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Rexulti contains the active ingredient brexpiprazole. It is a prescription medication that belongs to a group of medicines called atypical antipsychotics.
Rexulti is used to treat major depressive disorder, schizophrenia, and agitation associated with dementia caused by Alzheimer’s disease. The approved use depends on the patient’s age and condition.
Rexulti may be prescribed together with an antidepressant to treat major depressive disorder in adults when antidepressant treatment alone does not provide enough improvement.
Major depressive disorder can cause persistent sadness, loss of interest or pleasure, low energy, difficulty concentrating, sleep changes, and other symptoms that interfere with daily life.
Rexulti is not normally used by itself for depression. It is added to an existing antidepressant to help improve the response to treatment.
Rexulti is also used to treat schizophrenia in adults and adolescents aged 13 years and older. Schizophrenia can affect how a person thinks, feels, communicates, and understands reality.
Symptoms may include hallucinations, delusions, disorganized speech or thinking, reduced motivation, social withdrawal, and difficulty expressing emotions.
Rexulti may help reduce these symptoms and improve thinking, behaviour, and daily functioning. It helps manage schizophrenia but does not cure the condition.
Rexulti may be used to treat agitation associated with dementia caused by Alzheimer’s disease. Agitation may include restlessness, verbal aggression, physical aggression, repeated movements, or emotional distress.
Rexulti is taken regularly for this condition. It should not be used only when agitation suddenly occurs or as an “as-needed” medication.
Rexulti is not approved for dementia-related psychosis when agitation associated with Alzheimer’s dementia is not present.
Rexulti affects the activity of dopamine and serotonin, which are natural chemical messengers in the brain.
It acts as a partial agonist at certain dopamine and serotonin receptors. This means it can increase or reduce receptor activity depending on how much chemical signalling is already occurring.
Rexulti also blocks certain serotonin and adrenaline-related receptors. Together, these effects may help regulate mood, thinking, perception, behaviour, and agitation.
The exact way Rexulti improves each condition is not fully understood, and the response can differ from one person to another.
Rexulti does not usually provide immediate results. Some symptoms may begin to improve within the first few weeks, while the full benefit may take longer.
Take Rexulti every day exactly as prescribed, even if you do not notice an immediate improvement. Do not increase the dose or suddenly stop taking it without speaking with your healthcare provider.
Regular follow-up appointments are important so your healthcare provider can monitor how well the medication is working and check for side effects.
Rexulti is available as a tablet that is taken by mouth once daily. You may take it with or without food.
Take Rexulti at approximately the same time each day and follow your healthcare provider’s instructions carefully. Do not increase, reduce, or stop the medication without medical guidance.
Your dosage will depend on the condition being treated, your response to the medication, any side effects you experience, and other medicines you take. Your healthcare provider will usually begin with a low dose and increase it gradually to help reduce the risk of side effects.
Before starting treatment, tell your healthcare provider and pharmacist about all prescription medications, over-the-counter products, vitamins, and herbal supplements you use. Certain medicines can affect the amount of Rexulti in your body and may require a dosage adjustment.
When Rexulti is added to an antidepressant for major depressive disorder, the usual starting dose is 0.5 mg or 1 mg once daily.
Your healthcare provider may gradually increase the dose based on how well the medication works and how well you tolerate it. Dosage increases are generally made at weekly intervals.
The recommended target dose is 2 mg once daily. The maximum recommended dose for major depressive disorder is 3 mg once daily.
Rexulti is used together with an antidepressant for this condition and is not normally used by itself.
The usual starting dose for adults with schizophrenia is 1 mg once daily on Days 1 through 4.
The dose is generally increased to 2 mg once daily on Days 5 through 7. Beginning on Day 8, it may be increased to 4 mg once daily if additional symptom control is needed and the medication is well tolerated.
The recommended dose range is 2 mg to 4 mg once daily. The maximum recommended dose is 4 mg per day.
For adolescents aged 13 to 17 years, the usual starting dose is 0.5 mg once daily on Days 1 through 4.
The dose is typically increased to 1 mg once daily on Days 5 through 7 and then to 2 mg once daily on Day 8. Further increases may be made in 1 mg amounts at weekly intervals.
The recommended dose range is 2 mg to 4 mg once daily, with a maximum dose of 4 mg per day.
