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Adcirca (active ingredient: tadalafil) is a prescription medication used to treat pulmonary arterial hypertension, also known as PAH.

PAH is a serious condition in which the arteries that carry blood from the heart to the lungs become narrowed, stiff, or damaged. This makes it harder for blood to move through the lungs and causes pressure to build inside the pulmonary arteries.

As the pressure increases, the right side of the heart must work harder to pump blood. Over time, this extra strain may weaken the heart and cause symptoms to become worse.

Pulmonary Arterial Hypertension

Pulmonary arterial hypertension is different from ordinary high blood pressure. It specifically affects the blood vessels in the lungs.

The condition may develop on its own or may be associated with other health problems, such as connective tissue disease, congenital heart disease, liver disease, or certain infections and medications.

Common symptoms may include:

  • Shortness of breath, especially during activity
  • Tiredness or weakness
  • Dizziness or fainting
  • Chest pressure or discomfort
  • A fast or pounding heartbeat
  • Swelling in the legs, ankles, or abdomen
  • Reduced ability to exercise
  • Bluish lips or skin in severe cases

Symptoms may be mild at first and become more noticeable as the condition progresses.

Mechanism of Action

Adcirca belongs to a class of medications called phosphodiesterase type 5 inhibitors, also known as PDE5 inhibitors.

The body produces a chemical called cyclic guanosine monophosphate, or cGMP, which helps blood vessels relax. An enzyme called PDE5 breaks down this chemical.

Adcirca blocks PDE5, allowing cGMP to remain active for longer. This helps relax and widen the blood vessels in the lungs.

As a result:

  • Blood flows more easily through the lungs
  • Pressure in the pulmonary arteries may decrease
  • The heart pumps against less resistance
  • Physical activity may become easier

Improvements in Exercise Capacity

Adcirca is used to improve exercise capacity in people with PAH. Exercise capacity refers to how much physical activity a person can perform before symptoms such as shortness of breath or tiredness become limiting.

Treatment may help some people:

  • Walk farther
  • Complete daily activities more comfortably
  • Experience less shortness of breath during activity
  • Maintain greater independence
  • Improve overall physical endurance

The response to treatment varies. Adcirca may improve symptoms, but it may not completely remove them.

Effects on the Heart

The right side of the heart pumps blood into the lungs. When pressure in the lung arteries is high, the heart must work much harder.

By relaxing the pulmonary blood vessels, Adcirca reduces some of the resistance against which the heart must pump. This may help reduce strain on the right side of the heart.

However, Adcirca does not reverse all existing heart or lung damage. Regular monitoring remains important.

Long-Acting Treatment

Tadalafil has a relatively long duration of action. For PAH, Adcirca is usually taken once daily rather than only when symptoms occur.

It must be taken regularly to maintain its effect on the blood vessels. It should not be used only before physical activity or when shortness of breath develops.

Do not skip doses or stop treatment without speaking with a healthcare provider.

Difference Between Adcirca and Erectile Dysfunction Treatment

Tadalafil is also used under other brand names to treat erectile dysfunction or urinary symptoms caused by an enlarged prostate.

Adcirca is specifically prescribed for pulmonary arterial hypertension. The dose and treatment instructions may be different from those used for erectile dysfunction.

Do not combine Adcirca with another tadalafil product or another PDE5 inhibitor unless a healthcare provider specifically directs you to do so.

Individualised Treatment

A healthcare provider will determine whether Adcirca is appropriate based on factors such as:

  • The cause and severity of PAH
  • Heart and lung function
  • Blood pressure
  • Kidney and liver function
  • Other medical conditions
  • Other medications
  • Response to previous PAH treatments
  • Risk of side effects

Adcirca may be used alone or together with other medications for pulmonary arterial hypertension.

Monitoring During Treatment

A healthcare provider may monitor:

  • Breathing symptoms
  • Exercise capacity
  • Blood pressure
  • Heart function
  • Oxygen levels
  • Kidney and liver function
  • Swelling and fluid retention
  • Treatment-related side effects

Tests may include walking assessments, blood tests, heart imaging, or other evaluations of pulmonary pressure and heart function.

Role in Long-Term Care

Adcirca helps manage PAH but does not cure the condition. Many people require long-term treatment and regular follow-up with a healthcare provider who specialises in heart or lung disease.

Treatment may also include other PAH medications, oxygen therapy, diuretics, supervised exercise, and measures to manage swelling or reduce strain on the heart.

Important Treatment Considerations

Adcirca can lower blood pressure and may cause headache, flushing, indigestion, muscle pain, back pain, or dizziness.

It must not be taken with nitrate medications because the combination can cause a dangerous drop in blood pressure.

Seek immediate medical care if you develop severe chest pain, fainting, sudden vision or hearing changes, severe shortness of breath, or an erection lasting longer than four hours.

