Cloxapen (Cloxacillin)

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Cloxapen Brand

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Cloxacillin (Generic alternate to Cloxapen) Generic
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Cloxapen (generically known as Cloxacillin) is an antibiotic used to treat bacterial infections caused by susceptible organisms and a wide range of bacterial infections. It is commonly used to treat skin and soft tissue infections, respiratory tract infections, and bone and joint infections. It works by stopping the growth of bacteria or killing the bacteria altogether.

Cloxacillin is classified as a penicillinase-resistant penicillin. It works by inhibiting the growth and reproduction of bacteria. Specifically, it does this by interfering with the cell wall synthesis of the bacteria, which leads to the eventual destruction of the bacterial cell.

Cloxapen is effective against a wide range of Gram-positive bacteria, including staphylococci and streptococci. Note that Cloxapen is only effective against bacterial infections and not viral infections.

Use and Dosage

Cloxapen capsules should be taken orally as per the doctor's instructions. Take the capsules on an empty stomach, which could be 1 hour before or 2 hours after a meal for best absorption.

The dosage of Cloxapen is based on the patient's medical condition and response. In children, the dosage is based on age and weight. Taking the drug at the same time every day is recommended for optimal results. Complete the prescribed course of antibiotics even if symptoms disappear before the course is complete. Stopping the medication too soon could lead to recurrent infections and antibiotic resistance. If the situation persists or worsens, patients are advised to inform their healthcare provider.

Continue to take Cloxapen capsules until the full prescribed amount is finished, even if symptoms disappear after a few days. Stopping the medication too early may allow bacteria to continue to grow, which may result in a relapse of the infection.

Side Effects

Common Side Effects of Cloxapen (Cloxacillin):

Serious Side Effects of Cloxapen (Cloxacillin):

  • Abdominal or stomach cramps and pain (severe)
  • Abdominal tenderness
  • Convulsions (seizures)
  • Decreased amount of urine
  • Diarrhea (watery and severe), which may also be bloody
  • Fast or irregular breathing
  • Fever
  • Joint pain
  • Lightheadedness or fainting (sudden)
  • Mental depression
  • Nausea and vomiting
  • Pain at place of injection
  • Puffiness or swelling around the face
  • Red or scaly skin
  • Shortness of breath
  • Skin rash, hives, or itching
  • Sore throat and fever
  • Unusual bleeding or bruising
  • Yellow eyes or skin

Forms and Strength

Cloxapen (Cloxacillin) is available in the following forms and strength:

Cloxacillin: Capsule

  • 500 mg


  • Allergy: Anyone who has had an allergic reaction to penicillin antibiotics in the past should not take Cloxapen.
  • Interactions: Cloxapen can interact with other medications such as methotrexate, which is used to treat cancer and autoimmune disorders, and may increase the risk of side effects.
  • Pregnancy and breastfeeding: Pregnant or breastfeeding women should consult their doctor before taking Cloxapen, as it may harm the baby or pass into breast milk.
  • Liver and kidney diseases: Cloxapen may not be recommended for people with liver or kidney diseases, as it can worsen their symptoms.
  • Immune system disorders: Cloxapen may not be recommended for people with immune system disorders, as it may interfere with their ability to fight infections.
  • Gastrointestinal disorders: Cloxapen may cause gastrointestinal discomfort such as nausea, vomiting, and diarrhea.
  • Blood clotting disorders: Cloxapen may interfere with blood clotting and may not be recommended for people with bleeding disorders.
  • Seizures: There have been rare reports of seizures in people taking Cloxapen, particularly in those with a history of seizures.
  • Antibiotic resistance: Overuse or misuse of antibiotics can lead to antibiotic resistance, which means that the bacteria become resistant to the effects of the medication and treatment may become more difficult.
  • Follow-up care: Follow-up with a healthcare professional after finishing a course of Cloxapen to ensure that the infection has been properly treated and to monitor for any potential side effects or complications.

Frequently Asked Questions (FAQ)

How long does it take for Cloxapen to start working?

The amount of time it takes for Cloxapen to start working will depend on the type and severity of the infection being treated. In general, individuals may start to see improvements within a few days of starting treatment with Cloxapen.

Is it safe to drink alcohol while taking Cloxapen?

Do not drink alcohol while taking antibiotics as it can interfere with the effectiveness of the medication and may increase the risk of side effects. Speak with a healthcare professional to determine if alcohol use is safe while taking Cloxapen.

Can I stop taking Cloxapen once my symptoms start to improve?

No, finish the entire course of treatment with Cloxapen, even if symptoms start to improve. Stopping the medication early may lead to the development of antibiotic-resistant bacteria or a recurrence of the infection.

Does Cloxapen interact with hormonal contraceptives?

There are no known interactions between Cloxapen and hormonal contraceptives such as birth control pills. However, it is best to check with a healthcare professional to be sure.


It's important to purchase Cloxapen from verified Canadian pharmacy.

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