Indications
Exjade is a medication used to treat chronic iron overload in patients who have received multiple blood transfusions. It contains the active substance deferasirox. Deferasirox belongs to a class of drugs known as iron-chelating agents.
Deferasirox works by binding to iron and removing it from the bloodstream and reduce liver iron concentration and serum ferritin levels in some patients. It helps in reducing the concentration of iron in the liver and serum ferritin levels in some patients who have received multiple blood transfusions.
Use and Dosage
Exjade is available in tablet and suspension form and should be taken once daily on an empty stomach, preferably 30 minutes before food. The tablet should not be chewed, or it must be swallowed whole. The tablets should be used in water, orange juice, or apple juice until the tablets have completely broken apart and are well mixed into the liquid. Patients should drink all the mixture right away, using about 1/2 cup (3.5 ounces/100 milliliters) of liquid for doses of less than 1 gram and about 1 cup (7 ounces/200 milliliters) for doses more than 1 gram.
Patients should take Exjade by mouth on an empty stomach at least 30 minutes before food, as directed by their healthcare provider, usually once daily. Patients should avoid taking this medication with antacids that contain aluminum, as this may affect how deferasirox works. Patients should always follow their healthcare provider's instructions when taking this medication.
Side Effects
Common Side Effects of Exjade (Deferasirox):
- Abdominal discomfort
- Diarrhea
- Dizziness
- Fatigue
- Headache
- Insomnia
- Loss of appetite
- Nausea
- Vomiting
Serious Side Effects of Exjade (Deferasirox):
- Bleeding
- Easy bruising
- Fever, chills, or persistent sore throat (signs of infection)
- Hearing loss
- Symptoms of kidney problems (change in urine output, frothy urine)
- Symptoms of liver damage (abdominal pain, persistent vomiting, yellowish skin, dark urine)
- Vision changes
Forms and Strength
Exjade (Deferasirox) available in the following forms and strength:
Exjade: Dispersible Tablet
- 125 mg
- 250 mg
- 500 mg
Deferasirox: Dispersible Tablet
- 125 mg
- 500 mg
Cautions
- Exjade can cause renal failure, particularly in patients with pre-existing renal impairment or those who are taking nephrotoxic drugs. Close monitoring of renal function is necessary.
- Exjade can cause nausea, vomiting, and diarrhea. In some cases, these side effects can be severe and require dose reduction or discontinuation of therapy.
- Exjade can cause abnormal liver function tests, hepatitis, and jaundice. These effects are generally reversible upon discontinuation of therapy.
- Exjade can cause skin rashes, which may require treatment with antihistamines or corticosteroids.
- Exjade can cause auditory and ocular disturbances, including high-frequency hearing loss, decreased visual acuity, and cataracts. Regular monitoring of these functions is necessary.
- Exjade can lower the body's immune response and increase the risk of infections. Patients taking the drug should avoid close contact with people with communicable infections.
- Exjade may interact with other drugs, including antacids, antifungals, and antibiotics, leading to adverse effects.
- Exjade can cause bleeding, such as bruising and petechiae. Patients who develop these side effects should be monitored closely and assessed for potential bleeding disorders.
- Exjade can cause allergic reactions, including rash, pruritus, urticaria, and anaphylaxis. These effects require immediate medical attention.
- Exjade is not recommended for use during pregnancy or breastfeeding due to the potential risk to the fetus or infant.
Frequently Asked Questions
Can Exjade cause kidney damage?
Yes, Exjade can cause kidney damage, particularly in patients with pre-existing renal impairment or those taking nephrotoxic drugs. Close monitoring of renal function is necessary.
What should I do if I overdose on Exjade?
If you overdose on Exjade, seek immediate medical attention. Symptoms of overdose may include gastrointestinal side effects, renal failure, and liver function abnormalities.
How long does it take for Exjade to work?
The effectiveness of Exjade varies depending on factors such as the patient's iron overload level, age, and disease type. It may take several months to see significant reductions in iron levels.
Can Exjade be taken with food?
Yes, Exjade can be taken with or without food. However, it should be taken at the same time each day to maintain consistent blood levels.
Can Exjade be used in children?
Yes, Exjade is approved for use in children aged 2 years and above who have received frequent blood transfusions due to conditions such as thalassemia and sickle cell disease.
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