Continue taking Adcirca exactly as prescribed and contact your healthcare provider if symptoms become worse or the medication does not appear to be helping.

Take Adcirca exactly as prescribed by your healthcare provider. It is taken by mouth once daily and may be taken with or without food.

Take the medication at approximately the same time every day. This helps maintain a consistent amount of tadalafil in your body.

Swallow the tablets with water. Do not change your dose or stop taking Adcirca without speaking with your healthcare provider. Stopping treatment may cause your pulmonary arterial hypertension symptoms to worsen.

Recommended Adult Dose

The usual adult dose for pulmonary arterial hypertension is 40 mg once daily.

This is commonly taken as two 20 mg tablets at the same time. Take both tablets together as one complete daily dose.

Do not divide the 40 mg dose into separate doses during the day.

Kidney Impairment

Kidney function can affect how quickly tadalafil is removed from the body.

For people with mild or moderate kidney impairment, a healthcare provider may start treatment at 20 mg once daily. The dose may later be increased to 40 mg once daily based on how well the medication is tolerated.

Adcirca is generally not recommended for people with severe kidney impairment, including those with a creatinine clearance below 30 mL/min or those receiving dialysis.

Individualised Treatment

The correct dose may depend on:

  • Kidney function
  • Liver function
  • Blood pressure
  • Other medical conditions
  • Other medications
  • Response to treatment
  • Treatment-related side effects

Do not take another tadalafil product or another phosphodiesterase type 5 inhibitor unless your healthcare provider specifically directs you to do so.

Missed Dose

Take a missed dose as soon as you remember. However, skip it if it is almost time for your next scheduled dose.

Continue with your regular schedule. Do not take two doses at the same time or take extra tablets to replace a missed dose.

Accidental Overdose

Taking more Adcirca than prescribed may cause severe headache, dizziness, fainting, low blood pressure, vision changes, or a prolonged erection.

Contact a healthcare provider, poison control centre, or emergency department immediately if you take too much Adcirca. Do not wait for symptoms to appear.

Common Side Effects of Adcirca (Tadalafil):

  • Back pain
  • Dizziness
  • Flushing
  • Flushing (warmth, redness, or tingly feeling)
  • Headache
  • Lightheadedness
  • Muscle pain
  • Nausea
  • Pain in your arms or legs
  • Runny or stuffy nose
  • Stomach upset
  • Stuffy nose
  • Upset stomach

Serious Side Effects of Adcirca (Tadalafil):

  • An erection that is painful or lasts longer than 4 hours
  • Chest pain or pressure
  • Difficulty breathing
  • Hives
  • Non-arteritic anterior ischemic optic neuropathy (NAION), which is a sudden decrease in vision
  • Pain spreading to your jaw or shoulder
  • Priapism or prolonged erection lasting for 4 hours
  • Ringing in the ears
  • Sudden hearing loss
  • Sudden vision loss
  • Sweating
  • Swelling of your face, lips, tongue, or throat
  • Trouble breathing
  • Vision changes

Adcirca (Tadalafil) is available in the following forms and strength:

Adcirca: Tablet

  • 20mg

Tadalafil: Tablet

  • 20mg

Pregnancy and Breastfeeding

Tell your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding.

There is limited information about the use of Adcirca during pregnancy and breastfeeding. Your healthcare provider will consider the benefits of controlling pulmonary arterial hypertension and the possible risks before recommending treatment.

Do not start or stop Adcirca without medical guidance.

Allergic Reactions

Adcirca may cause an allergic reaction in some people.

Stop taking the medication and seek immediate medical care if you develop:

  • Hives or a severe rash
  • Intense itching
  • Swelling of the face, lips, tongue, or throat
  • Difficulty breathing or swallowing
  • Severe dizziness or fainting

Prolonged Erection

Tadalafil may rarely cause priapism, which is a painful or prolonged erection lasting more than four hours. Without prompt treatment, priapism can permanently damage the penis.

The risk may be higher in people with certain conditions, including:

  • Sickle cell disease
  • Multiple myeloma
  • Leukaemia
  • Conditions that affect the shape of the penis

Seek emergency medical care if an erection lasts longer than four hours.

Kidney and Liver Problems

Tell your healthcare provider if you have kidney or liver disease.

These conditions can affect how quickly tadalafil is removed from the body. You may require a lower starting dose, closer monitoring, or a different treatment.

Adcirca is generally not recommended for people with severe kidney or liver impairment.

Nitrates and Dangerous Blood Pressure Drops

Do not take Adcirca with nitrate medications. This combination can cause a sudden and dangerous drop in blood pressure.

Nitrates may be used to treat chest pain and include medications such as nitroglycerin and isosorbide.

