Indications
DDAVP Melt is an orally disintegrating tablet used to treat conditions that involve excessive urination or thirst. It is used to treat bedwetting and central cranial diabetes insipidus. DDAVP Melt can be used to manage conditions such as nocturnal enuresis (bedwetting), diabetes insipidus, and primary cranial polydipsia.
DDAVP Melt contains the active ingredient desmopressin, which is a synthetic analogue of ADH. It works by mimicking the action of antidiuretic hormone (ADH), also known as vasopressin, which is produced naturally by the pituitary gland in the brain. ADH helps to regulate the body's water balance by instructing the kidneys to reduce the amount of urine produced. Desmopressin binds to the same receptors as ADH in the kidneys, reducing urine production and increasing urine concentration.
Use and Dosage
DDAVP melt comes in the form of Rapid Dissolve tablets, which are taken orally by mouth usually 2 to 3 times a day or as directed by your doctor. The tablet dissolves rapidly on the tongue and should be swallowed whole, do not chew, or break it.
The recommended dosage for DDAVP melt may vary depending on the individual patient and their response to treatment. The suitable starting dose in adults and children is 60 micrograms three times daily, administered sublingually (under the tongue). This dosage regimen should then be adjusted as needed based on the patient's response to treatment. It is worth noting that the recommended dose for women may be lower than for men due to differences in response to the medication.
Take the tablet exactly as prescribed by your doctor. If you are taking DDAVP melt for controlling excessive urination at night and you miss a dose, skip the missed dose, and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Side Effects
Common Side Effects of DDAVP MELT (Desmopressin):
- Diarrhea
- Flushing of the face (warmth, redness, tingly feeling)
- Headache
- Nausea
- Upset stomach or stomach pain
Serious Side Effects of DDAVP MELT (Desmopressin):
- Dizziness
- Loss of appetite
- Loss of consciousness
- Mental/mood changes (confusion, hallucinations, irritability)
- Muscle weakness/spasms/cramps
- Nausea
- Seizures
- Severe drowsiness
- Severe headache
- Slow/shallow breathing
- Unusual tiredness
- Vomiting
- Weight gain
Forms and Strength
DDAVP MELT (Desmopressin) is available in the following forms and strength:
DDAVP MELT: Tablet Rapid Dissolve
- 60 mg
- 120 mg
Cautions
- Risk of water intoxication and hyponatremia, especially in patients with conditions that predispose them to fluid and electrolyte imbalance.
- Risk of seizures in patients with a history of the condition.
- Potential for drug interactions with other medications that affect fluid and electrolyte balance, such as diuretics and nonsteroidal anti-inflammatory drugs (NSAIDs).
- Risk of decreased blood pressure and fainting in patients who have a history of cardiovascular disease.
- The medication should be used with caution in patients with kidney or liver problems.
- Patients should be advised not to take the medication if they have a medical condition that places them at high risk of thrombosis or clotting, such as thrombophilia or certain types of heart disease. Speak with a healthcare provider about any concerns or questions regarding the use of DDAVP Melt.
- Patients who experience a decrease in plasma sodium levels should be monitored closely and the dose of medication should be adjusted if necessary.
- DDAVP Melt should be used with caution in patients with fluid overload or heart failure.
- Patients should be advised not to consume excessive amounts of fluids while taking DDAVP Melt.
- The medication should be used with caution in pediatric patients and the elderly.
- Patients should be advised to discontinue the medication and seek medical attention if they experience symptoms such as severe headache, seizures, confusion, visual disturbances, or sudden weight gain as these may be signs of water intoxication or hyponatremia.
Frequently Asked Questions (FAQ)
How long does it take for DDAVP Melt to start working?
DDAVP Melt usually starts working within one hour of taking the medication.
How long should I take DDAVP Melt?
The length of treatment with DDAVP Melt depends on the condition being treated and the patient's response to the medication. Patients should consult with their healthcare provider regarding the appropriate duration of treatment.
Is DDAVP Melt addictive?
DDAVP Melt is not addictive.
Can DDAVP Melt be used to treat other conditions?
DDAVP Melt is primarily used to treat conditions that involve excessive urination or thirst, but it may be used off-label to treat other conditions at the discretion of the healthcare provider.
Resources
- https://www.rxlist.com/ddavp-drug.htm
- https://www.everydayhealth.com/drugs/desmopressin
- https://www.medbroadcast.com/drug/getdrug/ddavp
- https://medlineplus.gov/druginfo/meds/a608010.html
- https://www.northwestpharmacy.com/product/ddavp-melt
- https://www.webmd.com/drugs/2/drug-12145/ddavp-oral/details
- https://patient.info/medicine/desmopressin-ddavp-desmomelt-desmospray-desmotabs-octim
- https://www.ferring.ca/media/1068/ddavp-melt-product-monograph_en-17dec2015.pdf
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