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Arthrotec is a prescription medication that contains two active ingredients: diclofenac and misoprostol. It is used to relieve arthritis symptoms in people who also need protection from stomach ulcers caused by nonsteroidal anti-inflammatory drugs (NSAIDs).
Arthrotec is commonly prescribed for adults with rheumatoid arthritis or osteoarthritis who have a higher risk of developing stomach or intestinal ulcers. It helps reduce joint pain and inflammation while also helping protect the digestive tract from some of the harmful effects of diclofenac.
Rheumatoid arthritis is a long-term inflammatory condition that affects the joints. It occurs when the immune system mistakenly attacks the tissues surrounding the joints.
This condition may cause joint pain, swelling, warmth, stiffness, and reduced movement. The symptoms often affect both sides of the body and may be worse in the morning or after long periods of rest.
Arthrotec helps reduce the pain, swelling, and stiffness associated with rheumatoid arthritis. By controlling inflammation, the medication may make it easier to move the affected joints and perform daily activities.
However, Arthrotec does not cure rheumatoid arthritis. It also does not directly treat the immune system problem that causes the condition.
Osteoarthritis is a common form of arthritis that develops when the cartilage protecting the ends of the bones gradually wears down. It often affects weight-bearing joints, such as the knees, hips, and spine, but it may also affect the hands.
People with osteoarthritis may experience pain, stiffness, tenderness, swelling, and reduced flexibility. The pain may become worse during movement or after physical activity.
Arthrotec helps relieve osteoarthritis symptoms by reducing pain and inflammation in the affected joints. This may improve comfort, mobility, and the ability to complete everyday activities.
The medication helps manage symptoms, but it does not rebuild damaged cartilage or reverse existing joint damage.
NSAIDs such as diclofenac are effective for arthritis pain and inflammation. However, they can reduce the natural substances that help protect the lining of the stomach and intestines.
As a result, NSAID use may lead to stomach irritation, ulcers, bleeding, or other digestive problems. The risk may be higher in older adults, people who take NSAIDs for a long time, and people with a previous history of stomach ulcers or gastrointestinal bleeding.
The misoprostol in Arthrotec helps reduce the risk of developing gastric and duodenal ulcers while taking diclofenac. It provides additional protection for the stomach and intestinal lining, although it does not completely remove the risk of ulcers or bleeding.
Arthrotec combines diclofenac and misoprostol because each ingredient has a different role.
Diclofenac
Diclofenac belongs to a group of medicines called nonsteroidal anti-inflammatory drugs. It works by blocking cyclooxygenase enzymes, also known as COX enzymes.
These enzymes help the body produce prostaglandins. Some prostaglandins contribute to pain, swelling, inflammation, and fever.
By reducing the production of these prostaglandins, diclofenac helps decrease joint pain, swelling, tenderness, and stiffness. This can make movement more comfortable for people with arthritis.
However, prostaglandins also help maintain the protective lining of the stomach and intestines. When diclofenac lowers these protective prostaglandins, the digestive tract may become more vulnerable to irritation and ulcers.
Misoprostol
Misoprostol is a synthetic form of prostaglandin E1. It helps replace some of the protective prostaglandins that are reduced by diclofenac.
Misoprostol helps protect the digestive tract by lowering stomach acid production. It also increases the production of mucus and bicarbonate, which form a protective barrier over the stomach lining.
This protection helps reduce the likelihood of ulcers developing during NSAID treatment.
Combined Effect
The two ingredients in Arthrotec work together to provide arthritis symptom relief and stomach protection.
Diclofenac reduces pain and inflammation, while misoprostol helps protect the stomach and intestinal lining from NSAID-related damage. This combination may be useful for people who need ongoing arthritis treatment but have an increased risk of developing digestive ulcers.
Arthrotec helps control arthritis symptoms and lowers the risk of certain NSAID-related ulcers. However, it does not cure arthritis or completely prevent serious stomach and intestinal complications.
Take Arthrotec exactly as prescribed by your healthcare provider. The appropriate dose depends on the condition being treated, your response to the medication, your risk of stomach ulcers, and how well you tolerate treatment.
Swallow each tablet whole with water. Do not crush, chew, split, or dissolve the tablet because this can damage its delayed-release coating and may release the medication too quickly.
Take Arthrotec with food to help reduce stomach discomfort and diarrhea. Taking the medication at the same times each day can help you maintain a consistent dosing schedule and avoid missed doses.
Use the lowest effective dose for the shortest amount of time needed to control your symptoms. Do not increase the dose, take it more frequently, or continue treatment longer than prescribed. Do not stop taking Arthrotec or change your treatment schedule without speaking with your healthcare provider.
