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Zestoretic contains two active ingredients: lisinopril and hydrochlorothiazide. It is a prescription medication used to treat high blood pressure (hypertension).
Zestoretic helps lower blood pressure when it stays higher than normal.
High blood pressure can put extra strain on the heart and blood vessels. Over time, this can increase the risk of serious health problems such as:
Lowering blood pressure helps reduce this strain and can lower the risk of these complications.
Zestoretic combines two different types of blood pressure medication.
Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor. It helps relax and widen blood vessels, making it easier for blood to flow.
Hydrochlorothiazide is a thiazide diuretic, sometimes called a water pill. It helps the kidneys remove extra sodium and water from the body through the urine.
The two ingredients work in different ways to lower blood pressure.
Lisinopril relaxes the blood vessels, while hydrochlorothiazide reduces excess fluid in the body.
Using them together may provide better blood pressure control than either medicine alone in some people.
Zestoretic helps control high blood pressure, but it does not cure it.
Continue taking it exactly as prescribed, even if you feel well, because high blood pressure often does not cause noticeable symptoms.
Zestoretic is taken by mouth, usually once daily.
You can take it with or without food.
Try to take it at about the same time each day so the medication works consistently.
Because Zestoretic contains hydrochlorothiazide, it may make you urinate more often.
Many people take it in the morning to reduce the chance of needing to urinate during the night.
If you take it later in the day, try to take it several hours before bedtime unless your healthcare provider tells you otherwise.
The exact dose depends on your current blood pressure treatment and how well your blood pressure is controlled.
People whose blood pressure is not adequately controlled with lisinopril or hydrochlorothiazide alone may be switched to combinations such as:
Your healthcare provider may adjust the dose based on your blood pressure response.
Your healthcare provider may gradually increase one or both ingredients if your blood pressure remains too high.
The hydrochlorothiazide portion is generally not increased until at least 2 to 3 weeks have passed.
Doses above 80 mg of lisinopril and 50 mg of hydrochlorothiazide per day should not be used.
Take Zestoretic every day as prescribed, even if you feel well.
High blood pressure often does not cause noticeable symptoms, so you may not feel any different even when the medication is working.
If you take medicines such as cholestyramine or colestipol to lower cholesterol, they may reduce the absorption of hydrochlorothiazide.
Your healthcare provider or pharmacist may recommend taking Zestoretic at a different time from these medications.
If you miss a dose of Zestoretic, take it when you remember unless it is almost time for your next scheduled dose.
If your next dose is approaching, skip the missed dose and continue with your regular schedule.
Do not take two doses at the same time to make up for a missed dose.
Do not increase, decrease, or stop Zestoretic without speaking with your healthcare provider.
Contact your healthcare provider if your blood pressure remains high, becomes higher, or you develop troublesome side effects.
Your dose or treatment plan may need to be adjusted.
Zestoretic (Lisinopril/HCTZ) is available in the following forms and strength:
Do not use Zestoretic during pregnancy.
Lisinopril can harm a developing fetus, especially during the second and third trimesters.
If you become pregnant while taking Zestoretic, contact your healthcare provider right away. The medication should usually be stopped as soon as pregnancy is detected.
Breastfeeding is generally not recommended while taking Zestoretic.
Tell your healthcare provider if you are breastfeeding or planning to breastfeed so another treatment can be considered.
Tell your healthcare provider if you have kidney disease.
Zestoretic can affect kidney function, especially if you are dehydrated or take other medications that affect the kidneys.
Your healthcare provider may monitor your kidney function with blood tests.
Zestoretic should be used carefully in people with liver disease.
Changes in fluid and electrolyte levels may be more serious in people with liver problems.
Rarely, ACE inhibitors such as lisinopril have also been linked to serious liver injury.
Hydrochlorothiazide helps remove extra fluid from the body.
Too much fluid loss can cause dehydration or a significant drop in blood pressure.
Symptoms may include:
The risk may be higher if you have vomiting, diarrhea, heavy sweating, or are not drinking enough fluids.
Zestoretic can change the levels of electrolytes in your blood.
Hydrochlorothiazide may cause low levels of:
Symptoms may include muscle cramps, weakness, tiredness, confusion, nausea, or an abnormal heartbeat.
