because its effects and drug levels have not been adequately studied in this population.
Duavee has not been adequately studied in women older than 75 years, so its use in this age group is not recommended in the current prescribing information.
Duavee is taken as one tablet once daily for either moderate to severe menopausal hot flashes or prevention of postmenopausal osteoporosis. The dose should not be increased on your own if symptoms continue.
Your healthcare provider should regularly reassess whether you still need treatment and whether Duavee remains appropriate for your health needs.
Duavee (Conjugated Estrogens/Bazedoxifene) is available in the following forms and strengths:
Duavee contains conjugated estrogens and bazedoxifene, so it has important precautions related to blood clots, certain cancers, liver and gallbladder problems, and other estrogen-related effects. It should be used only as prescribed and for the shortest duration that meets your treatment goals.
Duavee may increase the risk of deep vein thrombosis, pulmonary embolism, and stroke. It should not be used if you currently have, or have previously had, certain blood clots, a stroke, or a heart attack.
Seek immediate medical attention if you develop sudden chest pain, shortness of breath, coughing up blood, pain or swelling in one leg, sudden weakness or numbness, difficulty speaking, or sudden vision changes.
Tell your healthcare provider if you experience unexpected or unexplained vaginal bleeding, especially after menopause.
Although bazedoxifene helps reduce estrogen’s effects on the uterine lining, unusual bleeding still needs to be evaluated because it may be a sign of a problem involving the uterus.
Duavee should not be used if you have known, suspected, or a past history of breast cancer or another estrogen-dependent cancer.
Tell your healthcare provider about any history of hormone-sensitive cancers before starting treatment.
While taking Duavee, do not take additional estrogen, progestins, or other estrogen agonist/antagonist medicines unless specifically directed by your healthcare provider.
Duavee already contains both estrogen and bazedoxifene, so adding similar medicines may increase the risk of side effects.
Duavee should not be used in women with known liver disease or liver impairment.
Contact your healthcare provider if you develop yellowing of the skin or eyes, dark urine, severe abdominal discomfort, or other possible signs of liver problems.
Estrogen therapy can increase the risk of gallbladder disease.
Tell your healthcare provider if you develop persistent or severe pain in the upper abdomen, especially if it occurs with nausea, vomiting, or fever.
Rarely, estrogen therapy may be associated with blood clots affecting the blood vessels of the eye.
Stop taking Duavee and seek prompt medical attention if you develop sudden partial or complete vision loss, double vision, or other sudden major changes in eyesight.
Estrogen can sometimes cause a significant rise in triglyceride levels, particularly in people who already have high triglycerides.
Tell your healthcare provider if you have a history of high triglycerides. Severe increases can contribute to inflammation of the pancreas.
If you take thyroid replacement medicine, estrogen may change the amount of thyroid hormone your body needs.
Your healthcare provider may monitor your thyroid levels and adjust your thyroid medication if necessary.
Duavee should not be used if you have certain inherited conditions that make your blood more likely to clot, including protein C deficiency, protein S deficiency, antithrombin deficiency, or other known thrombophilic disorders.
Duavee is intended for postmenopausal women and should not be used during pregnancy. The prescribing information lists pregnancy as a contraindication because the medication may harm an unborn baby.
Duavee is not recommended in women with kidney impairment because it has not been adequately studied in this group. It is also not recommended for women older than 75 years because there is not enough safety and effectiveness information for this age group.
Do not take Duavee if you have had a serious allergic reaction to conjugated estrogens, bazedoxifene, or any ingredient in the tablets.
Seek emergency medical care if you develop swelling of the face, lips, tongue, or throat, difficulty breathing, or another severe allergic reaction.
Before starting Duavee, tell your healthcare provider about all medical conditions and medications you take, especially a history of blood clots, stroke, heart attack, cancer, liver disease, gallbladder problems, high triglycerides, or thyroid disease.
Your healthcare provider should periodically review whether Duavee is still needed and whether its benefits continue to outweigh its risks.
The recommended dose is one tablet once daily. Each tablet contains conjugated estrogens 0.45 mg and bazedoxifene 20 mg.
Yes. Duavee can be taken with or without food. Try to take it at about the same time each day and swallow the tablet whole. Do not crush, chew, or split it.
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your normal schedule. Do not take two doses at the same time unless your healthcare provider tells you to.
There is no single treatment length that is right for everyone. Duavee should be used for the shortest amount of time that meets your treatment goals, while considering your individual risks. Your healthcare provider should periodically review whether you still need treatment.
Do not use additional estrogen, progestin, or other medicines that act on estrogen receptors with Duavee unless your healthcare provider specifically recommends it. Tell your healthcare provider about all prescription medicines, over-the-counter products, vitamins, and supplements you take because some medicines may interact with Duavee.
If you are using Duavee to help prevent osteoporosis and you do not get enough calcium or vitamin D from your diet, your healthcare provider may recommend supplements. Calcium and vitamin D supplements may be taken at the same time as Duavee.
Duavee can increase the risk of blood clots and stroke. It should not be used if you have an active or previous history of certain blood clots, stroke, heart attack, or certain blood-clotting disorders. Seek immediate medical attention if you develop sudden chest pain, shortness of breath, swelling or pain in one leg, sudden weakness or numbness, or difficulty speaking.
Duavee should not be used in women with liver disease or liver impairment. Tell your healthcare provider about any current or previous liver problems before starting treatment.
Duavee is not recommended for women with kidney impairment because it has not been adequately studied in this group.
Keep Duavee in its original blister packaging until you are ready to take a tablet. After opening the foil pouch containing the blister package, record the opening date and do not use the tablets if the pouch has been open for more than 60 days.
No. Duavee is a prescription medication. A healthcare provider will need to determine whether it is appropriate for your menopausal symptoms or osteoporosis prevention based on your medical history and individual risks.
| Generic name: | Conjugated Estrogens/Bazedoxifene |
|---|---|
| Formulation: | Tablet |
| Strength(s): | 0.45/20mg |
| Quantities Available: | 30 |
Our online Canadian Pharmacy is known for high standards of quality, safety, and efficiency when it comes to medications.
Our pharmacy offers lower prices on prescription drugs compared to traditional pharmacies.
When ordering Duavee (conjugated estrogens/bazedoxifene) from a Canadian pharmacy, you can typically purchase up to a 90-day supply at one time, which is common for prescription medications to ensure adequate management of chronic conditions without frequent refills.
Here’s what you need to know:
Dosage and Quantity: Duavee is prescribed as one tablet daily. Each tablet contains 0.45 mg of conjugated estrogens and 20 mg of bazedoxifene. For a 90-day supply, this means you would order 90 tablets (90 days x 1 tablet per day).
Our website doesn’t sell conjugated estrogens/bazedoxifene, but you can still enjoy low prices on Duavee, which contains conjugated estrogens/bazedoxifene as an active ingredient. You will need a valid prescription from your healthcare provider. We require this to dispense the medication. You can mail, fax, or upload your prescription through your online account.
Yes, we ship Duavee (conjugated estrogens/bazedoxifene) to both the United States and Puerto Rico.
Watch how Online Pharmacies Canada is helping customers save money on their medications.
Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Duavee (Conjugated Estrogens/Bazedoxifene). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Duavee (Conjugated Estrogens/Bazedoxifene).
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