The usual starting dose is 0.5 mg once daily for the first seven days.
The dose is then generally increased to 1 mg once daily for Days 8 through 14 and to 2 mg once daily beginning on Day 15.
The recommended target dose is 2 mg once daily. After taking 2 mg for at least 14 days, the dose may be increased to a maximum of 3 mg once daily if needed and tolerated.
Rexulti should be taken regularly for this condition. It is not intended to be used only when agitation suddenly occurs.
Not everyone will need the highest recommended dose. Your healthcare provider will aim to find the lowest dose that provides adequate symptom control with manageable side effects.
Certain liver or kidney conditions may require a lower maximum dose. Dosage changes may also be needed when Rexulti is taken with medications that affect how it is processed by the body.
If you miss a dose, take it when you remember unless it is nearly time for your next dose. Skip the missed dose if your next dose is approaching. Do not take two doses at the same time.
Take Rexulti every day as prescribed, even if you do not notice an immediate improvement. Contact your healthcare provider before making any changes to your treatment.
Rexulti (Brexpiprazole) is available in the following forms and strength:
Tell your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding before taking Rexulti.
There is not enough information to clearly determine the risks of using Rexulti during pregnancy. Taking an antipsychotic during the third trimester may cause temporary symptoms in a newborn, including unusual muscle stiffness or weakness, shaking, sleepiness, breathing problems, or difficulty feeding.
Rexulti should be used during pregnancy only when your healthcare provider determines that the expected benefits outweigh the possible risks.
It is not known whether brexpiprazole passes into human breast milk. Your healthcare provider will help you decide whether to breastfeed or use Rexulti based on the medication’s importance to your treatment.
Rexulti can interact with medications that affect how brexpiprazole is processed by the body. Before starting treatment, tell your healthcare provider and pharmacist about every prescription medication, over-the-counter product, vitamin, and herbal supplement you take.
Fluoxetine and paroxetine may increase the amount of brexpiprazole in your body by slowing its breakdown. Certain antifungal medications and antibiotics may have a similar effect. This can increase the risk of side effects and may require a lower Rexulti dose.
Other medications, including strong enzyme-inducing drugs, may reduce the amount of Rexulti in the body and make it less effective. Do not start, stop, or change another medication without first consulting your healthcare provider.
Rexulti can cause side effects, although not everyone experiences them. Common effects may include weight gain, restlessness or an inability to remain still, sleepiness, dizziness, headache, and changes in appetite.
More serious risks can include uncontrolled body movements, high blood sugar, changes in cholesterol or triglyceride levels, low blood pressure, seizures, difficulty regulating body temperature, compulsive behaviours, and a rare but potentially life-threatening reaction called neuroleptic malignant syndrome.
Regular follow-up appointments may include checks of your weight, blood sugar, cholesterol levels, blood pressure, and movement-related symptoms.
The safety and effectiveness of Rexulti depend on the child’s age and the condition being treated.
Rexulti is approved to treat schizophrenia in adolescents aged 13 years and older. Its safety and effectiveness have not been established for schizophrenia in children younger than 13.
Rexulti has not been established as safe and effective for major depressive disorder in children or adolescents. Its use for agitation associated with Alzheimer’s dementia applies to adults, not children.
Antipsychotic medications, including Rexulti, can increase the risk of death in older adults with dementia-related psychosis.
Rexulti is approved for agitation associated with dementia caused by Alzheimer’s disease. However, it is not approved for other forms of dementia-related psychosis when Alzheimer’s-related agitation is not present.
Rexulti should not be used only when agitation suddenly occurs or on an “as-needed” basis. The healthcare provider should regularly evaluate whether treatment remains necessary and whether the benefits continue to outweigh the risks.
A boxed warning is the FDA’s strongest safety warning. It does not mean that everyone taking Rexulti will experience a serious reaction. It means that healthcare providers and patients must carefully consider specific risks and monitor treatment closely.
Rexulti carries a boxed warning about the increased risk of death in older adults with dementia-related psychosis. It also carries a warning about suicidal thoughts and behaviours associated with antidepressant treatment in children, adolescents, and young adults. This is particularly important when Rexulti is used with an antidepressant for major depressive disorder.