Lisinopril can sometimes cause high potassium levels, so your healthcare provider may monitor your electrolytes regularly.
Hydrochlorothiazide may raise blood sugar levels.
If you have diabetes, monitor your blood glucose as directed and tell your healthcare provider if your readings change significantly.
Your diabetes medications may occasionally need to be adjusted.
Hydrochlorothiazide can reduce the amount of calcium removed in the urine and may increase blood calcium levels.
Tell your healthcare provider if you have hyperparathyroidism, high calcium levels, or another condition affecting calcium balance.
Do not take Zestoretic if you have had a serious allergic reaction to lisinopril or another ACE inhibitor.
ACE inhibitors can rarely cause angioedema, which is sudden swelling under the skin.
Seek emergency medical attention if you develop swelling of the face, lips, tongue, or throat, or have difficulty breathing or swallowing.
Hydrochlorothiazide is a sulfonamide-derived medication.
Tell your healthcare provider if you have had a serious reaction to sulfonamide medications in the past.
Zestoretic can increase lithium levels and raise the risk of lithium toxicity.
Symptoms may include tremor, confusion, severe nausea, vomiting, diarrhea, or poor coordination.
Lithium and Zestoretic generally require careful monitoring if they must be used together.
Nonsteroidal anti-inflammatory drugs, or NSAIDs, such as ibuprofen and naproxen may:
Check with your healthcare provider before regularly using NSAIDs while taking Zestoretic.
Tell your healthcare provider about all prescription medications, over-the-counter products, vitamins, supplements, and herbal products you use.
Zestoretic may interact with other blood pressure medications, diuretics, potassium supplements, potassium-containing salt substitutes, and other medicines that affect kidney function or electrolyte levels.
Your healthcare provider may regularly check:
These tests help make sure Zestoretic is lowering your blood pressure safely.
Seek medical attention if you develop severe dizziness, fainting, difficulty breathing, swelling of the face or throat, very little urine, severe weakness, confusion, or an abnormal heartbeat.
These symptoms may indicate a serious reaction, kidney problem, or electrolyte imbalance.
Zestoretic can be taken with or without food. Try to take it the same way each day so it becomes part of your regular routine. Continue taking Zestoretic for as long as your healthcare provider recommends, even if you feel well.
Zestoretic is usually taken once daily. Because it contains hydrochlorothiazide, it may make you urinate more often. Many people therefore take it in the morning. If you take it later in the day, try to take it at least 4 hours before bedtime to reduce the chance of waking up during the night to urinate.
Zestoretic may begin lowering your blood pressure within the first several hours after a dose. However, it can take 2 to 4 weeks to see the full blood pressure-lowering effect. Continue taking it as prescribed, and contact your healthcare provider if your blood pressure remains high or becomes worse.
| Generic name: | Lisinopril/HCTZ, Lisinopril/Hctz |
|---|---|
| Formulation: | Tablet |
| Strength(s): | 10/12.5mg, 20/12.5mg, 20/25mg |
| Quantities Available: | 84, 90, 100 |
Our online Canadian Pharmacy is known for high standards of quality, safety, and efficiency when it comes to medications.
Our pharmacy offers lower prices on prescription drugs compared to traditional pharmacies.
When ordering Zestoretic (lisinopril/HCTZ) from a Canadian pharmacy, you can typically purchase up to a 90-day supply at one time, which is common for prescription medications to ensure adequate management of chronic conditions without frequent refills.
Here’s what you need to know:
Dosage and Quantity: Zestoretic is commonly prescribed in dosages of 20 mg/12.5 mg or 20 mg/25 mg, taken once daily. For a 90-day supply, this means you would order 90 tablets (90 days x 1 tablet per day).
Yes, we sell lisinopril/HCTZ on our website. You can enjoy low prices when you order through us. To purchase lisinopril/HCTZ, you will need a valid prescription from your healthcare provider. We require this prescription to dispense the medication safely and appropriately. You have the option to submit your prescription by mailing it to us, faxing it, or uploading it through your online account.
Yes, we ship Zestoretic (lisinopril/HCTZ) to both the United States and Puerto Rico.
Watch how Online Pharmacies Canada is helping customers save money on their medications.
Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Zestoretic (Lisinopril/HCTZ). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Zestoretic (Lisinopril/HCTZ).
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