Pennsaid (Diclofenac sodium)

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Pennsaid Brand
Dosage Quantity & Price
Diclofenac sodium (Generic alternate to Pennsaid) Generic
Dosage Quantity & Price
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Table of contents:

PENNSAID is a nonsteroidal anti-inflammatory drug (NSAID) used to treat the pain of osteoarthritis (OA) of the knee(s) in adults. It contains an active ingredient called Diclofenac sodium. Diclofenac works by reducing the production of substances in the body that cause pain and inflammation.

Diclofenac is applied to the skin and delivers the active ingredient directly to the site of pain. PENNSAID is designed to provide relief from OA knee pain and reduce stiffness and physical limitations caused by the condition. However, like other NSAIDs, PENNSAID is associated with an increased risk of serious gastrointestinal adverse events, including bleeding and ulcers.

Uses and Dosage

Pennsaid comes in the form of a solution to be applied to the affected joint(s) twice a day, in the morning and evening. It should be spread evenly over the entire joint, and the hands should be washed immediately after applying. Do not shower, bathe, or swim for at least 30 minutes after applying Pennsaid.

The recommended dose of Pennsaid solution depends on the condition being treated. For the relief of the signs and symptoms of osteoarthritis of the knee(s), the recommended dose is 40 drops per knee, four times per day. This amounts to a total daily dose of 160 drops, or approximately 8 mL.

Side Effects

Common Side Effects of Pennsaid (Diclofenac sodium):

  • Bad breath
  • Bruising
  • Constipation
  • Diarrhea
  • Dizziness
  • Drowsiness
  • Gas
  • Indigestion
  • Nausea
  • Numbness and tingling
  • Rash (non-application site)
  • Skin irritation
  • Sore throat
  • Stomach pain
  • Stuffy nose
  • Upset stomach
  • Urinary tract infection

Signs of an Allergic Reaction to Pennsaid:

  • Sneezing
  • Runny or stuffy nose
  • Wheezing or trouble breathing
  • Hives
  • Swelling of your face, lips, tongue, or throat

Form and Strength

Pennsaid (Diclofenac sodium) is available in the following forms and strengths:

Pennsaid: Solution

  • 1.50%

Diclofenac sodium: Solution

  • 1.50%


  • Taking Pennsaid for a prolonged duration or in high doses, as well as having a pre-existing heart condition, can heighten the likelihood of experiencing a lethal heart attack or stroke.
  • While using Pennsaid, particularly among elderly patients, there is a possibility of experiencing stomach or intestinal bleeding without warning, which can be lethal.
  • Avoid using Pennsaid either before or after heart bypass surgery (coronary artery bypass graft or CABG) due to the potential risks associated with the medication.
  • Pennsaid should not be used by individuals who are allergic to diclofenac (known by various brand names such as Voltaren, Cataflam, and Flector), as using the medication in such cases can cause adverse reactions.
  • Do not use Pennsaid during pregnancy unless a doctor specifically advises its use. Using an NSAID, such as Pennsaid, during the last 20 weeks of pregnancy can increase the likelihood of developing serious heart or kidney problems in the unborn baby and lead to complications with the pregnancy.

Frequently Asked Questions (FAQ)

Can Pennsaid be used by everyone?

Pennsaid may not be safe for everyone, especially those with certain medical conditions or who are taking certain medications. Talk to your healthcare provider before using Pennsaid to make sure it is safe for you.

Is Pennsaid safe to use with other medications?

Discuss with your doctor or pharmacist any other medications, including over-the-counter medications and supplements that you are taking before using Pennsaid to ensure that there are no potential interactions.

How long does it take for Pennsaid to work?

The effects of Pennsaid may be felt within a few hours of application, but it may take several days of regular use to see the full benefits.

Can Pennsaid be used to treat conditions other than osteoarthritis?

Pennsaid is only approved by the FDA for the treatment of osteoarthritis, but it is sometimes used off-label to treat other types of pain and inflammation.

Does Pennsaid have any drug interactions?

Pennsaid may interact with other drugs, such as blood thinners or other NSAIDs. Discuss any medication changes with your doctor or pharmacist before starting or stopping any medications.


It's important to purchase Pennsaid from verified Canadian pharmacy.

Additional information

Generic name:

Diclofenac sodium





Quantities Available:

60mL, 180mL