Tell emergency healthcare professionals when you last took Adcirca if you require treatment for chest pain.

Recreational Poppers

Do not combine Adcirca with recreational drugs called “poppers,” including amyl nitrite or butyl nitrite.

These substances act similarly to nitrates and can cause dangerously low blood pressure when combined with tadalafil.

Alpha-Blockers and Blood Pressure Medications

Adcirca may interact with alpha-blockers and other medications that lower blood pressure. Combining these medicines may increase dizziness, fainting, or dangerously low blood pressure.

Tell your healthcare provider about all prescription medications, nonprescription products, vitamins, and supplements you use.

Sudden Vision Changes

Rarely, tadalafil has been associated with a sudden decrease or loss of vision in one or both eyes.

Stop taking Adcirca and seek immediate medical attention if you develop sudden blurred vision, reduced vision, or vision loss.

Tell your healthcare provider if you have previously experienced serious vision loss or have risk factors for eye circulation problems.

Sudden Hearing Changes

Adcirca may rarely cause a sudden decrease or loss of hearing. This may occur with ringing in the ears or dizziness.

Stop taking the medication and seek prompt medical attention if you develop sudden hearing loss or a major change in hearing.

Heart and Circulation Conditions

Tell your healthcare provider if you have heart disease, very low blood pressure, an irregular heartbeat, chest pain, or a history of heart attack or stroke.

Adcirca is used to treat a serious heart and lung condition, so having cardiovascular disease does not automatically mean that the medication cannot be used. However, your healthcare provider must assess whether it is safe based on your blood pressure, heart function, symptoms, and other treatments.

Seek immediate medical care for severe chest pain, fainting, sudden weakness, difficulty speaking, or worsening shortness of breath.

Can Adcirca Be Taken With Other Medications?

Adcirca can interact with certain medications. Some combinations may cause dangerously low blood pressure or increase the risk of other serious side effects. Do not take Adcirca with nitrate medications, such as nitroglycerin or isosorbide. It should also not be combined with recreational “poppers” containing amyl nitrite or butyl nitrite. Use caution with alpha-blockers, blood pressure medications, certain antifungal medicines, some antibiotics, HIV medications, and other treatments for pulmonary arterial hypertension. Tell your healthcare provider about all prescription medications, nonprescription products, vitamins, herbal products, and supplements you use. Do not start or stop another medication without medical advice.

Is Adcirca Available Over the Counter?

No. Adcirca is only available with a prescription. A healthcare provider must assess your condition, medical history, and current medications before prescribing it. Regular follow-up may also be needed to check how well the treatment is working.

How Long Does Adcirca Take to Work?

Adcirca begins affecting the blood vessels after you take it, but improvements in breathing or exercise capacity may develop gradually. It may take several weeks of regular treatment to notice the full benefit. Continue taking Adcirca every day as prescribed, even if you do not notice an immediate change. Attend all follow-up appointments so your healthcare provider can assess your symptoms, exercise capacity, blood pressure, and response to treatment.

How Should Adcirca Be Stored?

Store Adcirca at room temperature in a dry place away from excessive heat, moisture, and direct light. Keep the tablets in their original container and out of the reach of children and pets. Do not store the medication in a bathroom or another humid area. Do not use tablets that are damaged, expired, or stored incorrectly.

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Additional Information Book
Generic name:

Tadalafil

Formulation:

Tablet

Strength(s):

20mg

Quantities Available:

56, 60, 112

Why customers love Online Pharmacies Canada

Our online Canadian Pharmacy is known for high standards of quality, safety, and efficiency when it comes to medications.

Our pharmacy offers lower prices on prescription drugs compared to traditional pharmacies.

How to Order

How much Adcirca can I order at once from a Canadian pharmacy?

When ordering Adcirca (tadalafil) from a Canadian pharmacy, you can typically purchase up to a 90-day supply at one time, which is common for prescription medications to ensure adequate management of chronic conditions without frequent refills.

Here’s what you need to know:

Dosage and Quantity: Adcirca is commonly prescribed in tablets of 20 mg strength for the treatment of PAH. The usual dosage is 40 mg (two tablets) taken once daily. For a 90-day supply, this means you would order 180 tablets (90 days x 2 tablets per day).

Do you sell tadalafil?

Yes, we sell tadalafil at our pharmacy, and you can enjoy low prices. However, to purchase tadalafil, you will need a valid prescription from your healthcare provider. We require this to dispense the medication safely and appropriately. You can provide your prescription by mailing, faxing, or uploading it through your online account.

Do you offer shipping of Adcirca (tadalafil) to the United States?

Yes, we ship Adcirca (tadalafil) to both the United States and Puerto Rico.

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Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Adcirca (Tadalafil). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Adcirca (Tadalafil).