Patients, families, and caregivers should watch for new or worsening depression, suicidal thoughts, unusual mood changes, agitation, or changes in behaviour, especially when treatment begins or the dose is changed. Contact a healthcare provider promptly if these symptoms appear, and seek emergency assistance if there is an immediate risk of self-harm.
Rexulti has boxed warnings, which are the FDA’s strongest safety warnings. Antipsychotic medications, including Rexulti, can increase the risk of death in older adults with dementia-related psychosis. Although Rexulti is approved to treat agitation associated with dementia due to Alzheimer’s disease, it is not approved for other types of dementia-related psychosis and should not be used as an “as-needed” treatment for sudden agitation. Rexulti also carries a boxed warning about suicidal thoughts and behaviours associated with antidepressant treatment in children, adolescents, and young adults. This is particularly important when Rexulti is used with an antidepressant to treat major depressive disorder. Patients, family members, and caregivers should watch for new or worsening depression, suicidal thoughts, unusual behaviour, severe agitation, or sudden mood changes, especially when treatment begins or the dose changes. Seek emergency help if there is an immediate risk of self-harm.
Patient-support and savings options may be available, but eligibility depends on your location, insurance coverage, and other program requirements. In the United States, eligible patients with commercial insurance may qualify for the Rexulti Savings Card. Patient Services can also provide information about coverage and available assistance. Program details may change, so check the current official Rexulti information or ask your pharmacist or healthcare provider for assistance. The name “Patient Enrollment Line” may not refer to the current official program in every location. Patients in Canada or another country should ask their healthcare provider, pharmacist, insurer, or the local manufacturer’s patient-support service about available options.
Rexulti is taken by mouth once daily. It may be taken with or without food. Take it at approximately the same time every day and follow the dosing schedule provided by your healthcare provider. Do not take more than prescribed, skip doses regularly, or stop treatment suddenly without medical advice. Your healthcare provider may start you on a low dose and gradually increase it. The appropriate dose depends on the condition being treated, your response, possible side effects, and other medications you take.
The time required to notice improvement varies from person to person and depends on the condition being treated. Some symptoms may begin to improve during the first few weeks. However, it may take several weeks or longer to experience the medication’s full benefit, particularly because the dose is often increased gradually. Continue taking Rexulti as prescribed even if you do not notice immediate improvement. Contact your healthcare provider if your symptoms become worse, you experience concerning changes in behaviour, or the medication does not appear to be helping.
Store Rexulti tablets at controlled room temperature, generally between 20°C and 25°C. Brief exposure to temperatures between 15°C and 30°C is usually permitted. Keep the tablets in their original container, protected from excessive heat and moisture. Do not store them in a damp bathroom or near a sink. Keep Rexulti out of the sight and reach of children and pets. Do not use tablets that are damaged or past their expiry date. Ask a pharmacist how to safely dispose of medication that is no longer needed.
| Generic name: | Brexpiprazole |
|---|---|
| Formulation: | Tablet |
| Strength(s): | 0.5mg, 0.25mg, 1mg, 2mg, 3mg, 4mg |
| Quantities Available: | 30, 90, 100 |
Our online Canadian Pharmacy is known for high standards of quality, safety, and efficiency when it comes to medications.
Our pharmacy offers lower prices on prescription drugs compared to traditional pharmacies.
When ordering Rexulti (brexpiprazole) from a Canadian pharmacy, you can typically purchase up to a 90-day supply at one time, which is common for prescription medications to ensure adequate management of chronic conditions without frequent refills.
Here’s what you need to know:
Dosage and Quantity: Rexulti is commonly prescribed in dosages of 0.5 mg, 0.25 mg, 1 mg, 2 mg, 3 mg, and 4 mg, taken once daily. For a 90-day supply, you would order 90 tablets (90 days x 1 tablet per day).
No, our website does not sell brexpiprazole directly. However, you can still enjoy low prices on Rexulti, which contains brexpiprazole as an active ingredient. To purchase Rexulti, you will need a valid prescription from your healthcare provider. We require this to dispense the medication. You can conveniently submit your prescription by mail, fax, or upload it through your online account to facilitate the ordering process.
Yes, we ship Rexulti (brexpiprazole) to both the United States and Puerto Rico.
Watch how Online Pharmacies Canada is helping customers save money on their medications.
Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Rexulti (Brexpiprazole). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Rexulti (Brexpiprazole).
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