Arthrotec is available in two strengths:
For osteoarthritis, the recommended dosage that provides the greatest protection for the stomach lining is one Arthrotec 50 tablet taken three times daily.
People who cannot tolerate this schedule may be prescribed one Arthrotec 75 tablet twice daily or one Arthrotec 50 tablet twice daily. However, taking the medication twice daily may provide less protection against stomach and intestinal ulcers than taking Arthrotec 50 three times daily.
The total diclofenac dose should generally not exceed 150 mg per day when Arthrotec is used for osteoarthritis.
For rheumatoid arthritis, the recommended dosage that provides the greatest protection for the stomach lining is one Arthrotec 50 tablet taken three or four times daily.
People who cannot tolerate this schedule may be prescribed one Arthrotec 50 tablet twice daily or one Arthrotec 75 tablet twice daily. Lower-frequency dosing may be easier to tolerate, but it may provide less protection against ulcers.
The total diclofenac dose should generally not exceed 200 mg per day when Arthrotec is used for rheumatoid arthritis.
Misoprostol commonly causes diarrhea, stomach pain, or cramping, especially when treatment begins. A healthcare provider may adjust the dosing frequency if these effects become difficult to tolerate.
The total daily dose of misoprostol should not exceed 800 mcg, and no more than 200 mcg should be taken at one time. Your healthcare provider may prescribe diclofenac and misoprostol as separate medications if the fixed doses in Arthrotec do not meet your individual treatment needs.
If you miss a dose, take it when you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose.
Arthrotec (Diclofenac/Misoprostal) is available in the following forms and strength:
Do not take Arthrotec during pregnancy. Misoprostol can cause uterine contractions, miscarriage, premature birth, uterine rupture, or birth defects. Diclofenac may also harm the developing baby, especially later in pregnancy.
People who can become pregnant should use effective birth control during treatment. Before starting Arthrotec, a healthcare provider may require a negative pregnancy test. Contact your healthcare provider immediately if you become pregnant or think you may be pregnant while taking this medication.
Tell your healthcare provider if you are breastfeeding or plan to breastfeed. Diclofenac and substances produced from misoprostol may pass into breast milk. Your healthcare provider will consider the benefits of breastfeeding, your need for treatment, and the possible risks to the nursing baby before recommending Arthrotec.
The safety and effectiveness of Arthrotec have not been established in children. For this reason, it is generally prescribed only to adults unless a qualified healthcare provider determines otherwise.
Arthrotec may cause dizziness, drowsiness, blurred vision, or tiredness in some people. These effects may reduce your ability to react quickly or concentrate.
Do not drive, operate machinery, or perform potentially dangerous activities until you know how the medication affects you. Alcohol may make dizziness or drowsiness worse and can also increase the risk of stomach bleeding.
Arthrotec contains misoprostol to help protect the digestive tract, but serious stomach or intestinal complications can still occur. These may include inflammation, ulcers, bleeding, or a hole in the stomach or intestine.
These problems can develop at any time and may occur without warning symptoms. The risk is greater in older adults and in people who:
Tell your healthcare provider about any history of ulcers, gastrointestinal bleeding, inflammatory bowel disease, or other digestive conditions before starting treatment.
Seek immediate medical attention if you develop black or bloody stools, vomit that contains blood or looks like coffee grounds, severe stomach pain, fainting, or unusual weakness.
Diclofenac and other NSAIDs may increase the risk of a heart attack, stroke, blood clot, or other serious cardiovascular problem. These events can occur without warning and may be fatal. The risk may increase with higher doses, longer treatment, or an existing history of heart or blood vessel disease.
Tell your healthcare provider if you have heart disease, high blood pressure, high cholesterol, diabetes, circulation problems, or a history of heart attack or stroke. Arthrotec should not be used around the time of coronary artery bypass graft surgery.
Seek emergency care if you develop chest pain, shortness of breath, weakness on one side of the body, or difficulty speaking.
Arthrotec may cause new or worsening high blood pressure. It may also cause the body to retain fluid, leading to swelling or worsening heart failure.
Your healthcare provider may check your blood pressure before and during treatment. Report swelling in your feet, ankles, legs, or hands, rapid weight gain, or difficulty breathing.
Diclofenac can reduce blood flow to the kidneys and may cause new or worsening kidney problems. The risk is higher in older adults and in people who have kidney disease, heart failure, liver disease, dehydration, or low blood volume.
Some blood pressure medicines and water pills can further increase this risk. Your healthcare provider may order blood tests to monitor your kidney function during treatment.
Contact your healthcare provider if you notice reduced urination, swelling, unexplained weight gain, unusual tiredness, or shortness of breath.
Arthrotec may cause abnormal liver test results or, rarely, serious liver injury. Tell your healthcare provider if you have liver disease or regularly consume alcohol.
Your healthcare provider may monitor your liver function, especially during long-term treatment. Stop taking the medication and seek medical advice promptly if you develop yellowing of the skin or eyes, dark urine, persistent nausea, unusual tiredness, loss of appetite, itching, or pain in the upper-right abdomen.
Diclofenac can affect blood clotting and may increase the risk of bleeding. It may also contribute to anemia, particularly when long-term gastrointestinal blood loss occurs.
Tell your healthcare provider if you have a bleeding disorder, anemia, or take medication that affects blood clotting. Blood tests may be needed during long-term treatment.
Report unusual bruising, prolonged bleeding, pale skin, shortness of breath, weakness, or unexplained tiredness.
Do not take Arthrotec if you have had an allergic reaction to diclofenac, misoprostol, aspirin, or another NSAID. People who have experienced asthma attacks, hives, or other allergic reactions after taking aspirin or an NSAID may have a serious reaction to Arthrotec.
Seek emergency care if you develop swelling of the face, lips, tongue, or throat; difficulty breathing; wheezing; hives; or a severe rash.
NSAIDs can rarely cause serious or life-threatening skin reactions. These may occur without warning, including during the first weeks of treatment.
Stop taking Arthrotec and seek medical attention immediately if you develop a spreading rash, blisters, peeling skin, fever, facial swelling, or sores in your mouth or around your eyes.
Arthrotec may interact with several prescription and non-prescription medications. Some combinations may increase the risk of bleeding, ulcers, kidney damage, or other serious complications.
Important interactions may include:
Corticosteroids and some antidepressants may further increase the risk of gastrointestinal bleeding. Blood pressure medicines and diuretics may become less effective or increase the risk of kidney problems when combined with Arthrotec.
Tell your healthcare provider about every prescription medication, over-the-counter product, vitamin, and supplement you use. Do not take aspirin, ibuprofen, naproxen, or another pain reliever with Arthrotec unless your healthcare provider approves the combination.
Arthrotec may begin relieving pain and inflammation within a few hours after a dose. However, it may take several days or weeks of regular use to experience its full benefit.
Yes. Take Arthrotec with food to help reduce stomach discomfort and diarrhea. Swallow the tablet whole with water, and do not crush, chew, or split it.
Take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose.
Store Arthrotec at room temperature in a dry place, away from heat and moisture. Keep the tablets in their original container and out of the reach of children and pets. Do not store Arthrotec in a bathroom or other damp area.
People with a history of stomach ulcers or gastrointestinal bleeding may have a higher risk of serious digestive complications while taking Arthrotec. Although Arthrotec contains misoprostol to help protect the stomach lining, it does not completely prevent ulcers or bleeding. A healthcare provider should carefully review the risks and monitor the patient during treatment.
| Generic name: | Diclofenac/Misoprostal |
|---|---|
| Formulation: | Tablet |
| Strength(s): | 50mg/200mcg, 75mg/200mcg |
| Quantities Available: | 120, 180, 240 |
Our online Canadian Pharmacy is known for high standards of quality, safety, and efficiency when it comes to medications.
Our pharmacy offers lower prices on prescription drugs compared to traditional pharmacies.
When ordering Arthrotec (diclofenac/misoprostol) from a Canadian pharmacy, you can typically purchase up to a 90-day supply at one time, which is standard for prescription medications to ensure effective management of chronic conditions without frequent refills.
Here’s what you need to know:
Dosage and Quantity: Arthrotec is available in different strengths, such as 50mg/200mcg and 75mg/200mcg. The dosage depends on the severity of your condition and your doctor’s prescription.
For example, if you are prescribed Arthrotec 50mg/200mcg and instructed to take one tablet twice daily, you would order 180 tablets for a 90-day supply (90 days x 2 tablets per day).
No, we do not sell diclofenac/misoprostol directly on our website. However, you can still enjoy low prices on Arthrotec, which contains diclofenac/misoprostol as an active ingredient. To purchase Arthrotec from us, you will need a valid prescription from your healthcare provider. We require this to ensure safe and legal dispensing of the medication. You can submit your prescription by mailing it to us, faxing it, or uploading it through your online account.
Yes, we ship Arthrotec (diclofenac/misoprostol) to both the United States and Puerto Rico.
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Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Arthrotec (Diclofenac/Misoprostal). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Arthrotec (Diclofenac/Misoprostal).
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